Results 111 to 120 of about 47,981 (309)
Chemistry – A European Journal, EarlyView.Can hydrophobic, shape‐selective zeolites efficiently remove the persistent pharmaceutical CBZ from water? This work moves beyond the static picture of interaction energies by modeling diffusion with umbrella sampling and machine‐learned potentials. Even high intrinsic diffusion barriers can be overcome through exergonic adsorption from water, yielding
Jakob Brauer +4 more
wiley +1 more source
Triazoline Anticonvulsant Compounds and Compositions [PDF]
, 1987 Anticonvulsant compositions comprise as the active ingredient a compound . . .
Kadaba, Pankaja K.
core +1 more source
Nerve agents: A clear and present danger to mankind [PDF]
Scripta Medica, 2019 This editorial is written on the occasion of the 25th anniversary of the infamous sarin and VX terrorist attacks in Japan, in order to increase the awareness of the potential terrorist use of nerve agents and to urge the preparedness to cope with its ...
Stojiljković Miloš P.
doaj
Clinical Pharmacology &Therapeutics, EarlyView.One‐third of epilepsy patients remain treatment‐resistant, underscoring the need for novel anti‐seizure medications (ASMs) and reliable biomarkers of central target engagement. Cortical hyperexcitability is a hallmark of epilepsy, making excitability a valuable pharmacodynamic biomarker for early‐phase drug development supporting go/no‐go decision ...
Catherine M. E. de Cuba +7 more
wiley +1 more source
Study of anticonvulsant activity of acetazolamide on albino rats and its influence on anticonvulsant activity of sodium valproate [PDF]
, 2018 Background: Epilepsy is a common neurological disorder. 30-40% of patients will continue to have seizures despite the use of antiepileptic drugs either alone or in combination.
K. H., Hemanth Kumar +3 more
core +2 more sources
Clinical Pharmacology &Therapeutics, EarlyView.Personalized dosing is particularly important for drugs with narrow therapeutic indices in geriatric patients, who exhibit substantial physiological variability and limited pharmacokinetic (PK) evidence to guide individualized dose selection. Valproic acid (VPA) is an effective treatment option for bipolar disorder in older adults, yet dosing largely ...
Yoo Jin Jang +2 more
wiley +1 more source
Phyto-pharmacological review of Portulaca quadrifida Linn.
Journal of Applied Pharmaceutical Research, 2013 Portulaca quadrifida Linn. (Family: Portuleacea), commonly known as “Chicken Weed”, a traditional medicinal plant has been used in the Ayurvedic system of medicine for centuries, valued for its benefits in the management of urinary and inflammatory ...
Mrinmay Das, Ashok Kumar D.
doaj
Population Genomics Insights into Pharmacogenomic Differentiation Between East Asians and Europeans
Clinical Pharmacology &Therapeutics, EarlyView.Genetic variation contributes substantially to interindividual and interpopulation differences in drug response, yet most pharmacogenomic studies remain biased toward European populations. Here, we systematically assessed pharmacogenomic variation across East Asians (EAS) and Europeans (EUR) using public genomic datasets and investigated the potential ...
Sihan Chen, Hongpu Chen, Shuhua Xu
wiley +1 more source
Effect of nobiletin on experimental model of epilepsy
Translational Neuroscience, 2018 The effects of nobiletin, a plant-derived flavonoid was examined against pentylenetetrazole (PTZ)-induced seizures. The study also aimed to assess whether nobiletin potentiated the effects of antiepileptic drug clonazepam (CZP).
Yang Baowang, Wang Jing, Zhang Ni
doaj +1 more source
Strengthening Pharmacovigilance Reporting for Withdrawal Reactions to Support Deprescribing
Clinical Pharmacology &Therapeutics, EarlyView.Pharmacovigilance plays a crucial role in post‐marketing surveillance of medicines and relies on the spontaneous reporting of adverse drug reactions (ADRs). Discontinuation of a drug can cause clinically relevant signs and symptoms, including withdrawal reactions; however, this subset of ADRs is not fully accommodated in current pharmacovigilance ...
Zakir Khan, Frank Moriarty
wiley +1 more source