Results 71 to 80 of about 3,037,528 (395)

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

FEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source

Interaction of class III cellobiose dehydrogenase with lytic polysaccharide monooxygenase

FEBS Open Bio, EarlyView.
The activity of lytic polysaccharide monooxygenase (LPMO) is supported by its auxiliary enzyme cellobiose dehydrogenase (CDH). The catalytic activity of both enzymes is coupled by electron transfer and a cyclic cascade generating substrates for both enzymes – hydrogen peroxide for LPMO and oxidized and non‐oxidized cellobiose and cello‐oligosaccharide ...
Angela Giorgianni, Florian Csarman, Peicheng Sun, Mirjam Kabel, Roland Ludwig   +4 more
wiley   +1 more source

Estimating carbon fixation of plant organs for afforestation monitoring using a process‐based ecosystem model and ecophysiological parameter optimization

Ecology and Evolution, 2019
Afforestation projects for mitigating CO2 emissions require to monitor the carbon fixation and plant growth as key indicators. We proposed a monitoring method for predicting carbon fixation in afforestation projects, combining a process‐based ecosystem ...
Tatsuya Miyauchi, Takashi Machimura, Makoto Saito   +2 more
doaj   +1 more source

Solar-driven carbon dioxide fixation using photosynthetic semiconductor bio-hybrids. [PDF]

, 2019
Solar-driven conversion of carbon dioxide to value-added carbon products is an ambitious objective of ongoing research efforts. However, high overpotential, low selectivity and poor CO2 mass transfer plague purely inorganic electrocatalysts.
Cestellos-Blanco, Stefano, Yang, Peidong, Zhang, Hao   +2 more
core   +1 more source

Modeling pN2 through Geological Time: Implications for Planetary Climates and Atmospheric Biosignatures [PDF]

, 2016
Nitrogen is a major nutrient for all life on Earth and could plausibly play a similar role in extraterrestrial biospheres. The major reservoir of nitrogen at Earth's surface is atmospheric N2, but recent studies have proposed that the size of this ...
Buick, R., Johnson, B., Kipp, M. A., Koehler, M. C., Schwieterman, E. W., Stüeken, E. E.   +5 more
core   +2 more sources

RhoA and Rac1 as Mechanotransduction Mediators in Colorectal Cancer

Advanced Biology, EarlyView.
Analysing RhoA and Rac1 protein levels in Colorectal cancer (CRC) samples under mechanical strain highlights their potential as diagnostic markers. Monitoring their activity could offer valuable insights into how cancer spreads, paving the way for new approaches to better understand and diagnose colorectal cancer.
Sharda Yadav, Sanjaya KC, Mark A. T. Blaskovich, Cu‐tai Lu, Alfred K Lam, Nam‐Trung Nguyen   +5 more
wiley   +1 more source

Biomass Production and Carbon Sequestration by Cultivation of Trees under Hyperarid Conditions using Desalinated Seawater (Sewage Water) [PDF]

, 2019
As growing economies – in particular in the Gulf region – use extreme and growing amounts of desalinated seawater for municipal purposes the use of produced waste waters is in the focus of science.
Becker, Klaus, Ohlde, Gerhard W., Stadtlander, Timo   +2 more
core   +1 more source

Chloroplasts— Beyond Energy Capture and Carbon Fixation: Tuning of Photosynthesis in Response to Chilling Stress

International Journal of Molecular Sciences, 2019
As organelles for photosynthesis in green plants, chloroplasts play a vital role in solar energy capture and carbon fixation. The maintenance of normal chloroplast physiological functions is essential for plant growth and development.
Ping Gan, Fang Liu, Rong-bai Li, Shaokui Wang, Jijing Luo   +4 more
semanticscholar   +1 more source

Investigating the Cellular Effects of GALC Dosing in Enzyme Replacement Therapy for Krabbe Disease Supports the Role of Nanomedicine

Advanced Biology, EarlyView.
A detailed workflow for recombinant GALC production and characterization is presented to support enzyme replacement therapy for Krabbe disease. In vitro assays demonstrate that physiological GALC doses restore enzymatic activity and autophagic flux without affecting cell viability, whereas higher doses impair autophagy and reduce viability.
Ambra Del Grosso, Sara Carpi, Laura Colagiorgio, Miriam De Sarlo, Mariacristina Gagliardi, Marco Cecchini   +5 more
wiley   +1 more source