Results 81 to 90 of about 53,577 (300)
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 Histamine H3 receptors (H3R) antagonists/inverse agonists are becoming a promising therapeutic approach for epilepsy. In this article, novel nonimidazole H3R antagonists/inverse agonists have been designed and synthesised via hybriding the H3R ...
Mingxia Song +5 more
doaj +1 more source
When meta‐analyses mislead: Promises and pitfalls in teratology counselling
British Journal of Clinical Pharmacology, EarlyView.Meta‐analysis has become a central tool for evidence synthesis in clinical teratology, offering the promise of increased statistical power, earlier signal detection and consolidated guidance for teratology counselling. When conducted rigorously and interpreted carefully, pooled analyses can provide clinicians with a structured basis for risk ...
Yusuf Cem Kaplan, Nusret Uysal
wiley +1 more source
A clinical study of 57 children with fetal anticonvulsant syndromes
, 2000 Background - Anticonvulsants taken in pregnancy are associated with an increased risk of malformations and developmental delay in the children. To evaluate the pattern of abnormalities associated with prenatal anticonvulsant exposure further, we ...
Glover S +6 more
core +4 more sources
Editorial: Pharmaceutical insights into the triazoles: Recent advances
Frontiers in Chemistry, 2023 Xianqing Deng +2 more
doaj +1 more source
Antiepileptic Drug Discovery and Development: What Have We Learned and Where Are We Going?
Pharmaceuticals, 2010 Current marketed antiepileptic drugs (AEDs) consist of a variety of structural classes with different mechanisms of action. These agents typically have non-overlapping efficacy and side-effect profiles presenting multiple treatment options for the ...
Jeffrey L. Krajewski, Aaron C. Gerlach
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims Careful consideration of drug–drug interactions (DDIs) is critical as people with HIV age. We analysed queries submitted to the University of Liverpool HIV Drug Interactions Database to assess changes in prescribing patterns over 5 years. Methods Queries submitted between January 2020 and December 2024 were extracted and categorized by year ...
Cecile Gras +6 more
wiley +1 more source
The Anticonvulsant Effects of Baldrinal on Pilocarpine-Induced convulsion in Adult Male Mice
Molecules, 2019 Epilepsy is a prevalent neurological disorder that was reported to affect about 56 million people in the world. Approximately one-third of the epileptic patients that suffer from seizures do not receive effective medical treatment.
Xiao Zhang +8 more
doaj +1 more source
Anticonvulsant actions of deoxycorticosterone in infant rats [PDF]
, 2003 The anticonvulsant actions of deoxycorticosterone (DOC) are well known, however, DOC's mechanism of action is not clear. The present study investigated DOC's anticonvulsant actions in fifteen-day-old rats.
Perez-Cruz, Claudia
core +1 more source
Lenacapavir initiation with concomitant primidone: A case report with therapeutic drug monitoring
British Journal of Clinical Pharmacology, EarlyView.Lenacapavir (LEN), a first‐in‐class capsid inhibitor, has unique pharmacokinetics that enable twice‐yearly dosing. LEN is not extensively metabolized, although it is a substrate of CYP3A4, which introduces drug–drug interactions concerns. As adoption and implementation of LEN for treatment and prevention increase, additional guidance on concomitant ...
Aaron S. Devanathan +6 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aim This study aimed to describe the pharmacokinetics (PK) of levetiracetam (LEV) in term neonates treated for neonatal seizures secondary to hypoxic–ischemic encephalopathy (HIE). Methods Fifteen neonates were included and received a loading dose ranging from 30 to 60 mg/kg followed by eight maintenance doses corresponding to one‐fourth of the loading
Léo Mimram +9 more
wiley +1 more source