Discovery of a Potent Fluorescence Polarization Probe for Identifying USP1 Allosteric Inhibitors
This study presents the first ubiquitin‐specific protease 1 (USP1) allosteric fluoroprobe and fluorescence polarization assay, enabling the differentiation of allosteric and catalytic site inhibitors. Further, a novel class of tetrahydroisoquinoline‐based USP1 inhibitors is designed, with compound 14a (USP1 IC50 = 29.9 nM) showing strong selectivity ...
Jiawei Cheng +12 more
wiley +1 more source
Mapping forest cover change and estimating carbon stock using satellite-derived vegetation indices in Alemsaga forest, Ethiopia. [PDF]
Tigabu A, Gessesse AA.
europepmc +1 more source
Mechanosensitive Piezo1/Osteocalcin/Irisin Axis Protects Against Disuse‐Induced Muscle Atrophy
Mechanical unloading suppresses bone Piezo1 expression, which reduces circulating undercarboxylated osteocalcin (unOCN). unOCN reduction subsequently exacerbates IMM‐induced Fndc5/Irisin decrease and drives severe muscle atrophy. Bone Piezo1 activation or exogenous osteocalcin/Irisin ameliorate muscle atrophy, while muscle‐specific Gprc6a or Fndc5 ...
Zhaolu Wang +5 more
wiley +1 more source
Full-Tree Biomass, Root Carbon Stock, and Nutrient Use Efficiency Across Ages in <i>Eucalyptus</i> Stands Under Seedling and Coppice Systems. [PDF]
de Oliveira GG +5 more
europepmc +1 more source
Through a systematic and comprehensive analysis of the environmental impacts for the emerging MXene synthesis pathways, this study presents process transformation and optimization opportunities for low‐carbon MXene production from laboratory to industrial scales.
Yushuai Huang +6 more
wiley +1 more source
Tree-based attributes of large trees more effectively regulate aboveground carbon stock than trait-based ones in temperate deciduous forests. [PDF]
Kazempour Larsary M +4 more
europepmc +1 more source
Precision Lignocellulosic Biorefinery: Process Regulation From Corn Stover to Products
This study presents a precision biorefinery framework that transforms corn stover into high‐value bioproducts through whole‐process regulation. Mechanical fractionation separates feedstock into parenchyma‐rich short fibers and vascular‐bundle‐dominant long fibers.
Xue‐Cheng Lin +4 more
wiley +1 more source
Assessment of Soil Carbon Stock and Soil Quality in Different Forest Stands and Management Regimes in Terai Region of Nepal. [PDF]
Kandel D +6 more
europepmc +1 more source
A diluent‐free, customizable liquid–liquid phase separation (LLPS) platform enables highly efficient radioactive metal ion extraction and stripping. By encapsulating hydrophobic extractants into an ionic surfactant‐rich condensed phase, this LLPS system leverages synergistic electrostatic and coordination interactions.
Ruihan Yan +7 more
wiley +1 more source
Wood density can best predict carbon stock in the forest aboveground biomass following restoration in a post open limestone mining in a tropical region. [PDF]
Mao J +7 more
europepmc +1 more source

