Results 81 to 90 of about 29,126 (284)

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Lingulid brachiopods with probably preserved original shell colouration from the Kamensk Formation (Moscovian, Middle Pennsylvanian) of the Donets Basin, Ukraine

Вісник Харківського національного університету імені В.Н. Каразіна. Серія Геологія. Географія. Екологія
Problems Statement and Purpose. The colouration (when pigment is distributed more or less uniformly within skeletal substance) and colour patterns (when pigment is concentrated or arranged in bands, lines, spots, patches, etc.) of fossil brachiopod ...
Vitaly Dernov
doaj   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

About the structure of the Kama-Kinel trough system

Известия высших учебных заведений: Геология и разведка, 2019
Kama-Kinel Trough System (KKTS) — the structure formed in the Frasnian of the Late Devonian in the vast territory of the Volga-Ural province, is distinguished by the Upper Devonian — Lower Carboniferous deposits.
E. N. Gorozhanina, V. M. Gorozhanin, D. E. Zagranovskaya, O. A. Zakharova   +3 more
doaj   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Diagenesis and pore evolution of tight reservoirs in glutenite section of Bachu Formation, Tahe Oilfield

Shiyou shiyan dizhi
The tight reservoirs in the glutenite section of the Carboniferous Bachu Formation in the Tahe Oilfield represent an important future exploration target.
Xindong DIAO, Wenping LI, Dong JIANG, Fangfang ZHOU, Zhipeng HUO, Jianbo GAO, Ningliang SUN, Zhifeng CAO, Jianan WANG, Yanan WANG, Zhiwei CHEN, Changyu DONG   +11 more
doaj   +1 more source

Carboniferous continental margin mafic-ultramafic sheeted dyke complex in the West Magnitogorsk zone (Southern Urals)

Известия высших учебных заведений: Геология и разведка, 2019
In the West of the aHochthon of Magnitogorsk zone thrusted onto the Precambrian complexes of the Uraltau zone, the Devonian island-arc complexes overlap stratigraphicalry the Ordovician and Silurian chert-basalt sequences and serpentine melange.
A. V. Ryazantsev, L. A. Novikov, A. A. Razumovskij   +2 more
doaj   +1 more source

De novo synthesis of short‐chain aldehydes and hydrocarbons secreted by the brown marmorated stink bug Halyomorpha halys

FEBS Open Bio, EarlyView.
The brown marmorated stink bug, Halyomorpha halys, mainly secretes 4‐oxo‐(E)‐2‐hexenal, (E)‐2‐decenal, dodecane and tridecane, a mixture representative of that released by many heteropterans. We demonstrated that H. halys can synthesise these secretory components de novo using dietary glucose.
Haruna Fujimori, Koji Noge
wiley   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source