Results 61 to 70 of about 47,981 (309)

Plausible antioxidant biomechanics and anticonvulsant pharmacological activity of brain-targeted β-carotene nanoparticles [PDF]

, 2012
Mohammad Yusuf,1 Riaz A Khan,3 Maria Khan,2 Bahar Ahmed11Department of Pharmaceutical Chemistry, 2Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Hamdard University, New Delhi, India; 3Department of Chemistry, Manav Rachna ...
Khan RA, Khan M, Yusuf M, Ahmed B
core  

New fluorinated quinazolinone derivatives as anticonvulsant agents [PDF]

, 2014
ObjectivesThe aim of the present work was to synthesize some novel fluorinated quinazolinones and to evaluate them for anticonvulsant activity and neurotoxicity.MethodsEight compounds were synthesized.
Zayed, Mohamed F.
core   +1 more source

Lesion Site‐Targeted Microspheres Modulate Nav1.7‐Related Signaling for Osteoarthritis Treatment

Advanced Science, EarlyView.
Cartilage‐targeted carbamazepine‐loaded WYRGRL‐modified composite microspheres (CBZ/WCOM) anchor to exposed type II collagen in osteoarthritic lesions and release carbamazepine under acidic conditions. This bind‐then‐release platform modulates Nav1.7‐related sodium signaling, Na⁺/Ca²⁺ exchanger‐associated Ca2+ dynamics, and heat shock protein 70 ...
Cheng Chen, Jiaying Li, Jinjin Ma, Xiaonan Yuan, Yao Xiao, Yang Zhang, Yuan Chen, Hao Jiang, Hui He, Jie Hu, Qianglong Chen, Jinniu Zhang, Bin Li, Yun Zhou, Fengxuan Han, Yong Wang   +15 more
wiley   +1 more source

Evaluation of Clematis hedysarifolia DC. for potential anticonvulsant activity in Pentylenetetrazol and Strychnine induced convulsion in albino mice [PDF]

International Journal of Minor Fruits, Medicinal and Aromatic Plants
Juice of Clematis hedysarifolia DC, has been employed in the treatment of seizures and various neurological disorders. Research objective was to examine anticonvulsant effects of different solvent extracts of leaf and stem parts of Clematis hedysarifolia
Sonali Gawali
doaj   +1 more source

Comparison of Magnesium Sulphate Protocols by Weight-Adjusted Versus Two Grams Per Hour for Preventing Convulsion in Preeclampsia: A Randomised Controlled Trial [PDF]

Journal of Clinical and Diagnostic Research, 2019
Introduction: Magnesium Sulphate (MgSO4 ) is the most effective drug used for seizure prevention in preeclampsia; however, the dosage of MgSO4 is still in controversy.
Saowanee Tangmanowutthikul, Rawisara Champawong, Srisuda Songthamwat, Metha Songthamwat   +3 more
doaj   +1 more source

The original anticonvulsant meta-Cl-benzhydrylurea (m-CL-BHM) induces of the liver monooxygenase system and stimulates the neuroimmune response in behavioral disorders of alcoholic origin

European Psychiatry, 2022
Introduction The anticonvulsant m-Cl-BHM is promising for the pathogenetically directed thrapy does not cause negative effects. Objectives Investigation of the effect of m-Сl-BHM on “immunochemical homeostasis” in rats with experimental alcoholism ...
Т. Shushpanova, T. Novozheeva, E. Gutkevich, A. Pustovaya, N. Garganeeva, M. Belousov, A. Podyablonsky, E. Markova, E. Knyazeva, O. Shushpanova, N. Kolomiets, S. Safronov, R. Boev   +12 more
doaj   +1 more source

Anticonvulsant properties of amino-oxyacetic acid [PDF]

, 1961
Amino-oxyacetic acid (AOAA), a compound which inhibits γ-aminobutyric-α-ketoglutaric transaminase in vitro and causes accumulations of γ-aminobutyric acid (GABA) in vivo, has anticonvulsant activity against convulsions caused by thiosemicarbazide in ...
M. E. Greig, M. A. Cronin, J. P. Da Vanzo   +2 more
core   +1 more source

Fatty Acid Binding Protein 5 Mediates Astrocytic Pyroptosis and Neuroinflammation in Epilepsy via cGAS/STING Pathway

Advanced Science, EarlyView.
Astrocytic FABP5 promotes mitochondrial stress, cGAS‐STING pathway activation, pyroptosis, and neuroinflammation in epilepsy, contributing to seizure pathology. Genetic targeting of FABP5 or pharmacological inhibition of STING alleviates epileptic phenotypes, highlighting a potential therapeutic strategy for epilepsy.
Chen Chen, Yao Zhao, Yangye Lian, Yifei Hou, Lifen Gong, Tingting Wu, Yulin Yang, Jiaqi Zhu, Xin Wang, Kaihua Zhang, Jing Ding   +10 more
wiley   +1 more source

The effects of levetiracetam and a new 4-phenylpyrrolidone derivative GIZh-290 in a closed cross-maze in BALB/c and C57BL / 6 mice

Фармакокинетика и Фармакодинамика, 2017
The study was aimed to compare the psychopharmacological effects of 2 anticonvulsant drugs levetiracetam ((S)-2-(2-oxopyrrolidin-1-yl) butanamide) and the new compound, GIZh-290 (2-oxo-4-phenylpyrrolidine-1-yl) acetic acid) on behavioral spectra of ...
I. G. Kovalev, E. V. Vasileva, R. O. Bokov, R. M. Salimov, G. I. Kovalev   +4 more
doaj  

Clinical, Behavioral and Neuroradiological Phenotype in an Italian Cohort of Patients With Xia Gibbs Syndrome: A Multicenter Cross‐Sectional Study and Systematic Literature Review

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Heterozygous variants in the AHDC1 gene are associated with Xia Gibbs Syndrome (XGS), a genetic disorder with a highly variable phenotype. Cognitive impairment, motor delay, language delay, neonatal hypotonia, and sleep apnea are considered “cardinal” signs of the disease.
Giulia Cinelli, Stefania Della Vecchia, Patrizia Bergonzini, Elisa Caramaschi, Elisabetta Spezia, Claudia Parenti, Simona Filomena Madeo, Laura Lucaccioni, Cavalleri Francesca, Marisa Pugliese, Federico Raviglione, Clara Colonna, Olga Calabrese, Ilaria Stanghellini, Maria Carmen Marongiu, Enrico Biagioni, Anna Rita Ferrari, Roberta Battini, Lorenzo Iughetti   +18 more
wiley   +1 more source