Results 41 to 50 of about 53,577 (300)

Ofatumumab Therapy and Long‐Term Seizure Outcomes of Patients With Relapsing Anti‐NMDA Receptor Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There is a lack of studies on seizure outcomes associated with ofatumumab therapy in patients for relapsing anti‐N‐methyl‐D‐aspartate (NMDA) receptor encephalitis. We aimed to evaluate long‐term seizure outcomes of ofatumumab therapy for relapsing anti‐NMDA receptor encephalitis.
Jian Wang, Mengjiao Li, Ping Kong
wiley   +1 more source

Anticonvulsants to treat idiopathic restless legs syndrome: systematic review Anticonvulsivantes para a síndrome das pernas inquietas idiopática: revisão sistemática

Arquivos de Neuro-Psiquiatria, 2008
BACKGROUND: Restless legs syndrome (RLS) is a sensory motor disorder characterized by a distressing urge to move the legs and sometimes also other parts of the body usually accompanied by a marked sense of discomfort or pain in the leg or other affected ...
Cristiane Fiquene Conti, Márcio Moysés de Oliveira, Juliana Spelta Valbuza, Lucila Bizari F. Prado, Luciane Bizari Coin de Carvalho, Gilmar Fernandes do Prado   +5 more
doaj   +1 more source

Pirfenidone regulates seizures through the HMGB1/TLR4 axis to improve cognitive functions and modulate oxidative stress and neurotransmitters in PTZ-induced kindling in mice

Frontiers in Pharmacology
BackgroundEpilepsy is a neurological disorder characterized by recurrent seizures due to abnormal electrical activity in the brain. Pirfenidone, an antifibrotic drug, has shown anti-inflammatory and antioxidant properties in various disease models ...
Mansi Dahalia, Sparsh Gupta, Haya Majid, Divya Vohora, Nidhi   +4 more
doaj   +1 more source

Synthesis, Modelling, and Anticonvulsant Studies of New Quinazolines Showing Three Highly Active Compounds with Low Toxicity and High Affinity to the GABA-A Receptor

Molecules, 2017
Some novel fluorinated quinazolines (5a–j) were designed and synthesized to be evaluated for their anticonvulsant activity and their neurotoxicity. Structures of all newly synthesized compounds were confirmed by their infrared (IR), mass spectrometry (MS)
Mohamed F. Zayed, Saleh K. Ihmaid, Hany E. A. Ahmed, Khaled El-Adl, Ahmed M. Asiri, Abdelsattar M. Omar   +5 more
doaj   +1 more source

Triazoline Anticonvulsant Drugs [PDF]

, 1985
Anticonvulsant compositions comprise as the active ingredient a compound . . .
Kadaba, Pankaja K.
core  

Sulforaphane is anticonvulsant and improves mitochondrial function

, 2015
The nuclear factor erythroid 2-related factor 2 pathway (Nrf2) has been previously identified to protect the brain against various impacts. Here, we investigated the effect of the Nrf2 activator sulforaphane in various seizure models and hippocampal ...
Carrasco-Pozo, Catalina, Borges, Karin, Kah, Ni Tan   +2 more
core   +1 more source

Co‐activation of Selective Nicotinic Acetylcholine Receptor Subtypes Is Required for Neuroprotection against Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT Beta‐amyloid peptide (Aβ)‐induced suppression of hippocampal GABAergic interneuron activity drives hyperexcitability, amyloid pathology, and cognitive impairment in Alzheimer's disease (AD), suggesting that enhancing hippocampal inhibition may be protective.
Rahmi Lee, Gayeon Kim, Ellison R. Black, Seonil Kim   +3 more
wiley   +1 more source

Anticonvulsant hypersensitivity syndrome treated with intravenous immunoglobulin

, 2010
Anticonvulsant hypersensitivity syndrome is a severe, potentially life-threatening, reaction to the aromatic anticonvulsant medications. Reported here is a case of anticonvulsant hypersensitivity syndrome secondary to phenobarbital in a 2-year-old boy ...
Dredge, David, MD
core   +1 more source

Anticonvulsant activity of Nigella sativa, Aegle marmelos and Benincasa hispida in Pentylenetetrazole induced seizure in Swiss albino mice

Asian Journal of Medical Sciences, 2016
Aims and Objectives: To test anticonvulsant properties of three medicinal plants with pentylenetetrazole induced seizure test in Swiss albino mice. Materials and Methods: Herbs selected for the work (leaves of Aegle marmelos, seed of Nigella sativa ...
Rejeesh Edavan Puthallath
doaj   +1 more source

Salvinorin A Does Not Affect Seizure Threshold in Mice

Molecules, 2020
The κ-opioid receptor has recently gained attention as a new molecular target in the treatment of many psychiatric and neurological disorders including epilepsy.
Katarzyna Socała, Urszula Doboszewska, Piotr Wlaź   +2 more
doaj   +1 more source