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Comprehensive Literature Review of Hyperpolarized Carbon-13 MRI: The Road to Clinical Application [PDF]

open access: yesMetabolites, 2021
This review provides a comprehensive assessment of the development of hyperpolarized (HP) carbon-13 metabolic MRI from the early days to the present with a focus on clinical applications.
Michael Vaeggemose   +2 more
doaj   +2 more sources

MRI Application and Challenges of Hyperpolarized Carbon-13 Pyruvate in Translational and Clinical Cardiovascular Studies: A Literature Review [PDF]

open access: yesDiagnostics
Cardiovascular disease shows, or may even be caused by, changes in metabolism. Hyperpolarized magnetic resonance spectroscopy and imaging is a technique that could assess the role of different aspects of metabolism in heart disease, allowing real-time ...
Francesca Frijia   +6 more
doaj   +2 more sources

Hyperpolarized Carbon-13 MRI in Breast Cancer

open access: yesDiagnostics, 2023
One of the hallmarks of cancer is metabolic reprogramming, including high levels of aerobic glycolysis (the Warburg effect). Pyruvate is a product of glucose metabolism, and 13C-MR imaging of the metabolism of hyperpolarized (HP) [1-13C]pyruvate (HP 13C ...
Ramona Woitek, Kevin M. Brindle
doaj   +1 more source

Efficient SABRE-SHEATH Hyperpolarization of Potent Branched-Chain-Amino-Acid Metabolic Probe [1-13C]ketoisocaproate

open access: yesMetabolites, 2023
Efficient 13C hyperpolarization of ketoisocaproate is demonstrated in natural isotopic abundance and [1-13C]enriched forms via SABRE-SHEATH (Signal Amplification By Reversible Exchange in SHield Enables Alignment Transfer to Heteronuclei).
Isaiah Adelabu   +9 more
doaj   +1 more source

Multivariate analysis of stable isotope data in the traceability process for birds=Análise multivariada em dados de isótopos estáveis no processo de rastreabilidade em aves [PDF]

open access: yesActa Scientiarum: Animal Sciences, 2012
Isotope analysis has proved to be an extremely important tool in the traceability process; however, statistical analyses of the results show discrepancies, as the data depend on and originate from several chemical elements such as carbon, hydrogen ...
Maria Márcia Pereira Sartori   +4 more
doaj   +1 more source

Elucidation of Lignin and Polysaccharide Linkages in Wheat Straw by 2H/13C Isotopic Tracer

open access: yesBioResources, 2022
To elucidate chemical linkages between lignin and polysaccharides, the aqueous mixed solutions of coniferin-[α-13C], syringin-[α-13C], D-glucose-[6-2H], and phenylalanine ammonia-lyase inhibitor were injected into a living wheat stalk.
Yimin Xie   +4 more
doaj   +2 more sources

Effect of rearing conditions on fatty acid allocation during flight in nectivorous lepidopteran Mythimna unipuncta

open access: yesFrontiers in Ecology and Evolution, 2023
Insect species that are nectivorous as adults acquire essential fatty acids almost exclusively from host plants during larval development. Thus, as essential fatty acids are important for a number of different biological processes, adult allocation of ...
Libesha Anparasan   +3 more
doaj   +1 more source

Inhibiting Glycine Decarboxylase Suppresses Pyruvate-to-Lactate Metabolism in Lung Cancer Cells

open access: yesFrontiers in Oncology, 2018
Glycine decarboxylase (GLDC) gene is frequently upregulated in various types of cancer including lung, prostate and brain. It catabolizes glycine to yield 5,10-methylenetetrahydrofolate, an important substrate in one-carbon metabolism for nucleotide ...
Chern Chiuh Woo   +4 more
doaj   +1 more source

Isotopic (δ2H) Analysis of Stored Lipids in Migratory and Overwintering Monarch Butterflies (Danaus plexippus): Evidence for Southern Critical Late-Stage Nectaring Sites?

open access: yesFrontiers in Ecology and Evolution, 2020
Monarch butterflies (Danaus plexippus) fuel their migration and overwinter energy needs through accumulated fat stores derived from plant nectars. Determining origins of these fuels is crucial to effective conservation programs.
Keith A. Hobson   +8 more
doaj   +1 more source

Hyperpolarized 13C Magnetic Resonance Spectroscopic Imaging of Pyruvate Metabolism in Murine Breast Cancer Models of Different Metastatic Potential

open access: yesMetabolites, 2021
This study uses dynamic hyperpolarized [1-13C]pyruvate magnetic resonance spectroscopic imaging (MRSI) to estimate differences in glycolytic metabolism between highly metastatic (4T1, n = 7) and metastatically dormant (4T07, n = 7) murine breast cancer ...
Erin B. Macdonald   +9 more
doaj   +1 more source

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