Results 41 to 50 of about 589,267 (308)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Genetic types and distinguished characteristics of dolomite and the origin of dolomite reservoirs

Petroleum Exploration and Development, 2018
To find out the origin of dolomite, the precipitation of primary dolomite, and the formation of pores in dolomite, petrologic and geochemical characteristics of typical samples from Sichuan and Tarim Basin were analyzed based on the previous ...
Wenzhi ZHAO, Anjiang SHEN, Zhanfeng QIAO, Liyin PAN, Anping HU, Jie ZHANG   +5 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Co‐existence of skeletal and ooid shoals as a result of antecedent topography—Cat cay shoal complex, Bahamas

The Depositional Record, 2019
High‐resolution seismic data reveal an unexpected Pleistocene topography underneath the Cat Cay shoal complex along the western margin of Great Bahama Bank, illustrating how Pleistocene topography focuses tidal flow to create different types of ...
Francisco E. G. Cruz, Gregor P. Eberli
doaj   +1 more source

Discovery of the deep-sea NEOM Brine Pools in the Gulf of Aqaba, Red Sea

Communications Earth & Environment, 2022
The sedimentary signals of climatic and tectonic events are preserved in pristine condition by the hypersaline environment within brine pools discovered by remote observations, and core and brine sampling, in the Gulf of Aqaba, off the Saudi Arabian ...
Sam J. Purkis, Hannah Shernisky, Peter K. Swart, Arash Sharifi, Amanda Oehlert, Fabio Marchese, Francesca Benzoni, Giovanni Chimienti, Gaëlle Duchâtellier, James Klaus, Gregor P. Eberli, Larry Peterson, Andrew Craig, Mattie Rodrigue, Jürgen Titschack, Graham Kolodziej, Ameer Abdulla   +16 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Study on Calcified Alkali Leaching of Vanadium-Extracted Tailings and Preparation of Barium Orthovanadate

Nanomaterials
While vanadium-extracted tailings contain valuable components, their utilization is difficult due to their high sodium content. In this work, a new oxygen-pressure calcification and alkaline leaching strategy to achieve barium orthovanadate vanadium ...
Jinwei Qu, Yiqiu Wang, Xinyu Hao, Na Ma
doaj   +1 more source

Critical Review of Solidification of Sandy Soil by Microbially Induced Carbonate Precipitation (MICP) [PDF]

, 2021
Liuxia Chen, Yuqi Song, Jicheng Huang, Chenhuan Lai, Hui Jiao, Hao Fang, Junjun Zhu, Xiangyang Song   +7 more
openalex   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source