Results 261 to 270 of about 41,413 (346)

A novel fusion tool to enable G protein‐coupled receptor structure determination

open access: yesActa Crystallographica Section D, Volume 82, Issue 6, Page 655-663, June 2026.
The development of a new fusion tool in which a β‐lactamase fusion tag and a binding partner enabled the structure determination of an antagonist‐bound G protein‐coupled receptor by cryo‐EM is reported.Structure determination of G protein‐coupled receptors (GPCRs) plays an important role in accelerating drug development against this medically important
Nita R. Shah   +14 more
wiley   +1 more source

Innovative Syntheses and Reactivity of Propiolamidines. [PDF]

open access: yesMolecules
Ginés C   +3 more
europepmc   +1 more source

PEGylated Chitosan Nanoparticles: Engineering Multifunctional Platforms for Targeted Cervical and Lung Cancer Treatment

open access: yesCancer Science, Volume 117, Issue 6, Page 1531-1542, June 2026.
Graphical representation of formation of self‐assembled PEGylated Chitosan Nanoparticles and their mechanism in tumor localization. ABSTRACT Polymer‐based nanocarriers have emerged as transformative platforms in cancer nanomedicine, enabling controlled and site‐specific delivery of therapeutic agents.
Prashant Kesharwani   +5 more
wiley   +1 more source

Bis(diiminate)-Supported Bimetallic Complexes: Tri-Coordinated Zinc for Nitrile and Carbodiimide Hydroboration

open access: yesACS Omega
Darakshan Parveen   +3 more
doaj   +1 more source

Push–Pull Ynamines and Push–Pull Ynamides: Synthesis, Structure, Reactivity, and Application

open access: yesEuropean Journal of Organic Chemistry, Volume 29, Issue 19, 22 May 2026.
Push–pull ynamines and push–pull ynamides, which carry an EWG and an amino or amido group as EDG, are highly interesting classes of EDG‐EWG alkynes that have been intensively studied due to their exceptional reactivity. In this review, the synthesis, structure, reactivity, and application of push–pull ynamines, push–pull ynecarbamates, push–pull ...
Hans‐Joachim Gais
wiley   +1 more source

Tandem Reactivity of Metal−Carbon and Carbon−Silicon Bonds in Mononuclear α‐Silyl Organolithium or Organosodium Complexes Towards CO, CO2 and Heteroallenes

open access: yesAngewandte Chemie, Volume 138, Issue 21, 18 May 2026.
Anionic α‐silyl alkyl is one of the most used organometallic building blocks and funtional groups. Traditionally, the C─Si bond in these complexes is considered as inert. In this work, we report a series of reactions between mononuclear organo‐lithium and ‐sodium complexes with CO, CO2, or heteroallenes.
Xiao Yang   +8 more
wiley   +2 more sources

Total Synthesis of Novel Oxylipins: Plasmodiophorols A, C, and Epimers

open access: yesEuropean Journal of Organic Chemistry, Volume 29, Issue 19, 22 May 2026.
The first total syntheses of plasmodiophorols A and C, recently identified α‐linolenic acid‐derived oxylipins, were achieved from chiral cyclopentafuranone in 12–13 steps. The routes use enzymatic desymmetrization, epimerization, and diastereoselective Grignard addition, providing stereocontrolled access to the natural products and reliable standards ...
Alexandre Guy   +3 more
wiley   +1 more source

Home - About - Disclaimer - Privacy