Results 141 to 150 of about 4,735 (210)

Therapeutic potential of spexin in diabetic neuropathy: Insights from in vitro and in vivo models

open access: yesExperimental Physiology, EarlyView.
Abstract The present study investigated the therapeutic potential of spexin (SPX) on both in vitro and in vivo models of diabetic neuropathy (DN). A total of 40 male BALB/c mice were randomly allocated into four experimental groups (n = 10 per group): a normoglycaemic control, an untreated DN group and two SPX treatment groups (DN+SPX‐12.5 and DN+SPX ...
Mehmet Refik Bahar   +5 more
wiley   +1 more source

Recent advances in the stereoselective synthesis of distal biaxially chiral molecules. [PDF]

open access: yesBeilstein J Org Chem
Zhou F   +10 more
europepmc   +1 more source

Plasma Aryl Hydrocarbon Receptor Agonist Activity Is Associated With Inflammation and Metabolic Dysregulation in Obesity: A Cross‐Sectional Study

open access: yesDiabetes/Metabolism Research and Reviews, Volume 42, Issue 5, July 2026.
ABSTRACT Background The aryl hydrocarbon receptor (AhR) is linked to inflammation, but its plasma agonist activity and association with metabolic and inflammatory markers in obesity remain unclear. This cross‐sectional study aimed to determine the level of plasma AhR agonistic activity and its association with systemic inflammation and metabolic ...
Fatemah Bahman   +7 more
wiley   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

open access: yesMedicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur   +6 more
wiley   +1 more source

The role of fluvoxamine in the treatment of endotoxin‐induced acute heart injury

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 13, Page 3815-3828, July 2026.
Abstract Background and Purpose Cardiovascular diseases are among the most common health problems worldwide. Inflammation plays a critical role in the pathogenesis of various heart diseases. Lipopolysaccharides (LPS) trigger inflammatory mechanisms, leading to an inflammatory response.
Ilter Ilhan   +5 more
wiley   +1 more source

Visible Light‐Induced Transformation of β‐Aryl‐α,β‐Unsaturated Acylsilanes into Indenol Derivatives via Alkenyl Siloxycarbenes

open access: yesAdvanced Synthesis &Catalysis, Volume 368, Issue 12, 17 June 2026.
Visible light activates β‐aryl α,β‐unsaturated acylsilanes to form indenols without catalysts or metals. A stepwise photochemical cascade reorganizes simple precursors through isomerization, rearrangement, and ring formation. The process highlights sustainable reaction design while showcasing the synthetic power of acylsilane photochemistry and the ...
Adrián Álvarez   +4 more
wiley   +1 more source

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