Results 171 to 180 of about 856,070 (259)

Isoquercitrin Alleviates Diabetic Nephropathy by Inhibiting STAT3 Phosphorylation and Dimerization

Advanced Science, EarlyView.
This study identified a natural compound, isoquercitrin, which significantly alleviated kidney inflammation and fibrosis by inhibiting STAT3 activity. Isoquercitrin forms a strong, noncovalent bond that directly binds to STAT3. Isoquercitrin binds to the pY+1 pocket of the SH2 domain of STAT3 via hydrogen bonding with Ser668, Gln635, and Gln633 ...
Chen Xuan, Donghui Chen, Shuangna Zhang, Chaofan Li, Qingyun Fang, Dinghua Chen, Jiabao Liu, Xin Jiang, Yingjie Zhang, Wanjun Shen, Guangyan Cai, Xiangmei Chen, Ping Li   +12 more
wiley   +1 more source

Root fragment weight and carbohydrate dynamics of two weedy thistles <i>Cirsium arvense</i> (L.) Scop. and <i>Sonchus arvensis</i> L. during sprouting. [PDF]

PeerJ
Weigel MM, Andert S, Alt M, Weiß K, Müller J, Gerowitt B.   +5 more
europepmc   +1 more source

Identification of Tumor‐Specific Surface Proteins Enables Quantification of Extracellular Vesicle Subtypes for Early Detection of Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic ductal adenocarcinoma (PDAC) extracellular vesicle (EV) surface protein assay operates via a two‐step workflow – Step 1: Click chemistry‐mediated enrichment of PDAC EVs by EV Click Beads, in the presence of one of the three trans‐cyclooctene‐grafted PDAC EV‐specific antibodies; Step 2: Quantification of the enriched PDAC EVs by reverse ...
Chen Zhao, Zhili Wang, Hyoyong Kim, Hui Kong, Junseok Lee, Jacqueline Ziqian Yang, Anmin Wang, Ryan Y. Zhang, Yong Ju, Jina Kim, Bing Feng, Dejun Liu, Yating Zhang, Zhenfang Wang, Yandong Zhang, Shujing Guo, Dekang Gao, James S. Tomlinson, Renjun Pei, Jipeng Wan, Stephen J. Pandol, Myung‐Shin Sim, Sungyong You, Ding Ma, Shaohua Lu, Na Sun, Hsian‐Rong Tseng, Yazhen Zhu   +27 more
wiley   +1 more source

A Review of Carbohydrate Supplementation Approaches and Strategies for Optimizing Performance in Elite Long-Distance Endurance. [PDF]

Nutrients
Cao W, He Y, Fu R, Chen Y, Yu J, He Z.
europepmc   +1 more source

A Transition Metal‐Free Approach for the Conversion of Real‐Life Cellulose‐Based Biomass into Formate

Advanced Science, EarlyView.
A visible‐light‐mediated method has been developed for the direct conversion of biomass into formate at ambient temperature and atmospheric pressure. This approach achieves the selective generation of hydroxyl radicals, which subsequently transform sugars, cellulose, and hemicellulose into formate.
Tong Zhang, Peng Ren, Yuman Qin, Thanh Huyen Vuong, Ana V. Cunha, Remco W. A. Havenith, Jabor Rabeah, Shoubhik Das   +7 more
wiley   +1 more source

Benfotiamine, a Lipid-Soluble Derivative of Vitamin B₁, Ameliorates the Carbohydrate Overload-Induced Mitochondrial Dysfunction in Fish <i>Megalobrama amblycephala</i> by Triggering the ULK1-Mediated Mitophagy. [PDF]

Aquac Nutr
Zhang L, He C, Liu Z, Jiang G, Liu W, Zhang D, Li X.   +6 more
europepmc   +1 more source

Sugar Functionalized Collagen Material for Local Modulation of Innate Immunity

Advanced Science, EarlyView.
Modulation of the innate immune response at the implant site can significantly influence adaptive immunity. A mannose‐functionalized collagen patch, termed the Local Immunotuning Patch (LIP), has been designed to engage mannose receptors on antigen‐presenting cells while exhibiting antibacterial properties. LIP orchestrates complex immune pathways that
Francesca Taraballi, Claudia Corbo, Julia Enterria‐Rosales, John Otto Martinez, Silvia Minardi, Laura Pandolfi, Xing Wang, Ennio Tasciotti, Kavindra V. Singh, Cesar A. Arias, Bruna Corradetti   +10 more
wiley   +1 more source

Isolating the acute metabolic effects of carbohydrate restriction on postprandial metabolism with or without energy restriction: a crossover study. [PDF]

Eur J Nutr
Biyikoglu H, Robertson MD, Collins AL.
europepmc   +1 more source

High Sugar Induced RCC2 Lactylation Drives Breast Cancer Tumorigenicity Through Upregulating MAD2L1

Advanced Science, EarlyView.
This study finds that KAT2A mediates the lactylation modification of the non‐histone protein RCC2 at K124, facilitating the recruitment of free SERBP1 and aiding in the formation of the initial SERBP1‐MAD2L1 complex. SERBP1 enhances the stability of MAD2L1 mRNA and promotes cellular proliferation.
Bowen Zheng, Yunhao Pan, Fengyuan Qian, Diya Liu, Danrong Ye, Bolin Yu, Seng Zhong, Wenfang Zheng, Xuehui Wang, Baian Zhou, Yuying Wang, Lin Fang   +11 more
wiley   +1 more source

Caffeine Supplementation Is Beneficial for the Pulling Performance of Indoor Tug-of-War Athletes. [PDF]

Biology (Basel)
Lin CP, Lee TT, Li TL.
europepmc   +1 more source