Palladium-catalyzed regioselective C1-selective nitration of carbazoles [PDF]
Beilstein Journal of Organic ChemistryCarbazoles are ubiquitous and privileged heterocyclic scaffolds in various functional organic materials and naturally occurring products. Although extensive efforts have focused on developing synthetic strategies toward carbazole derivatives, direct ...
Vikash Kumar +5 more
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Can Fascaplysins Be Considered Analogs of Indolo[2,3-a]pyrrolo[3,4-c]carbazoles? Comparison of Biosynthesis, Biological Activity and Therapeutic Potential [PDF]
Marine DrugsFor the first time, a comparative analysis has been conducted to elucidate the biosynthesis of three families of natural products—staurosporines/rebeccamycins, cladoniamides, and fascaplysins.
Maxim E. Zhidkov +4 more
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Enantiotopic-group-selective coupling for unified access to carbazole atropisomers as versatile chiral chromophores [PDF]
Nature CommunicationsChiral organic chromophores are foundational for advanced optical and electronic devices. Despite the widespread use of N-aryl carbazoles in visible-luminescent materials, chiroptical applications of their atropisomers have remained underdeveloped due to
Junqiang Wei +3 more
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Synthesis of N-acyl carbazoles, phenoxazines and acridines from cyclic diaryliodonium salts [PDF]
Beilstein Journal of Organic ChemistryN-Acyl carbazoles can be efficiently produced through a single-step process using amides and cyclic diaryliodonium triflates. This convenient reaction is facilitated by copper iodide in p-xylene, using the commonly found activating ligand diglyme.
Nils Clamor +4 more
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Anti-Breast Cancer Properties and In Vivo Safety Profile of a Bis-Carbazole Derivative [PDF]
PharmaceuticsBackground: Carbazoles represent one of the most important classes of nitrogen-based tricyclic aromatic heterocycles and are present in natural sources and chemically obtained drugs.
Jessica Ceramella +10 more
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SynOpen, 2021 Synthetic preparation of carbazoles can be challenging, requiring ring-building strategies and/or precious metal catalysts. Presented herein is a method for the preparation of carbazoles with the use of inexpensive and reliable hypervalent iodine ...
Addison M. Duda +3 more
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Novel Small-Molecule Hybrid-Antibacterial Agents against S. aureus and MRSA Strains
Molecules, 2021 Ongoing resistance developments against antibiotics that also affect last-resort antibiotics require novel antibacterial compounds. Strategies to discover such novel structures have been dimerization or hybridization of known antibacterial agents.
Robin Gehrmann +5 more
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Beilstein Journal of Organic Chemistry, 2021 The p-TsOH-catalyzed Diels–Alder reaction of 3-(indol-3-yl)maleimides with chalcone in toluene at 60 °C afforded two diastereoisomers of tetrahydropyrrolo[3,4-c]carbazoles, which can be dehydrogenated by DDQ oxidation in acetonitrile at room temperature ...
Ren-Jie Fang +4 more
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A Nitrocarbazole as a New Microtubule-Targeting Agent in Breast Cancer Treatment
Applied Sciences, 2021 Breast cancer is still considered a high-incidence disease, and numerous are the research efforts for the development of new useful and effective therapies.
Maria Stefania Sinicropi +11 more
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Effect of Substituents of Cerium Pyrazolates and Pyrrolates on Carbon Dioxide Activation
Molecules, 2021 Homoleptic ceric pyrazolates (pz) Ce(RR’pz)4 (R = R’ = tBu; R = R’ = Ph; R = tBu, R’ = Me) were synthesized by the protonolysis reaction of Ce[N(SiHMe2)2]4 with the corresponding pyrazole derivative.
Uwe Bayer +4 more
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