Protective Effect and Mechanism of Rosiglitazone in α-amanitin-induced Hepatotoxicity Via Activation of PPAR-γ/Nrf2 Signaling Pathway. [PDF]
J Biochem Mol ToxicolABSTRACT α‐amanitin (α‐AMA), the primary lethal toxin of amanita, primarily targets the liver with a high toxicity and a low lethal dose. As the precise mechanism of intoxication is unclear, and specific antidotes are lacking, α‐AMA‐induced liver injury has a high mortality rate.
Lai F +8 more
europepmc +2 more sources
HEPATOPROTECTIVE ACTION OF BIOPREPARATIONS FROM DEFATTED SOY AND SUNFLOWER LECITHINS [PDF]
Biotechnologia Acta, 2014 The results of studies of hepatoprotective activity of biopreparations of defatted soy and sunflower lecithins under carbon tetrachloride intoxication of the experimental animals are given.
Drozdov O. L. +3 more
doaj +1 more source
Inducible T-Cell Costimulator Mediates Lymphocyte/Macrophage Interactions During Liver Repair
Frontiers in Immunology, 2021 The liver capacity to recover from acute liver injury is a critical factor in the development of acute liver failure (ALF) caused by viral infections, ischemia/reperfusion or drug toxicity.
Naresh Naik Ramavath +8 more
doaj +1 more source
Open Medicine, 2022 N,N-Dimethylformamide (DMF) is widely used in chemical industries because of its excellent solvent properties. Poisoning accidents caused by DMF have been frequently reported, particularly hepatotoxicity; however, the hepatic pathological changes have ...
Wu Haicong +7 more
doaj +1 more source
Morphology of mitochondria and cell respiration,pt.1. [PDF]
, 1960 To reveal the mechanism of liver damage by taking CCl4 the author observed the liver tissues from rats at 1.5, 5, 6, 10, 17, 20, and 22 hours after the CCl4 administration, both by light microscope and electron-microscope. 1. Light microscope observation
Haba, Kyoichi
core +3 more sources
Influence of lecithins on disorders of cognitive functions of animals caused by tetrachloromethane.
Medičnì Perspektivi, 2020 In our time the study of the influence of soya and especially sunflower lecithin as one of the natural monopolies inUkraine, on the state of cognitive functions is relevant.
I. S. Svirgun +3 more
doaj +1 more source
Inflammation and Regeneration, 2022 Background Different factors may lead to hepatitis. Among which are liver inflammation and poisoning. We chose two hepatitis models, typical for these two underlying causes.
Gal Reches +10 more
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Role of the sympathetic nervous system in carbon tetrachloride-induced hepatotoxicity and systemic inflammation. [PDF]
PLoS ONE, 2015 Carbon tetrachloride (CCl4) is widely used as an animal model of hepatotoxicity and the mechanisms have been arduously studied, however, the contribution of the sympathetic nervous system (SNS) in CCl4-induced acute hepatotoxicity remains controversial ...
Jung-Chun Lin +5 more
doaj +1 more source
Studies on hepatotoxicity induced by chlorinated hydrocarbons. Lipid and ATP metabolisms in the liver of mice exposed to 1,1,2,2-tetrachloroethane [PDF]
, 1969 With a constant gas-exposure chamber newly devised, the author had Cb mice (females weighing 16.0 ± 1.5 g) inhale 600 ppm (in average) of 1, 1, 2, 2-tetrachloroethane for 3 hours.
Tomokuni, Katsumaro
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RUDN Journal of Agronomy and Animal Industries, 2013 In acute poisoning of rats with carbon tetrachloride observed polytropic xenobiotic action on the animal organism. In liver disease processes occur at the subcellular, cellular and tissue levels, blood circulation.
S M Shakirova +2 more
doaj +1 more source