Results 161 to 170 of about 1,925,168 (307)

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

Novel Azole-Tethered Carbohydrate Dimers

This paper describes synthesis and biological activity of various novel carbohydrate-azole ...
Lugiņina, Jevgeņija, Mackeviča, Jevgeņija, Beļakovs, Sergejs, Moreno Vargas, Antonio José, Robina, Inmaculada, Turks, Māris, Rjabovs, Vitālijs   +6 more
core  

Selected patent applications in carbohydrate sequencing [PDF]

Nature Biotechnology, 1998
openaire   +1 more source

Exploring the effect of tandem non-native non-F-type lectin carbohydrate-binding domains on <i>Streptosporangium roseum</i> α-L-Fucosidase activity. [PDF]

Biochem Biophys Rep
Shivangi, Lata M, Subramanian S, Ramya TNC.   +3 more
europepmc   +1 more source

Single‐Cell Transcriptomics and Metabolomics Reveal Glutamate Dehydrogenase as a Central Regulator of Nitrogen Metabolic Remodeling During Alkalinity Adaptation in Crustaceans

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals the cellular response of Macrobrachium hainanense to carbonate alkalinity stress. Alkalinity stress impairs branchial ammonia excretion, induces mitochondrial dysfunction, and drives cell‐type‐specific changes in gills and hemocytes.
Yiting Jin, Zhimin Lv, Chao Bian, Qibin Yang, Na Zhou, Jianguang Qin, Shengming Sun   +6 more
wiley   +1 more source

Access to unnatural oligosaccharides under mild glycosidation conditions

, 2011
Herein, we report a new strategy for the synthesis of oligosaccharides containing enantiopure L-hexoses. Key for the success of this approach is the use of alfa-L- and beta-L-sugar derivatives, whose preparation through a “domino” reaction starting from ...
GUARAGNA, ANNALISA, PALUMBO, GIOVANNI, D'ALONZO, DANIELE, Dell’Isola A.   +3 more
core  

Whole genome sequence data of a cellulose degrading bacterium, Bacillus sp. ABR isolated from the soils of Kurseong, India. [PDF]

Data Brief
Show BK, Lodha T, Ghosh A, Dhakephalkar P, Ross AB, Chaudhury S, Balachandran S.   +6 more
europepmc   +1 more source

A pH‐Switchable Cerium Single‐Atom Enzyme for Peri‐Implantitis Therapy via JAK‐STAT Signaling Axis‐Mediated Macrophage Reprogramming

Advanced Science, EarlyView.
A pH‐switchable cerium single‐atom enzyme is developed for stage‐specific peri‐implantitis therapy. Acidic conditions trigger antibacterial peroxidase‐like activity, whereas neutral conditions activate an antioxidant superoxide dismutase ‐ and catalase ‐like enzymatic relay. This microenvironment‐adaptive catalytic strategy suppresses the IL‐6/JAK‐STAT
Xiaomin Xia, Haojie Wu, Xingyun Li, Lining Liu, Kaiqing Song, Jinpei Cui, Jie Liu, Jiaxuan Yin, Emtiaz Ahmed, Yusuke Yamauchi, Xue Li   +10 more
wiley   +1 more source

Colorectal laterally spreading tumors exhibit a distinct carcinogenic eco-metabolic shift defined by multi-omics profiling. [PDF]

Front Microbiol
Liu W, Liu J, Chen Y, Lu G, Shen J, Zheng X, Wei X.   +6 more
europepmc   +1 more source

A C‐Nucleoside Analogue of Cordycepin With High Metabolic Stability and Potent Anti‐Psoriatic Activity via Microneedle Delivery

Advanced Science, EarlyView.
This work identified CPD3a as a potent, stable C‐nucleoside cordycepin derivative. When formulated into microneedle array for topical treatment, it ameliorated psoriasis by rebalancing immunity and enhancing antioxidant defenses. ABSTRACT Psoriasis is a chronic inflammatory disorder characterized by immune dysregulation and epidermal hyperplasia ...
Wenfang Pan, Xinyue Shao, Yuanchen Zhong, Xujie Sun, Lixuan Yin, Zongyan He, Tianqun Lang, Yuanchao Xie   +7 more
wiley   +1 more source