Results 151 to 160 of about 262,922 (191)

Carbohydrate-active enzymes (CAZymes) in the gut microbiome

Nature Reviews Microbiology, 2022
The 1013-1014 microorganisms present in the human gut (collectively known as the human gut microbiota) dedicate substantial percentages of their genomes to the degradation and uptake of carbohydrates, indicating the importance of this class of molecules.
Jacob F. Wardman, Rajneesh K. Bains, Peter Rahfeld, Stephen G. Withers   +3 more
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Enzyme promiscuity of carbohydrate active enzymes and their applications in biocatalysis

Current Opinion in Structural Biology, 2020
The application of biocatalysis for the synthesis of glycans and glycoconjugates is a well-established and successful strategy, both for small and large scale synthesis. Compared to chemical synthesis, is has the advantage of high selectivity, but biocatalysis had been largely limited to natural glycans both in terms of reactivity and substrates.
Edward, Pallister, Christopher J, Gray, Sabine L, Flitsch   +2 more
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Building mutational bridges between carbohydrate-active enzymes

Current Opinion in Biotechnology, 2022
The commercial value of specialty carbohydrates and glycosylated compounds has sparked considerable interest in the synthetic potential of carbohydrate-active enzymes (CAZymes). Protein engineering methods have proven to be highly successful in expanding the range of glycosylation reactions that these enzymes can perform efficiently and cost ...
Jorick, Franceus, Jolien, Lormans, Tom, Desmet   +2 more
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Role of carbohydrate-active enzymes in mycorrhizal symbioses

Essays in Biochemistry, 2023
Abstract Mycorrhizal fungi form mutually beneficial interactions with a wide range of terrestrial plants. During this symbiosis, the associated fungus provides mineral nutrients, such as phosphorus and nitrogen, to its host plant in exchange of photosynthesis-derived carbohydrates.
Gong, Yuhua, Lebreton, Annie, Zhang, Feng, Martin, Francis   +3 more
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Carbohydrate-active enzymes: sequences, shapes, contortions and cells

Biochemical Society Transactions, 2016
The enzyme-catalysed degradation of oligo and polysaccharides is of considerable interest in many fields ranging from the fundamental–understanding the intrinsic chemical beauty–through to the applied, including diverse practical applications in medicine and biotechnology.
Gideon J, Davies, Spencer J, Williams
openaire   +2 more sources

Polymeric Iminosugars Improve the Activity of Carbohydrate-Processing Enzymes

Bioconjugate Chemistry, 2015
Multivalent iminosugars have recently emerged as powerful tools to inhibit the activities of specific glycosidases. In this work, biocompatible dextrans were coated with iminosugars to form linear and ramified polymers with unprecedently high valencies (from 20 to 900) to probe the evolution of the multivalent inhibition as a function of ligand valency.
Brissonnet, Yoan, Ladeveze, Simon, Teze, David, Fabre, Emeline, Deniaud, David, Daligault, Franck, Tellier, Charles, Sesták, Sergej, Remaud Simeon, Magali, Potocki-Veronese, Gabrielle, Gouin, Sébastien G   +10 more
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Synthetic Strategies for FRET-Enabled Carbohydrate Active Enzyme Probes

2021
Carbohydrates are an essential class of biomolecule and carbohydrate active enzymes (CAZys) catalyze their synthesis, refinement, and degradation, hence contributing an overall regulatory capacity to their underpinning physiological roles. Here we survey recent accomplishments for accessing defined carbohydrate structures, suitably equipped with FRET ...
Singh, Meenakshi, Watkinson, Michael, Scanlan, Eoin M., Miller, Gavin J.   +3 more
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Electrostatic studies of carbohydrate active enzymes

1995
Abstract Most charged or titratable residues reside on the protein surface. Each of such residues will exhibit a titration behaviour that is dependent on the local context around the residue. As a consequence both pH, salt and docking of a ligand into the binding cavity of a protein can be expected to alter the protein electrostatics.
Antonio Baptista, Trygve Brautaset, Finn Drabløs, Paulo Martel, Svein Valla, Steffen B. Petersen   +5 more
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Exploring the sheep rumen microbiome for carbohydrate-active enzymes

Antonie van Leeuwenhoek, 2015
The rumen is a complex ecosystem enriched for microorganisms able to degrade biomass during the animal's digestion process. The recovery of new enzymes from naturally evolved biomass-degrading microbial communities is a promising strategy to overcome the inefficient enzymatic plant destruction in industrial production of biofuels. In this context, this
Lucas Dantas, Lopes, André Oliveira, de Souza Lima, Rodrigo Gouvêa, Taketani, Phillip, Darias, Lília Raquel Fé, da Silva, Emiliana Manesco, Romagnoli, Helder, Louvandini, Adibe Luiz, Abdalla, Rodrigo, Mendes   +8 more
openaire   +2 more sources