Results 41 to 50 of about 47,981 (309)
Thiazole Ring—A Biologically Active Scaffold
Molecules, 2021 Background: Thiazole is a good pharmacophore nucleus due to its various pharmaceutical applications. Its derivatives have a wide range of biological activities such as antioxidant, analgesic, and antimicrobial including antibacterial, antifungal ...
Anthi Petrou +2 more
doaj +1 more source
Could valerian have been the first anticonvulsant? [PDF]
, 2004 To assess the available evidence for the belief that valerian, highly recommended in the past for treating epilepsy, possessed real anticonvulsant effectiveness.Review of available literature.In 1592, Fabio Colonna, in his botanical classic Phytobasanos,
Eadie, Mervyn J., Mervyn J. Eadie
core +1 more source
Evaluation of anticonvulsant activity of amlodipine in albino rats [PDF]
, 2017 Background: The objective of the study was to evaluate the anticonvulsant activity of amlodipine in albino rats.Methods: Anticonvulsant activity of amlodipine was done in three graded doses (1 mg/kg, 2 mg/kg, 4 mg/kg), and combination group with low dose
M., Janardhan +5 more
core +2 more sources
Reduced Effect of Anticonvulsants on AMPA Receptor Palmitoylation-Deficient Mice
Frontiers in Pharmacology, 2021 AMPA receptors are responsible for fast excitatory synaptic transmission in the mammalian brain. Post-translational protein S-palmitoylation of AMPA receptor subunits GluA1-4 reversibly regulates synaptic AMPA receptor expression, resulting in long ...
Madoka Iizumi +4 more
doaj +1 more source
Bone Mineral Density in Patients Receiving Anticonvulsant Drugs [PDF]
, 2002 The study was carried out to determine possible effects of anticonvulsant drugs on bone mineral density. Twenty two patients with epilepsy who have been receiving anticonvulsant drugs and also 22 healthy controls were included in the study.
Kazım Şenel +4 more
core
Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina +11 more
wiley +1 more source
Frontiers in Pharmacology, 2014 Alpha (α)-asarone, a major effective component isolated from the Chinese medicinal herb Acorus tatarinowii, is clinically used as medication for treating epilepsy, cough, bronchitis, and asthma.
Ze-Jun eWang +3 more
doaj +1 more source
A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling +16 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Chimeric antigen receptor (CAR) T‐cell therapy has been investigated in neurological diseases, encompassing both central nervous system malignancies and autoimmune disorders, thereby extending its application beyond hematological cancers.
Omar Alqaisi +5 more
wiley +1 more source
Developmental Toxicity Study of DL-4-Hydroxy-4-Phenylhexanamide (DL-HEPB) in Rats
Life, 2023 Antiepileptic drugs affect embryonic development when administered during pregnancy, generating severe alterations, such as as cleft lip, spina bifida, heart abnormalities, or neuronal alterations.
José Melesio Cristóbal-Luna +5 more
doaj +1 more source