Results 31 to 40 of about 84,044 (310)

Anticonvulsants for tinnitus [PDF]

Cochrane Database of Systematic Reviews, 2009
Tinnitus is the perception of sound or noise in the absence of an external or internal acoustic stimulation. It is a common and potentially distressing symptom for which no adequate therapy exists.To assess the effectiveness of anticonvulsants in patients with chronic tinnitus.We searched the Cochrane Ear, Nose and Throat Disorders Group Specialised ...
Hoekstra, C.E., Rynja, S.P., Zanten, G.A., Rovers, M.M., Rovers, M.M.   +4 more
openaire   +5 more sources

Meralgia parestésica secundária a laparoscopia cirúrgica para miomectomia. Relato de caso

Revista Dor
JUSTIFICATIVA E OBJETIVOS: Meralgia parestésica é uma síndrome disestésica e/ou de anestesia na distribuição do nervo cutâneo femoral lateral. É uma mononeuropatia compressiva ou traumática, caracterizada por dor em queimação e/ou desconforto na face ...
Léa Menezes Couceiro, Luíza Helena Castelo Branco, Tania Cursino de Menezes Couceiro, Roberto de Oliveira Couceiro Filho   +3 more
doaj   +1 more source

A novel anticonvulsant mechanism via inhibition of complement receptor C5ar1 in murine epilepsy models.

Neurobiology of Disease, 2015
The role of complement system-mediated inflammation is of key interest in seizure and epilepsy pathophysiology, but its therapeutic potential has not yet been explored.
M. Benson, N. K. Thomas, S. Talwar, M. Hodson, J. Lynch, T. Woodruff, K. Borges   +6 more
semanticscholar   +1 more source

Nerve agents: A clear and present danger to mankind [PDF]

Scripta Medica, 2019
This editorial is written on the occasion of the 25th anniversary of the infamous sarin and VX terrorist attacks in Japan, in order to increase the awareness of the potential terrorist use of nerve agents and to urge the preparedness to cope with its ...
Stojiljković Miloš P.
doaj  

Novel 2-substituted-5-(4-chloro-2-phenoxy)phenyl-1,3,4-oxadiazole derivatives, ligands of GABAA/benzodiazepine receptor complex

EXCLI Journal : Experimental and Clinical Sciences, 2023
Agonists of Benzodiazepine (BZD) receptor are exhaustively used in the control of muscle spasms, seizure, anxiety, and insomnia. BZDs have some unwanted effects; therefore, the development of new BZD receptor agonists with better efficacy and fewer ...
Elham Rezaee, Fatemeh Ahmadi, Mahsa Shabaninia, Mona Khoramjouy, Zahra Azizi Farsani, Soraya Shahhosseini, Sayyed Abbas Tabatabai, Mehrdad Faizi   +7 more
doaj   +1 more source

Computational repositioning of the anticonvulsant topiramate for inflammatory bowel disease

Science Translational Medicine, 2011
Computationally predicted repositioning of an anticonvulsant for inflammatory bowel disease is confirmed experimentally. Greening Drug Discovery Recycling is good for the environment—and for drug development too.
J. Dudley, M. Sirota, M. Shenoy, R. Pai, S. Roedder, Annie P. Chiang, Alexander A. Morgan, M. Sarwal, P. Pasricha, A. Butte   +9 more
semanticscholar   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Effect of nobiletin on experimental model of epilepsy

Translational Neuroscience, 2018
The effects of nobiletin, a plant-derived flavonoid was examined against pentylenetetrazole (PTZ)-induced seizures. The study also aimed to assess whether nobiletin potentiated the effects of antiepileptic drug clonazepam (CZP).
Yang Baowang, Wang Jing, Zhang Ni
doaj   +1 more source

Unusual Presentation of Seizure in a Child: A Case of Abdominal Epilepsy and Associated Diagnostic Dilemmas [PDF]

Journal of Clinical and Diagnostic Research
Abdominal Epilepsy (AE) is a rare and often under-recognised form of epilepsy that typically presents in children with gastrointestinal symptoms, such as recurrent vomiting.
M Sherin Fathima, R Ramya, S Sundari
doaj   +1 more source