Results 61 to 70 of about 467,094 (309)

Trade-offs/synergistic relationship between water ecosystem services and urbanization in the Yellow River Basin urban agglomeration [PDF]

Ziyuan Kexue
[Objective] The relationship between water ecosystem services and urbanization is related to regional sustainable development. The Yellow River Basin has pronounced water ecological problems, and clarifying the synergistic relationship between water ...
WAN Shilong, YANG Hainan, MA Li, YE Lufeng, ZHANG Zilong
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Research on Environmental Governance, Local Government Competition, and Agricultural Carbon Emissions under the Goal of Carbon Peak

, 2022
By introducing network game theory, this paper analyzes the internal relationship and interaction mechanism among environmental governance, local government competition, and agricultural carbon peak level.
Yun Tian, Xuhui Peng, Minhao Yin, Yingya Yang, Haiwen Yang, Wei Wang   +5 more
core   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Shell-Optimized Hybrid Generator for Ocean Wave Energy Harvesting

Energies
With the increasing global emphasis on sustainable energy, wave energy has gained recognition as a significant renewable marine resource, drawing substantial research attention.
Heng Liu, Dongxin Guo, Hengda Zhu, Honggui Wen, Jiawei Li, Lingyu Wan   +5 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Residential peak electricity demand response—Highlights of some behavioural issues

, 2013
Electricity demand response refers to consumer actions that change the utility load profile in a way that reduces costs or improves grid security. The focus of demand response has mainly been on the commercial and big industrial sectors because of the ...
Krumdieck, S., Krumdieck, Susan; id_orcid, Gyamfi, S., Urmee, Tania, Urmee, T., Gyamfi, Samuel   +5 more
core   +1 more source

Prediction of carbon peak in Beijing-Tianjin-Hebei Region based on STIRPAT model

, 2023
In order to solve the problem of early peak of carbon emissions the Beijing-Tianjin-Hebei Region，taking Hebei Province as an example, the realization path of peaking carbon emissions in the region was studied, and the future carbon emissions in the ...
Wei ZHAO, Zilin CAO, Yang YANG, Ligai KANG, Xiaoxue YUAN, Xiaojing WU, Wei LIU, Wenjing WANG   +7 more
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

The Impact of Unconventional Monetary Policy on China’s Economic and Financial Cycle: Application of a Structural Vector Autoregression Model Based on High-Frequency Data

Mathematics
With the occurrence of the global financial crisis in 2008, the U.S. unconventional monetary policy affected the Chinese market. Based on a monthly data sample from 2008M1 to 2015M12, in this paper we identify U.S.
Zhenzhong Fan, Xing Chen
doaj   +1 more source