Results 121 to 130 of about 194,368 (169)
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Nature Methods, 2017
A technique combining mass spectrometry and infrared spectroscopy shows promise for unambiguous sequencing of linear oligosaccharides.
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A technique combining mass spectrometry and infrared spectroscopy shows promise for unambiguous sequencing of linear oligosaccharides.
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LINUCS: LInear Notation for Unique description of Carbohydrate Sequences
Carbohydrate Research, 2001The use of proteomics databases has become indispensable for daily work of molecular biologists, but this situation has not yet been achieved for carbohydrate applications. One obvious reason is that existing data collections are only rarely annotated and no cross-linking to other resources exists.
A, Bohne-Lang +3 more
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Hybrid method sequences carbohydrates
C&EN Global Enterprise, 2017Methods for routine sequencing of carbohydrates lag behind those for sequencing nucleic acids and proteins. The lack of such methods makes fully characterizing carbohydrates difficult. Sequencing a carbohydrate is a challenge because many of the sugar building blocks are isomers of one another, making it hard to distinguish between them, and the ...
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Carbohydrate-active enzymes: sequences, shapes, contortions and cells
Biochemical Society Transactions, 2016The enzyme-catalysed degradation of oligo and polysaccharides is of considerable interest in many fields ranging from the fundamental–understanding the intrinsic chemical beauty–through to the applied, including diverse practical applications in medicine and biotechnology.
Gideon J, Davies, Spencer J, Williams
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Fluorosugar Chain Termination Agents as Probes of the Sequence Specificity of a Carbohydrate Polymerase [PDF]
Journal of the American Chemical Society, 2012 Naturally occurring carbohydrate polymers are ubiquitous. They are assembled by polymerizing glycosyltransferases, which can generate polysaccharide products with repeating sequence patterns. The fidelity of enzymes of this class is unknown. We report a method for testing the fidelity of carbohydrate polymerase pattern deposition: we synthesized ...
Laura L Kiessling
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Carbohydrate sequences detected by murine monoclonal antibodies
Chemistry and Physics of Lipids, 1986The carbohydrate sequences of cell surface glycolipids change during differentiation and oncogenic transformation. To detect these structural changes, murine monoclonal antibodies have been produced in many different laboratories. Some of these antibodies are used to distinguish various cell types such as normal and transformed cells, while others are ...
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Sequence-Specific Peptide−Carbohydrate Interactions in an Asparagine-Linked Glycopeptide
The Journal of Organic Chemistry, 1996Asparagine glycosylation (N-glycosylation) of the AsnXaa-Ser/Thr sequence is a cotranslational process that can affect protein structure and function.1,2 Little is known, however, about glycosylation’s influence on the structure of flexible N-glycopeptides.3-7 Fluorescence studies show that N-glycosylation can alter peptide backbone conformation.6 ...
Kwun-Chi, Lee +2 more
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Sequencing methods for carbohydrates and their biological applications
Trends in Biotechnology, 1989Abstract The diversity of oligosaccharide structures may confer the specificity inherent in many molecular and cellular interactions. Scientists from numerous disciplines are faced with the challenge of determining their sequence and deciphering their function.
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Biological Mass Spectrometry, 1974
Mass spectrometry has been applied for a detailed structural characterization of glycosphingolipids. Methylated and methylated plus reduced glycolipids (amide groups of ceramide and amino sugars were reduced to the corresponding amines) were found the most useful derivatives.
K A, Karlsson +3 more
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Mass spectrometry has been applied for a detailed structural characterization of glycosphingolipids. Methylated and methylated plus reduced glycolipids (amide groups of ceramide and amino sugars were reduced to the corresponding amines) were found the most useful derivatives.
K A, Karlsson +3 more
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CabosDB: Carbohydrate Sequencing Database
2009High-throughput methods for sequencing biomolecules such as DNA, RNA and proteins, and for profiling their patterns of expression have accelerated genome-wide analyses in living organisms. Further, they have enabled molecular biologists and biochemists to investigate biological functions and disorders, the so-called -omics studies. Glycomics, which has
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