Results 101 to 110 of about 69,223 (345)
A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms
FEBS Open Bio, EarlyView.We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley +1 more source
Renewing the Exploration Approach for Mid-Enthalpy Systems: Examples from Northern England and Scotland [PDF]
, 2015 After a promising start in the 1970s and 80s, the UK rather fell behind other countries in the search for viable mid-enthalpy geothermal resources.
Elliott, Thomas +9 more
core
FEBS Open Bio, EarlyView.The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan +6 more
wiley +1 more source
The cockroaches of the Carboniferous Epoch
Annals and Magazine of Natural History, 1889 n ...
openaire +3 more sources
Exosome Proteomics of SOD1D90A Mutation Suggest Early Disease Mechanisms, and FN1 as a Biomarker
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Amyotrophic lateral sclerosis (ALS) is a neuromuscular disease. Super oxide dismutase 1 (SOD1) gene mutations cause ALS, and the D90A mutation is associated with primarily upper motor neuron (UMN) loss. Objective Our goal is to reveal the early cellular events in ALS pathology and identify potential pharmacokinetic biomarkers, using well ...
Mukesh Gautam +6 more
wiley +1 more source
Carboniferous Fossils from Siam [PDF]
Geological Magazine, 1920 One internal cast of the pedicle-valve of a species of Athyris seems indistinguishable from A. subtilita Hall which occurs in the Carboniferous of Belgium, and has recently been recorded from Eastern Yunnan. The general shape and narrow median sulcus, the concentric sublamellose growth-ridges, and small, parallel dental plates, are well seen in our ...
openaire +3 more sources
Advanced Biology, EarlyView.The novelty of this study showed that the injection of exosomes produced from ADMSCs in combination with Roflumilast poses a more favorable therapeutic outcome for CKD induced by Adriamycin, compared to therapy with exosomes or Roflumilast alone. Roflumilast and exosomes treatment lowered the expression of the apoptotic, fibrotic, and inflammatory ...
Mohamed Ali +5 more
wiley +1 more source
The unique devonian sections of Dniepro-Donetsk cavity. Kolaidyntsy parametric well 413. Article 1
Мінеральні ресурси України, 2015 On results the boring drilling of mining hole 413 data of geophysical works were not confirmed about the depth of bedding of crystalline breeds of foundation and thickness of the Devonian sedimentations.
V. A. Ivanyshyn +4 more
doaj
About the structure of the Kama-Kinel trough system
Известия высших учебных заведений: Геология и разведка, 2019 Kama-Kinel Trough System (KKTS) — the structure formed in the Frasnian of the Late Devonian in the vast territory of the Volga-Ural province, is distinguished by the Upper Devonian — Lower Carboniferous deposits.
E. N. Gorozhanina +3 more
doaj +1 more source