Results 21 to 30 of about 2,389,522 (251)
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Carbon Dioxide Production in Animal Houses: A literature review [PDF]
, 2008 This article deals with carbon dioxide production from farm animals; more specifically, it addresses the possibilities of using the measured carbon dioxide concentration in animal houses as basis for estimation of ventilation flow (as the ventilation ...
Chwalibog, A. +9 more
core
, 2021 This book focuses on carbon dioxide and its global role in our everyday life. Starting with society's dependency on energy, it demonstrates the various sources of carbon dioxide and discusses the putative effects of its accumulation in the atmosphere and
Michele Aresta, Angela Dibenedetto
core +1 more source
FEBS Open Bio, EarlyView.NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti +5 more
wiley +1 more source
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
The Role of Carbon Dioxide in Host-Finding by Mosquitoes (Diptera: Culicidae): A Review [PDF]
, 1980 \ud From a critical review of the literature, it is concluded that the role of carbon dioxide in host-seeking by mosquitoes comprises two distinct actions.
Gillies, M.T.
core
Facial Cosmetic Therapy Use Among Patients With Systemic Sclerosis: An Australian Cohort Study
Arthritis Care &Research, EarlyView.Objective Systemic sclerosis (SSc) is associated with numerous facial manifestations for which patients may engage in cosmetic therapies. It is unclear how patients with SSc use these therapies. This study sought to characterize patient engagement and experiences with cosmetic therapies for SSc‐related and non‐SSc–related facial changes.
Zachary Warren +11 more
wiley +1 more source
Mean and Flux Horizontal Variability of Virtual Potential Temperature, Moisture, and Carbon Dioxide: Aircraft Observations and LES Study [PDF]
, 2008 The effects of the horizontal variability of surface properties on the turbulent fluxes of virtual potential temperature, moisture, and carbon dioxide are investigated by combining aircraft observations with large-eddy simulations (LESs).
Górska, M. +3 more
core +1 more source