Results 11 to 20 of about 2,264 (139)

Protective Effect and Mechanism of Rosiglitazone in α-amanitin-induced Hepatotoxicity Via Activation of PPAR-γ/Nrf2 Signaling Pathway. [PDF]

J Biochem Mol Toxicol
ABSTRACT α‐amanitin (α‐AMA), the primary lethal toxin of amanita, primarily targets the liver with a high toxicity and a low lethal dose. As the precise mechanism of intoxication is unclear, and specific antidotes are lacking, α‐AMA‐induced liver injury has a high mortality rate.
Lai F, Liao Y, Wu J, Wang T, Zhang G, Zhang X, Xia C, Hu J, Lu Y.   +8 more
europepmc   +2 more sources

Janus kinase 2 inhibition by pacritinib as potential therapeutic target for liver fibrosis

Hepatology, EarlyView., 2022
Diagram of the activation of the profibrotic and procontractile Janus kinase 2 (JAK2)/Ras homolog family member A/Rho‐kinase pathway and the inhibition of phosphorylated JAK2 by pacritinib to inhibit hepatic stellate cell activity. Abstract Background and Aims Janus kinase 2 (JAK2) signaling is increased in human and experimental liver fibrosis with ...
Sandra Torres, Cristina Ortiz, Nadine Bachtler, Wenyi Gu, Leon D. Grünewald, Nico Kraus, Robert Schierwagen, Christoph Hieber, Caroline Meier, Olaf Tyc, Maximilian Joseph Brol, Frank Erhard Uschner, Bart Nijmeijer, Christoph Welsch, Marie‐Luise Berres, Carmen Garcia‐Ruiz, Jose Carlos Fernandez‐Checa, Christian Trautwein, Thomas J. Vogl, Stefan Zeuzem, Jonel Trebicka, Sabine Klein   +21 more
wiley   +1 more source

A note on the stability of conjugated diene absorption of rat liver microsomal lipids after carbon tetrachloride poisoning

Journal of Lipid Research, 1971
Liver microsomal lipid peroxidation has been observed in fatal human CCl4 poisoning, in rats with fatty livers induced by CCl4 or by yellow phosphorus, and in mice poisoned with 1,1,2,2-tetrachloroethane.
S. Srinivasan, Richard O. Recknagel
doaj   +1 more source

Influence of the liposomal preparation Butaintervite on protein synthesis function in the livers of rats under the influence of carbon tetrachloride poisoning

Regulatory Mechanisms in Biosystems, 2016
This article presents the results of research into the influence of the complex liposomal preparation Butaintervit on protein synthesis function in the livers of rats under the influence of carbon tetrachloride poisoning.
M. I. Hariv, B. V. Gutyj
doaj   +1 more source

Hepatoprotectant Ursodeoxycholyl Lysophosphatidylethanolamide Increasing Phosphatidylcholine levels as a Potential Therapy of Acute Liver Injury

Frontiers in Physiology, 2012
It has been long known that hepatic synthesis of phosphatidylchoine (PC) is depressed during acute such as carbon tetrachloride-induced liver injury. Anti-hepatotoxic properties of PC as liposomes have been recognized for treatment of acute liver damage.
Walee eChamulitrat, Wujuan eZhang, Weihong eXu, Anita ePathil, Kenneth eSetchell, Wolfgang eStremmel   +5 more
doaj   +1 more source

Effects of MgCl2 supplementation on blood parameters and kidney injury of rats exposed to CCl4

Open Life Sciences, 2016
The purpose of this study was to evaluate the beneficial effects of magnesium (Mg) supplementation upon carbon tetrachloride (CCl4) toxicity. Our study was carried out on 24 Wistar male rats divided into 4 batches.
Mbarki Sakhria, Dhibi Sabah, Bouzenna Hafsia, Elfeki Abdelfettah, Hfaiedh Najla   +4 more
doaj   +1 more source

Effectiveness of enterosgel usage in the conditions of simultaneous destruction of rats by karbofos and carbon tetrachloride

Regulatory Mechanisms in Biosystems, 2014
The aim of our study was to examine the effectiveness of the enterosgel sorbent in the terms of simultaneous destruction of rats by karbofos and carbon tetrachloride.
L. А. Boyko, L. S. Fira, P. G. Lychatskiy   +2 more
doaj   +1 more source

Ozone oxidative preconditioning: a protection against cellular damage by free radicals

Mediators of Inflammation, 1998
There is some anecdotal evidence that oxygen-ozone therapy may be beneficial in some human diseases . However so far only a few biochemical and pharmacodynamic mechanisms have been elucidated.
O. S. León, S. Menéndez, N. Merino, R. Castillo, S. Sam, L. Pérez, E. Cruz, V. Bocci   +7 more
doaj   +1 more source

CX₃CR1 Mediates the Development of Monocyte-Derived Dendritic Cells during Hepatic Inflammation

Cells, 2019
Recent evidence suggests that hepatic dendritic cells (HDCs) contribute to the evolution of chronic liver diseases. However, the HDC subsets involved and the mechanisms driving these responses are still poorly understood.
Salvatore Sutti, Stefania Bruzzì, Felix Heymann, Anke Liepelt, Oliver Krenkel, Alberto Toscani, Naresh Naik Ramavath, Diego Cotella, Emanuele Albano, Frank Tacke   +9 more
doaj   +1 more source

Fungal Polysaccharides as Next‐Generation Bioactive: Advances in Structure–Activity Mapping, Mode of Action, and Biotechnological Horizons

Food Frontiers, Volume 7, Issue 3, May 2026.
ABSTRACT Fungal polysaccharides (FPs) represent a diverse class of bioactive macromolecules widely studied for their nutritional, therapeutic, and biotechnological value. This review synthesizes recent advances (2020–2025) in the structural characterization, biological functions, and translational potential of FPs.
Muhammad Aaqil, Feng Zhang, Jingchuan Zheng, Muhammad Kamil, Yuwei Guo, Cunchao Zhao, Yang Tian   +6 more
wiley   +1 more source