Results 241 to 250 of about 114,909 (286)
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CEPHALOSPORINS, CARBAPENEMS, AND MONOBACTAMS
Infectious Disease Clinics of North America, 2000Nonpenicillin beta-lactams exhibit a variable spectrum of antimicrobial activity, have a wide range of clinical uses and a favorable safety profile. Cefepime's twice-daily dosage and increased activity against Enterobacteriaceae may offer some advantages over older cephalosporins.
L E, Asbel, M E, Levison
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Carbapenem-based prodrugs. Design, synthesis, and biological evaluation of carbapenems
European Journal of Medicinal Chemistry, 2005Syntheses of racemic trans-3-hydroxycarbonyl-6-(phenylacetamido)carbapenem (13), trans-3-phosphono-6-(phenylacetamido)carbapenem (17), and beta-lactam based prodrugs 19 and 22 were accomplished. Carbapenem 13 was found to possess antibacterial activity, comparable with imipenem (+)-3, against Staphylococcus aureus FDA 209P, S.
Gholam Hossein, Hakimelahi +5 more
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Current Status of Newer Carbapenems
Current Medicinal Chemistry, 2009Beta-lactam antibiotics represent the most commonly prescribed antibacterial agents. Since many bacteria have developed resistance to older agents, new beta-lactams have been introduced constantly. In the late 1970s, a new class of exceptionally broad-spectrum beta-lactams, the carbapenems, was identified.
BASSETTI M +4 more
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Journal of Infection and Chemotherapy, 2018
The emergence and dissemination of antimicrobial resistance is a worldwide problem. Inappropriate antimicrobial use contributes to this resistance, and several metrics of drug usage have been used to monitor their consumption and rational use. We examined several existing drug metrics, and developed a new one, dose/duration-density (D/d2), for a the ...
Shinobu Hirayama +10 more
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The emergence and dissemination of antimicrobial resistance is a worldwide problem. Inappropriate antimicrobial use contributes to this resistance, and several metrics of drug usage have been used to monitor their consumption and rational use. We examined several existing drug metrics, and developed a new one, dose/duration-density (D/d2), for a the ...
Shinobu Hirayama +10 more
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Expert Opinion on Investigational Drugs, 2001
Ertapenem is a new 1-beta-methyl carbapenem, stable to dehydropeptidase, which binds preferable to penicillin-binding proteins (PBP) 2 and 3. Ertapenem has a broad antibacterial spectrum with MIC90 values < 0.5 mg/l for penicillin-susceptible Streptococcus pneumoniae, Streptococcus pyogenes, methicillin-sensitive Staphylococcus aureus, Haemophilus ...
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Ertapenem is a new 1-beta-methyl carbapenem, stable to dehydropeptidase, which binds preferable to penicillin-binding proteins (PBP) 2 and 3. Ertapenem has a broad antibacterial spectrum with MIC90 values < 0.5 mg/l for penicillin-susceptible Streptococcus pneumoniae, Streptococcus pyogenes, methicillin-sensitive Staphylococcus aureus, Haemophilus ...
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Neurotoxicity of Carbapenem Antibacterials
Drug Safety, 1996Similar to other beta-lactam antibacterials, carbapenems have a neurotoxic potential that seems to be higher than that of the penicillins and cephalosporins. Seizures have been reported in several large studies of patients treated with imipenem/cilastatin.
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Seminars in Pediatric Infectious Diseases, 2001
Katherine M. Knapp, B.Keith English
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Katherine M. Knapp, B.Keith English
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Carbapenems for Surgical Prophylaxis?
New England Journal of Medicine, 2006In this issue of the Journal, Itani and colleagues1 describe a study in which 1002 patients were randomly assigned to receive either ertapenem or cefotetan in a single dose before elective colorectal surgery. Many experienced surgeons and hospital epidemiologists will probably be surprised that the overall rate of failure in the modified intention-to ...
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เภสัชเคมีของยาปฏิชีวนะกลุ่ม Carbapenems ; Pharmaceutical Chemistry of Antibiotics: Carbapenems
มค.-ธค., 2, ไทยไภษัชยนิพนธ์openaire +1 more source
Bacterial Resistance to Carbapenems
1995The carbapenems have the broadest spectra of all beta-lactams but resistance still occurs, caused by target modification, impermeability or beta-lactamase production. Target modification or replacement is important in methicillin-resistant staphylococci, E. faecium and some pneumococci.
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