Results 141 to 150 of about 248,468 (218)

PROTAC: a revolutionary technology propelling small molecule drugs into the next golden age. [PDF]

Front Oncol
Cai J, Chen C, Wang J, Zhang X, Cui Y, Zhu Q, Sun H.   +6 more
europepmc   +1 more source

DNA methyltransferase inhibitors in hematological malignancies and solid tumors

International Journal of Cancer, Volume 158, Issue 2, Page 433-461, 15 January 2026.
Abstract Epigenetic modifications such as DNA methylation play a fundamental role in oncogenesis and the progression of neoplasms neoplasias. DNA methyltransferase inhibitors (DNMTi) constitute a family of therapeutic agents that impede the methylation at the 5‐position on cytosine nucleotides, thereby modulating the epigenetic regulation of tumor ...
Valentin Wenger, Guillermo Garcia‐Manero, Robert Zeiser, Michael Lübbert   +3 more
wiley   +1 more source

The puzzle of two tandem acyl-CoA ligases of <i>Pseudomonas putida</i> F1. [PDF]

Appl Environ Microbiol
Dong H, Chen B, Wang H, Cronan JE.
europepmc   +1 more source

Secondary metabolism of <i>Microcystis</i>: current understanding and recent advances in unlocking genomic and chemical diversity. [PDF]

Appl Environ Microbiol
Yancey CE, Hart LN, Dick GJ.
europepmc   +1 more source

Development of a targeted BioPROTAC degrader selective for misfolded SOD1. [PDF]

Nat Commun
Chisholm CG, Bartlett R, Brown ML, Proctor EJ, Farrawell NE, Gorman J, Delerue F, Ittner LM, Vine-Perrow KL, Ecroyd H, Cashman NR, Saunders DN, McAlary L, Lum JS, Yerbury JJ.   +14 more
europepmc   +1 more source

STING-targeting PROTACs: emerging therapeutic tools for enhanced immunotherapy in inflammatory diseases. [PDF]

Front Immunol
Jiang W, Yang X, Liu H, Wang C, Niu H, Yu W.   +5 more
europepmc   +1 more source

Proteomic insights into the physiology and metabolism of oleaginous yeasts and filamentous fungi. [PDF]

Front Microbiol
Gluth A, Trejo JB, Czaijka JJ, Deng S, Qian WJ, Yang B, Zhang T.   +6 more
europepmc   +1 more source

Vincristine impairs musculoskeletal development in pediatric mice. [PDF]

BMC Cancer
Jamnick NA, Livingston PD, Gammon CJ, Weinzierl NM, Novinger LJ, Adams DJ, Bonetto A.   +6 more
europepmc   +1 more source

Nitrogen-Driven Orchestration of Lateral Root Development: Molecular Mechanisms and Systemic Integration. [PDF]

Biology (Basel)
Sun X, Gu Y, Liu Y, Liu Z, Wang P.
europepmc   +1 more source

The HECT ubiquitin-protein ligases UPL1 and UPL2 are involved in degradation of Arabidopsis thaliana ACC synthase 7. [PDF]

Physiol Plant
Marczak M, Cieśla A, Janicki M, Mehdi SMM, Kubiak P, Ludwików A.   +5 more
europepmc   +1 more source