Results 91 to 100 of about 47,981 (309)

1,2,3,-Triazole Anticonvulsant Drugs [PDF]

, 1986
Anticonvulsant compositions comprise as the active ingredient a compound . . .
Kadaba, Pankaja K.
core   +1 more source

Potent Anticonvulsant Urea Derivatives of Constitutional Isomers of Valproic Acid [PDF]

, 2016
Valproic acid (VPA) is a major antiepileptic drug (AED); however, its use is limited by two life-threatening side effects: teratogenicity and hepatotoxicity.
Boris Yagen (2100577), Bogdan Wlodarczyk (2296123), Richard H. Finnell (179831), Jakob Avi Shimshoni (1657873), Meir Bialer (2100580)   +4 more
core   +1 more source

Therapeutic drug monitoring of antimicrobials in a paediatric setting: A retrospective single‐centre study

British Journal of Clinical Pharmacology, EarlyView.
Aims Paediatric pharmacokinetics differ significantly from adults due to age‐related physiological changes, necessitating precise dose adjustments. However, data on therapeutic drug monitoring (TDM) implementation in paediatric setting remain limited.
Gianluca Gazzaniga, Stefano Agliardi, Riccardo Giossi, Alice Schianchi, Alessandra Romandini, Thomas Virdis, Silvia Nerini Molteni, Maria Luisa De Angelis, Stefania Paccagnini, Cecilia Gechtman, Alice Proto, Marco Fossati, Silvia Oliveri, Giulia Angela Pattarino, Elena Altieri, Agnese Graziosi, Arianna Pani, Romano Danesi, Stefano Martinelli, Costantino De Giacomo, Francesco Scaglione   +20 more
wiley   +1 more source

Triazoline Anticonvulsant Drugs [PDF]

, 1985
Anticonvulsant compositions comprise as the active ingredient a compound . . .
Kadaba, Pankaja K.
core   +1 more source

Increasing the reporting of adverse drug reaction‐related hospitalizations using an ICD‐10‐based identification workflow: A multicentre study from Switzerland

British Journal of Clinical Pharmacology, EarlyView.
Background Reporting adverse drug reactions (ADRs) is essential for drug safety. In Switzerland, healthcare professionals are legally required to report serious and unlabelled ADRs, yet under‐reporting remains widespread. We tested a novel method to increase reporting of ADR‐related hospitalizations.
Georgia Anita Weber, Sophie‐Charlotte Bartel, Michael Boch, Christoph Rosen, Michael Bodmer, Balthasar Luzius Hug, Thomas Stammschulte, Patrick E. Beeler   +7 more
wiley   +1 more source

Seizure threshold, hormones and anti epileptic drugs

Universa Medicina, 2008
The concept of seizure threshold holds that everyone has a certain balance between excitatory and inhibitory forces in the brain. A low seizure threshold makes it easier for epilepsy to develop and easier for someone to elicit single seizure.
Harsono Harsono
doaj   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Hematopoietic effects of spleen lymphocytes treated with an original anticonvulsant during long-term alcohol consumption

Медицинская иммунология
Excessive alcohol consumption has a negative effect on hematopoiesis, which manifests with significant suppression of both blood cell production, and structural changes in hematopoietic precursors, i.e., by suppression of their maturation, up to ...
I. A. Orlovskaya, E. V. Markova, I. V. Savkin, L. B. Toporkova, M. A. Knyazheva, E. V. Serenko, A. V. Smyk, E. V. Goiman   +7 more
doaj   +1 more source

Cyclooxygenase-1 as a potential therapeutic target for seizure suppression: evidences from zebrafish pentylenetetrazole-seizure model

Frontiers in Neurology, 2016
Cyclooxygenases (COX) -1 and -2 are isoenzymes that catalyze the conversion of arachidonic acid into prostaglandins (PGs). COX-2 and PGs are rapidly increased following seizures and are known to play important roles in the neuroinflammatory process.
Patricia Gonçalves Barbalho, Benilton de Sá Carvalho, Iscia Lopes-Cendes, Claudia Vianna Maurer-Morelli   +3 more
doaj   +1 more source

SISTER-CHROMATID EXCHANGES IN EPILEPTIC PATIENTS ON ANTICONVULSANT THERAPY [PDF]

, 1994
Sister-chromatid exchanges (SCE) have been studied to analyze genotoxic effects in epileptic patients on anticonvulsant therapy. All patients had an increased frequency of SCE per metaphase (p < 0.001) compared to controls, indicating a genotoxic effect ...
AYDIN, N, SARDAS, S, KARAKAYA, AE, ADA, M   +3 more
core   +1 more source