Results 101 to 110 of about 38,785 (280)
Lesion Site‐Targeted Microspheres Modulate Nav1.7‐Related Signaling for Osteoarthritis Treatment
Advanced Science, EarlyView.Cartilage‐targeted carbamazepine‐loaded WYRGRL‐modified composite microspheres (CBZ/WCOM) anchor to exposed type II collagen in osteoarthritic lesions and release carbamazepine under acidic conditions. This bind‐then‐release platform modulates Nav1.7‐related sodium signaling, Na⁺/Ca²⁺ exchanger‐associated Ca2+ dynamics, and heat shock protein 70 ...
Cheng Chen +15 more
wiley +1 more source
A facile route to thin films of zinc carbodiimide using aerosol assisted chemical vapor deposition [PDF]
There has been a resurgence of interest in metal carbodiimides in recent years and in this paper we present a route to the synthesis of one of these phases, zinc carbodiimide, previously known as zinc cyanamide, in the form of a sub-micrometer thin film,
Hyett, Geoff +2 more
core +1 more source
Versatile Detection of Cellular Protein via Fluorescence Anisotropy
Advanced Science, EarlyView.Cell Lysate Fluorescence Anisotropy (CFAST) utilizes long lifetime dye‐labeled nanobodies for rapid protein quantification in minimally purified, complex cell lysate. When coupled with cellular thermal shift, CFAST allows high‐throughput detection of endogenous protein‐small molecule engagement, facilitating the discovery of novel binders for ...
Qing Tang +12 more
wiley +1 more source
Carbodiimide production from cyanamide by UV irradiation and thermal reaction on amorphous water ice [PDF]
, 2005 International audienceCyanamide (NH2CN), an interstellar molecule, is a relevant molecule in prebiotic chemistry, because it can be converted into urea in liquid water. Carbodiimide (HNCNH) the most stable cyanamide isomer.
Chiavassa, Thierry +3 more
core +1 more source
Advanced Science, EarlyView.This study identifies C4 as a lead inhibitor of the Lpt system. Notably, C4 potentiates colistin activity by disrupting LPS transport and remodeling phospholipid homeostasis, revealing a functional interplay between the Lpt and Mla systems. These findings establish a mechanistic link between Lpt inhibition and membrane lipid remodeling, positioning Lpt–
Jianya Luo +6 more
wiley +1 more source
Sol – Gel Modelling Associated with the Rheology of Polymeric Precursors of Ceramic Materials
Applied Rheology, 2003 A general constitutive relation describing the change of viscoelastic behavior during the liquid - solid (sol - gel) transition which takes place in preceramic polymers is derived on the basis of Jeffrey’s 3-constants model with time dependent ...
Balan Corneliu, Riedel Ralf
doaj +1 more source
BioTechniques, 2005 Microarrays have been extensively used to investigate genome-wide expression patterns. Although this technology has been tremendously successful, several practical issues would benefit from improvements in design.
Naoki Kimura +2 more
doaj +1 more source
Advanced Science, EarlyView.A fully synthetic four‐component vaccine has been developed combining Tn antigen, vizantin (Mincle agonist), rhamnose (antibody recruitment), and mannose (CD206 targeting). By synergistically activating Mincle, FcγR, and CD206 pathways, it elicits strong IgG switching and cytotoxic T‐cells, significantly inhibiting tumors in mice.
Wenbo Ming +9 more
wiley +1 more source
Characterisation of collagen-derived biomaterials [PDF]
, 2009 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University on 22 May 2009.One of the main problems in healthcare is the loss or failure of organs or tissues resulting from diseases, post-surgery complications ...
de Castro Bras, Lisandra
core
Quantum Dot-Antibody Conjugates via Carbodiimide-Mediated Coupling for Cellular Imaging [PDF]
, 2014 This chapter describes the processes of antibody (Ab) production, purification, conjugation to quantum dots (QDs), and the use of the conjugates produced in intracellular imaging of cell components and structures. Specifically, information is provided on
Todd, M. +11 more
core +1 more source