Results 31 to 40 of about 78,762 (304)

Preparation of Nanocrystals for Insoluble Drugs by Top-Down Nanotechnology with Improved Solubility and Bioavailability

Molecules, 2020
Midazolam is a rapidly effective benzodiazepine drug that is widely used as a sedative worldwide. Due to its poor solubility in a neutral aqueous solution, the clinical use of midazolam is significantly limited.
Xun Zhang, Zhiguo Li, Jing Gao, Zengming Wang, Xiang Gao, Nan Liu, Meng Li, Hui Zhang, Aiping Zheng   +8 more
doaj   +1 more source

Tetrazolium Compounds: Synthesis and Applications in Medicine

Molecules, 2015
Tetrazoles represent a class of five-membered heterocyclic compounds with polynitrogen electron-rich planar structural features. This special structure makes tetrazole derivatives useful drugs, explosives, and other functional materials with a wide range
Cheng-Xi Wei, Ming Bian, Guo-Hua Gong
doaj   +1 more source

Olivetolic acid, a cannabinoid precursor in Cannabis sativa, but not CBGA methyl ester exhibits a modest anticonvulsant effect in a mouse model of Dravet syndrome

Journal of Cannabis Research, 2022
Objective Cannabigerolic acid (CBGA), a precursor cannabinoid in Cannabis sativa, has recently been found to have anticonvulsant properties in the Scn1a +/- mouse model of Dravet syndrome.
Lyndsey L. Anderson, Michael Udoh, Declan Everett-Morgan, Marika Heblinski, Iain S. McGregor, Samuel D. Banister, Jonathon C. Arnold   +6 more
doaj   +1 more source

Contribution of Attenuation of TNF-α and NF-κB in the Anti-Epileptic, Anti-Apoptotic and Neuroprotective Potential of Rosa webbiana Fruit and Its Chitosan Encapsulation

Molecules, 2021
Rosa webbiana L. (Rosaceae) is one of the least reported and most understudied members of this family. It is native to the Himalayan regions of Pakistan and Nepal.
Anum Firdous, Sadia Sarwar, Fawad Ali Shah, Sobia Tabasum, Alam Zeb, Humaira Nadeem, Abir Alamro, Amani Ahmed Alghamdi, Arooj Mohsin Alvi, Komal Naeem, Muhammad Sohaib Khalid   +10 more
doaj   +1 more source

Antiepileptic drugs reduce serum uric acid [PDF]

, 1987
Uric acid examination in 554 epileptic out-patients under long-term anticonvulsant medication revealed significantly lower serum concentrations compared to a group of normal controls.
Arab, Bernhard Schellenberg, Heinrich Schmidt-Gayk, Klaus-Henning Krause, Meinardi, Peter Berlit, Richens, Yeung   +7 more
core   +1 more source

Anticonvulsant Activity of Aqueous Extract of Andrographis paniculata Leaves in Wistar Albino Rats

National Board of Examinations Journal of Medical Sciences
Background: The anticonvulsant effect of Aqueous Extract of Andrographis paniculata leaves (AEAP) and its synergistic action with Sodium valproate were evaluated in this research. Methods: Anticonvulsant activity of AEAP 500 mg/kg b.w.
M S Umamageswari, S Bhuvaneshwari, A T Sathiya vinotha, T P Kalaniti, A Vijayamathy, M Murugan, T M Karthikeyan   +6 more
doaj   +1 more source

Treating Epilepsy with Natural Products: Nonsense or Possibility?

Pharmaceuticals, 2023
Epilepsy is a neurological disease characterized by recurrent seizures that can lead to uncontrollable muscle twitching, changes in sensitivity to sensory perceptions, and disorders of consciousness.
Milan Malaník, Marie Čulenová, Alice Sychrová, Adrianna Skiba, Krystyna Skalicka-Woźniak, Karel Šmejkal   +5 more
doaj   +1 more source

Modulation of neural cell membrane conductance by the herbal anxiolytic and antiepileptic drug aswal [PDF]

, 2000
To evaluate the effects of aswal on ionic fluxes and neuronal excitation, we performed extracellular and whole cell patch clamp recordings on CA1 pyramidal neurons of guinea pigs and Long-Evans rats.
Grunze, Heinz, Langosch, J., Loewenich, C. von, Walden, Jörg   +3 more
core   +1 more source

Thiazole Ring—A Biologically Active Scaffold

Molecules, 2021
Background: Thiazole is a good pharmacophore nucleus due to its various pharmaceutical applications. Its derivatives have a wide range of biological activities such as antioxidant, analgesic, and antimicrobial including antibacterial, antifungal ...
Anthi Petrou, Maria Fesatidou, Athina Geronikaki   +2 more
doaj   +1 more source

Female genital disorder as adverse symptom of lamotrigine treatment - A serotoninergic effect? [PDF]

, 1998
The new anticonvulsant, lamotrigine, is becoming an important tool in the treatment of bipolar disorder, including bipolar depression. Its efficacy in bipolar depression might be linked to its inhibition of serotonin uptake.
Amann, Benedikt, Erfurth, Andreas, Grunze, Heinz   +2 more
core   +1 more source