Results 11 to 20 of about 84,044 (310)

The Neuroactive Steroid Pregnanolone Glutamate: Anticonvulsant Effect, Metabolites and Its Effect on Neurosteroid Levels in Developing Rat Brains

Pharmaceuticals, 2021
Pregnanolone glutamate (PA-G) is a neuroactive steroid that has been previously demonstrated to be a potent neuroprotective compound in several biological models in vivo.
Eva Kudova, Pavel Mares, Martin Hill, Katerina Vondrakova, Grygoriy Tsenov, Hana Chodounska, Hana Kubova, Karel Vales   +7 more
doaj   +1 more source

Comparison of Magnesium Sulphate Protocols by Weight-Adjusted Versus Two Grams Per Hour for Preventing Convulsion in Preeclampsia: A Randomised Controlled Trial [PDF]

Journal of Clinical and Diagnostic Research, 2019
Introduction: Magnesium Sulphate (MgSO4 ) is the most effective drug used for seizure prevention in preeclampsia; however, the dosage of MgSO4 is still in controversy.
Saowanee Tangmanowutthikul, Rawisara Champawong, Srisuda Songthamwat, Metha Songthamwat   +3 more
doaj   +1 more source

The original anticonvulsant meta-Cl-benzhydrylurea (m-CL-BHM) induces of the liver monooxygenase system and stimulates the neuroimmune response in behavioral disorders of alcoholic origin

European Psychiatry, 2022
Introduction The anticonvulsant m-Cl-BHM is promising for the pathogenetically directed thrapy does not cause negative effects. Objectives Investigation of the effect of m-Сl-BHM on “immunochemical homeostasis” in rats with experimental alcoholism ...
Т. Shushpanova, T. Novozheeva, E. Gutkevich, A. Pustovaya, N. Garganeeva, M. Belousov, A. Podyablonsky, E. Markova, E. Knyazeva, O. Shushpanova, N. Kolomiets, S. Safronov, R. Boev   +12 more
doaj   +1 more source

Randomized Trial of Three Anticonvulsant Medications for Status Epilepticus

New England Journal of Medicine, 2019
BACKGROUND The choice of drugs for patients with status epilepticus that is refractory to treatment with benzodiazepines has not been thoroughly studied.
J. Kapur, J. Elm, J. Chamberlain, William Barsan, J. Cloyd, D. Lowenstein, S. Shinnar, R. Conwit, Caitlyn Meinzer, Hannah R Cock, N. Fountain, J. Connor, R. Silbergleit   +12 more
semanticscholar   +1 more source

Impaired cognitive ability and anxiety-like behavior following acute seizures in the Theiler's virus model of temporal lobe epilepsy

Neurobiology of Disease, 2014
Viral infection of the CNS can result in encephalitis and acute seizures, increasing the risk for later-life epilepsy. We have previously characterized a novel animal model of temporal lobe epilepsy that recapitulates key sequela in the development of ...
Anthony D. Umpierre, Gregory J. Remigio, E. Jill Dahle, Kate Bradford, Anitha B. Alex, Misty D. Smith, Peter J. West, H. Steve White, Karen S. Wilcox   +8 more
doaj   +1 more source

Bromide Dose in Dogs With Epilepsy Living Close to Coastal Areas and Living More Inland: A Retrospective Observational Study

Frontiers in Veterinary Science, 2022
Potassium bromide is a frequently used antiseizure medication with a half-life time of over 25 days. Oral intake of sodium chloride as well as renal function influence this half-life time and may have an influence on the needed dose to get proper serum ...
Esther A. Lichtenauer, Bas Evers, Jan van den Broek, Paul J. J. Mandigers, Paul J. J. Mandigers   +4 more
doaj   +1 more source

Histone Deacetylase Is a Direct Target of Valproic Acid, a Potent Anticonvulsant, Mood Stabilizer, and Teratogen*

Journal of Biological Chemistry, 2001
Valproic acid is widely used to treat epilepsy and bipolar disorder and is also a potent teratogen, but its mechanisms of action in any of these settings are unknown. We report that valproic acid activates Wntdependent gene expression, similar to lithium,
C. Phiel, Fang Zhang, E. Huang, M. Guenther, M. Lazar, P. S. Klein   +5 more
semanticscholar   +1 more source

Design, Synthesis, and Evaluation of Anticonvulsant Activities of New Triazolopyrimidine Derivatives

Frontiers in Chemistry, 2022
Epilepsy, a severe brain disease affecting a large population, is treated mainly by antiepileptic drugs (AEDs). However, toxicity, intolerance, and low efficiency of the available AEDs have prompted the continual attempts in the discovery of new AEDs. In
Mingxia Song, Mingxia Song, Wennan Zhao, Yangnv Zhu, Wenli Liu, Xianqing Deng, Xianqing Deng, Yushan Huang   +7 more
doaj   +1 more source

Anticonvulsant Essential Oils and Their Relationship with Oxidative Stress in Epilepsy

Biomolecules, 2019
Epilepsy is a most disabling neurological disorder affecting all age groups. Among the various mechanisms that may result in epilepsy, neuronal hyperexcitability and oxidative injury produced by an excessive formation of free radicals may play a role in ...
Diogo Vilar da Fonsêca, Carlos da Silva Maia Bezerra Filho, T. Lima, R. N. de Almeida, D. D. de Sousa   +4 more
semanticscholar   +1 more source

Evaluation of antiseizure drug efficacy and tolerability in the rat lamotrigine‐resistant amygdala kindling model

Epilepsia Open, 2019
Objective The lamotrigine‐resistant amygdala kindling model uses repeated administration of a low dose of lamotrigine during the kindling process to produce resistance to lamotrigine, which also extends to some other antiseizure drugs (ASDs).
Cameron S. Metcalf, Jennifer Huff, Kyle E. Thomson, Kristina Johnson, Sharon F. Edwards, Karen S. Wilcox   +5 more
doaj   +1 more source