A novel fusion tool to enable G protein‐coupled receptor structure determination
Acta Crystallographica Section D, Volume 82, Issue 6, Page 655-663, June 2026.The development of a new fusion tool in which a β‐lactamase fusion tag and a binding partner enabled the structure determination of an antagonist‐bound G protein‐coupled receptor by cryo‐EM is reported.Structure determination of G protein‐coupled receptors (GPCRs) plays an important role in accelerating drug development against this medically important
Nita R. Shah +14 more
wiley +1 more source
High-Pressure Synthesis of Crystalline Double-Layer Carbon Nitride Networks Stabilized in Bi<sub>7</sub>C<sub>10</sub>N<sub>18</sub>(N<sub>3(1-</sub> <sub>x</sub> <sub>)</sub>O<sub>3</sub> <sub>x</sub>). [PDF]
Angew Chem Int Ed EnglBrüning L +7 more
europepmc +1 more source
Cancer Science, Volume 117, Issue 6, Page 1531-1542, June 2026.Graphical representation of formation of self‐assembled PEGylated Chitosan Nanoparticles and their mechanism in tumor localization. ABSTRACT Polymer‐based nanocarriers have emerged as transformative platforms in cancer nanomedicine, enabling controlled and site‐specific delivery of therapeutic agents.
Prashant Kesharwani +5 more
wiley +1 more source
Reversible C─H Insertion in Bulky Unsaturated NHCs: A Carbon-Based Analogue of Oxidative Addition/Reductive Elimination. [PDF]
ChemistrySánchez A +8 more
europepmc +1 more source
Push–Pull Ynamines and Push–Pull Ynamides: Synthesis, Structure, Reactivity, and Application
European Journal of Organic Chemistry, Volume 29, Issue 19, 22 May 2026.Push–pull ynamines and push–pull ynamides, which carry an EWG and an amino or amido group as EDG, are highly interesting classes of EDG‐EWG alkynes that have been intensively studied due to their exceptional reactivity. In this review, the synthesis, structure, reactivity, and application of push–pull ynamines, push–pull ynecarbamates, push–pull ...
Hans‐Joachim Gais
wiley +1 more source
Seeing through collagen: integrative pro-regenerative corneal implants for clearer future. [PDF]
NPJ Regen MedHuang X, Islam MM, Watson SL, Patra HK.
europepmc +1 more source
Total Synthesis of Novel Oxylipins: Plasmodiophorols A, C, and Epimers
European Journal of Organic Chemistry, Volume 29, Issue 19, 22 May 2026.The first total syntheses of plasmodiophorols A and C, recently identified α‐linolenic acid‐derived oxylipins, were achieved from chiral cyclopentafuranone in 12–13 steps. The routes use enzymatic desymmetrization, epimerization, and diastereoselective Grignard addition, providing stereocontrolled access to the natural products and reliable standards ...
Alexandre Guy +3 more
wiley +1 more source
A heterometallic σ-silane adduct from cooperative reactivity of an iron-aluminium complex.
Chem Commun (Camb)Stadler B, Crimmin MR.
europepmc +1 more source
Recent Approaches for the Synthesis of Pyridine and Quinoline Cores Present in Natural Products
Advanced Synthesis &Catalysis, Volume 368, Issue 10, 19 May 2026.An anthology of the most recent methods used to synthesize pyridines and quinolines found in natural products over the last decade. Pyridines, quinolines, and their derivatives represent a class of significant heterocyclic compounds that are prevalent in a multitude of natural products, including alkaloids found in plants, fungi, insects, marine ...
Carl Bowman +2 more
wiley +1 more source