Results 181 to 190 of about 469,183 (313)

On the Relentless Pursuit of an Oral Insulin Delivery System: How Far is Too Far?

open access: yesAdvanced Therapeutics, EarlyView.
Injectable insulin preparations have far outpaced oral ones by virtue of adequate bioavailability and are driven by innovations, including insulin pumps, real‐time blood glucose monitoring, and artificial intelligence. In contrast, oral insulin delivery systems, including nanomedicines, continue to struggle and lag due to varied reasons.
Sourav Bhattacharjee
wiley   +1 more source

Performance of Liquid Biopsy‐Based Multi‐Omics Biomarkers for Early Detection of Gynecological Malignancies: A Prospective Study (PERCEIVE‐I)

open access: yesAdvanced Science, EarlyView.
Following a comparative analysis of omics‐based cancer detection models, a novel liquid biopsy‐based multi‐omics combined model is developed for the early detection of gynecological malignancies. By integrating cell‐free DNA methylation and tumor protein markers, the combined model demonstrates high specificity and sensitivity and is uniquely designed ...
Zheng Feng   +17 more
wiley   +1 more source

Lycium barbarum Glycopeptide Alleviates Neomycin‐Induced Ototoxicity by Inhibiting Tryptophan Hydroxylase‐Mediated Serotonin Biosynthesis

open access: yesAdvanced Science, EarlyView.
Lycium barbarum glycopeptide (LBGP), which is further extracted from Lycium barbarum polysaccharides, exhibits significant protective effects against neomycin‐induced hearing dysfunction including oxidative stress in cochlea and loss of key cells in cochlea.
Yunhao Wu   +12 more
wiley   +1 more source

Structural Insights into an Antiparallel Chair‐Type G‐Quadruplex From the Intron of NOP56 Oncogene

open access: yesAdvanced Science, EarlyView.
This study first reports that the intron 1 of NOP56 oncogene forms an antiparallel chair‐type G4 structure composed of two G‐tetrads and one C∙G∙C∙G tetrad. NOP56 gene transcription can be inhibited by PDS that binds and stabilizes NOP56‐G4. Solution NMR structures of the free NOP56‐G4 and NOP56‐G4‐PDS complex provide valuable insights into G4 ...
Zhenzhen Yan   +11 more
wiley   +1 more source

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