Results 181 to 190 of about 23,949 (213)

Nickel-Containing Carbon Monoxide Dehydrogenase/Acetyl-CoA Synthase^,

Chemical Reviews, 1996
This article reviews an enzyme with two important catalytic activities, carbon monoxide dehydrogenase (CODH) (reaction 1) and acetyl-CoA synthase (ACS) (reaction 2). These reactions are key to an autotrophic pathway that has become known as the reductive acetyl-CoA or the Wood/Ljungdahl pathway.
Stephen W., Ragsdale, Manoj, Kumar
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Anaerobic Carbon Monoxide Dehydrogenase

1996
Ten years ago, the scheme describing CO2 fixation by the acetyl-CoA pathway was significantly changed (Ragsdale, Wood, 1985). The key enzyme in the pathway was proposed to be carbon monoxide dehydrogenase (CODH) and this enzyme, not a B12 enzyme, was proposed to bind, activate, and condense the methyl, carbonyl, and CoA groups to form acetyl-CoA.
S. W. Ragsdale, M. Kumar, J. Seravalli, D. Qiu, T. G. Spiro   +4 more
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Carbon Monoxide. Toxic Gas and Fuel for Anaerobes and Aerobes: Carbon Monoxide Dehydrogenases

2014
Carbon monoxide (CO) pollutes the atmosphere and is toxic for respiring organisms including man. But CO is also an energy and carbon source for phylogenetically diverse microbes living under aerobic and anaerobic conditions. Use of CO as metabolic fuel for microbes relies on enzymes like carbon monoxide dehydrogenase (CODH) and acetyl-CoA synthase (ACS)
Jae-Hun, Jeoung, Jochen, Fesseler, Sebastian, Goetzl, Holger, Dobbek   +3 more
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Infrared Studies of Carbon Monoxide Binding to Carbon Monoxide Dehydrogenase/Acetyl-CoA Synthase fromMoorella thermoacetica

Biochemistry, 2003
Carbon monoxide dehydrogenase/acetyl-CoA synthase (CODH/ACS) is a bifunctional enzyme that catalyzes the reversible reduction of carbon dioxide into carbon monoxide and the coupled synthesis of acetyl-CoA from the carbon monoxide produced. Exposure of CODH/ACS from Moorella thermoacetica to carbon monoxide gives rise to several infrared bands in the ...
Jingyi, Chen, Shan, Huang, Javier, Seravalli, Howard, Gutzman, Derrick J, Swartz, Stephen W, Ragsdale, Kimberly A, Bagley   +6 more
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Inactivation of Acetyl-CoA Synthase/Carbon Monoxide Dehydrogenase by Copper

Journal of the American Chemical Society, 2003
Two recent crystal structures of acetyl-CoA synthase (ACS) from Moorella thermoacetica exhibited different metal contents and geometries at their active site, called the A-cluster. This led to the proposal of two catalytic mechanisms, one Ni-based, the other Cu-based.
Matthew R, Bramlett, Xiangshi, Tan, Paul A, Lindahl   +2 more
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Energetics for the Mechanism of Nickel-Containing Carbon Monoxide Dehydrogenase

Inorganic Chemistry, 2019
Nickel-containing carbon monoxide (CO) dehydrogenase is an enzyme that catalyzes the important reversible carbon dioxide reduction. Several high-resolution structures have been determined at various stages of the reduction, which can be used as good starting points for the present computational study.
Rong-Zhen Liao, Per E. M. Siegbahn
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Nickel-Carbon Bonds in Acetyl-Coenzyme A Synthases/Carbon Monoxide Dehydrogenases

2009
Acetyl-coenzyme A synthases/carbon monoxide dehydrogenases are bifunctional enzymes that catalyze the synthesis of acetyl-CoA and the reversible reduction of CO2 to CO. The active site for the first reaction, called the A-cluster, consists of a [Fe4S4] cubane bridged to a dinuclear nickel subcomponent.
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Carbon Dioxide Activation at the Ni,Fe-Cluster of Anaerobic Carbon Monoxide Dehydrogenase

Science, 2007
Anaerobic CO dehydrogenases catalyze the reversible oxidation of CO to CO 2 at a complex Ni-, Fe-, and S-containing metal center called cluster C. We report crystal structures of CO dehydrogenase II from Carboxydothermus hydrogenoformans in three ...
Jae-Hun, Jeoung, Holger, Dobbek
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Azide Binding to Carbon Monoxide Dehydrogenase from Clostridium thermoaceticum

Journal of the American Chemical Society, 1995
Carbon monoxide dehydrogenase (CODH) plays a central role in a recently discovered pathway of anaerobic CO and CO{sub 2} fixation. In this communication, the EPR properties of a paramagnetic species that results from azide treatment of reduced CODH are explored.
Manoj Kumar, Wei-Ping Lu, Alyssa Smith, Stephen W. Ragsdale, John McCracken   +4 more
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Mechanism of Ni,Fe-Containing Carbon Monoxide Dehydrogenases

2018
Carbon monoxide dehydrogenases catalyze the reversible oxidation of CO with water to CO2, two protons and two electrons. Phylogenetically diverse bacteria and archaea living under anaerobic conditions employ different classes of Ni,Fe-containing carbon monoxide dehydrogenases to use CO as an energy source or to contribute in converting CO2 to acetyl ...
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