Results 31 to 40 of about 47,981 (309)

Essential oils and their constituents: anticonvulsant activity [PDF]

, 2011
A literature-based survey of plants species and their essential oils with anticonvulsant activity was carried out. As results, 30 species belonging to 13 families and 23 genera were identified for their activities in the experimental models used for ...
Agra, Maria de Fátima, Maior, Flávia Negromonte Souto, Almeida, Reinaldo Nóbrega de, Sousa, Damião Pergentino de   +3 more
core   +3 more sources

Preparation of Nanocrystals for Insoluble Drugs by Top-Down Nanotechnology with Improved Solubility and Bioavailability

Molecules, 2020
Midazolam is a rapidly effective benzodiazepine drug that is widely used as a sedative worldwide. Due to its poor solubility in a neutral aqueous solution, the clinical use of midazolam is significantly limited.
Xun Zhang, Zhiguo Li, Jing Gao, Zengming Wang, Xiang Gao, Nan Liu, Meng Li, Hui Zhang, Aiping Zheng   +8 more
doaj   +1 more source

Anticonvulsants for tinnitus [PDF]

Cochrane Database of Systematic Reviews, 2009
Tinnitus is the perception of sound or noise in the absence of an external or internal acoustic stimulation. It is a common and potentially distressing symptom for which no adequate therapy exists.To assess the effectiveness of anticonvulsants in patients with chronic tinnitus.We searched the Cochrane Ear, Nose and Throat Disorders Group Specialised ...
Hoekstra, C.E., Rynja, S.P., Zanten, G.A., Rovers, M.M., Rovers, M.M.   +4 more
openaire   +5 more sources

Synthesis and Biological Evaluation of Novel Benzothiazole Derivatives as Potential Anticonvulsant Agents

Molecules, 2016
New benztriazoles with a mercapto-triazole and other heterocycle substituents were synthesized and evaluated for their anticonvulsant activity and neurotoxicity by using the maximal electroshock (MES), subcutaneous pentylenetetrazole (scPTZ), and rotarod
Da-Chuan Liu, Hong-Jian Zhang, Chun-Mei Jin, Zhe-Shan Quan   +3 more
doaj   +1 more source

Continuous rate infusion of midazolam as emergent treatment for seizures in dogs

Journal of Veterinary Internal Medicine, 2021
Background Midazolam delivered by continuous rate infusion (CRI) might be effective in dogs with cluster seizures (CS) or status epilepticus (SE). Objective To describe the use and safety of midazolam CRI in dogs with CS or SE.
Kathryn Y. Bray, Christopher L. Mariani, Peter J. Early, Karen R. Muñana, Natasha J. Olby   +4 more
doaj   +1 more source

Contribution of Attenuation of TNF-α and NF-κB in the Anti-Epileptic, Anti-Apoptotic and Neuroprotective Potential of Rosa webbiana Fruit and Its Chitosan Encapsulation

Molecules, 2021
Rosa webbiana L. (Rosaceae) is one of the least reported and most understudied members of this family. It is native to the Himalayan regions of Pakistan and Nepal.
Anum Firdous, Sadia Sarwar, Fawad Ali Shah, Sobia Tabasum, Alam Zeb, Humaira Nadeem, Abir Alamro, Amani Ahmed Alghamdi, Arooj Mohsin Alvi, Komal Naeem, Muhammad Sohaib Khalid   +10 more
doaj   +1 more source

Tetrazolium Compounds: Synthesis and Applications in Medicine

Molecules, 2015
Tetrazoles represent a class of five-membered heterocyclic compounds with polynitrogen electron-rich planar structural features. This special structure makes tetrazole derivatives useful drugs, explosives, and other functional materials with a wide range
Cheng-Xi Wei, Ming Bian, Guo-Hua Gong
doaj   +1 more source

Treating Epilepsy with Natural Products: Nonsense or Possibility?

Pharmaceuticals, 2023
Epilepsy is a neurological disease characterized by recurrent seizures that can lead to uncontrollable muscle twitching, changes in sensitivity to sensory perceptions, and disorders of consciousness.
Milan Malaník, Marie Čulenová, Alice Sychrová, Adrianna Skiba, Krystyna Skalicka-Woźniak, Karel Šmejkal   +5 more
doaj   +1 more source

Anticonvulsant activity of some vanilloid receptor agonists [PDF]

, 2014
Background: Vanilloid receptors 1 (VR 1), a group of transient receptor potential channels family was cloned in 1997. They were found to be a potential target for treatment of different acute and chronic pain disorder.
El-hadiyah, TMH, Ahmed, EM, Awad, EM
core   +2 more sources

Anticonvulsant Activity of Aqueous Extract of Andrographis paniculata Leaves in Wistar Albino Rats

National Board of Examinations Journal of Medical Sciences
Background: The anticonvulsant effect of Aqueous Extract of Andrographis paniculata leaves (AEAP) and its synergistic action with Sodium valproate were evaluated in this research. Methods: Anticonvulsant activity of AEAP 500 mg/kg b.w.
M S Umamageswari, S Bhuvaneshwari, A T Sathiya vinotha, T P Kalaniti, A Vijayamathy, M Murugan, T M Karthikeyan   +6 more
doaj   +1 more source