Results 221 to 230 of about 5,486 (323)

A Nano‐Interception Strategy for Chronic Heart Failure: Prussian Blue Nanoparticles Disrupt Fibroblast‐Immune Communication via CCL2 Sequestration

Advanced Materials, Volume 38, Issue 31, 2 June 2026.
A nano‐interception strategy disrupts pathogenic fibroblast–macrophage crosstalk in chronic heart failure. Scalable Prussian blue nanoparticles selectively sequester CCL2 via ultrahigh‐affinity binding, preventing CCR2+ macrophage recruitment and breaking a key fibro‐inflammatory circuit. This approach demonstrates robust efficacy in murine and porcine
Bo Chen, Gao Wei, Guowei Zeng, Haoyu Li, Rongrong Wu, Hongyu Yan, Zijie Zhou, Kai Luo, Xiaoyang Zhang, Cong Li, Longming Huang, Lingyan Cheng, Xinjie Zhang, Jinghao Zheng, Bozhong Shi, Xiaojun Cai, Xiaomin He   +16 more
wiley   +1 more source

Precision Labeling of Native Antibodies with Lock Coupling. [PDF]

J Am Chem Soc
Liu Y, Nadig I, Mehta AS, Chuo SW, Ho YH, Tyler J, Craik CS, Anwar M, Cohen BE.   +8 more
europepmc   +1 more source

Stimuli‐Responsive Crosslinked Chitosan/PVP/PEG Hydrogel Networks for Targeted Drug Delivery and Antimicrobial Performance

Analytical Science Advances, Volume 7, Issue 1, June 2026.
ABSTRACT In this study, a unique pH‐sensitive PEG/C/PVA hydrogel based on chitosan (C), polyvinyl propylene (PVP) and polyethylenglycol (PEG) crosslinked with tetraethyl orthosilicate (TEOS) was fabricated. This PEG/C/PVA hydrogel was designed to deliver different drugs with distinct release profiles, including diclofenac sodium and ciprofloxacin, and ...
Danial Mazhar, Sumra Afzal, Safia Hassan, Zahid Imran, Shabana Mehreen   +4 more
wiley   +1 more source

Recent Advances in Chemical Probing Strategies for RNA Structure Determination In Vivo. [PDF]

Chemistry
Yarshova M, Zhao J, Kwok CK.
europepmc   +1 more source

High‐Content Immunofluorescence Quantification of Transcription Factors: Application to pSMADs for BMP/TGFβ Signaling Pathways

Current Protocols, Volume 6, Issue 6, June 2026.
Abstract High‐throughput immunofluorescence (IF) detection has become an essential tool in drug discovery for analyzing multiple markers and providing insights into cellular pathways. While IF techniques have been established for decades, high‐content IF protocols vary among laboratories, highlighting the need for standardized and quantitative ...
Valia Khodr, Paul Machillot, Catherine Picart   +2 more
wiley   +1 more source

2-Azidobenzaldehyde-Enabled Construction of Quinazoline Derivatives: A Review. [PDF]

Int J Mol Sci
Qiu W, Zhan D, Ma X, Zhang X.
europepmc   +1 more source

Metabolic Tagging of Tumour Extracellular Vesicles for Targeted Modulation of Dendritic Cells

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
ABSTRACT Extracellular vesicles (EVs) have emerged as a promising alternative to cell‐based therapies due to their benign safety profiles and favourable pharmacokinetic properties. Tumour EVs, in particular, have shown promise to function as a therapeutic cancer vaccine for various cancer types.
Rimsha Bhatta, Wenhao Xu, Ruike Dai, Yusheng Liu, Jiadiao Zhou, Yixin Xue, Hua Wang   +6 more
wiley   +1 more source

Enhancing the Hydrolytic Stability of Poly(lactic acid) Using Novel Stabilizer Combinations. [PDF]

Polymers (Basel)
Hallstein J, Metzsch-Zilligen E, Pfaendner R.   +2 more
europepmc   +1 more source

Innovative Drug Delivery Systems for the Treatment of Glaucoma

MedComm – Biomaterials and Applications, Volume 5, Issue 2, June 2026.
This review aims to provide a comprehensive overview of current topical drug delivery strategies for ocular hypotensive agents in glaucoma therapy. Additionally, it discusses the potential impact of emerging nanotechnological and biomaterial‐based systems in shaping the future of ophthalmic drug delivery, with an emphasis on enhancing efficacy, safety,
Jing Chu, Junzhi Li, Zhenlin Chen, Jinyu Zhang, Siqi Feng, Jiaying Huang, Yawen Chu, Xue Zhou, Wei Wang, Shangsi Chen   +9 more
wiley   +1 more source

Molecular Design in l-Glutamic Acid-Based Peptide Assembly Dynamics Driven by Carbodiimide-Fueled Reaction Cycle. [PDF]

Biomacromolecules
Özbek N, Chen X, Kriebisch BAK, Fernández-de-la-Pradilla A, Świderek K, Boekhoven J, Escuder B.   +6 more
europepmc   +1 more source