Results 71 to 80 of about 29,126 (284)
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Carboniferous-Permian Transition at Carrizo Arroyo, Central New Mexico
, 2004 Carboniferous; Permian; Carboniferous-Permian; Carrizo Arroyo; New Mexico; Central New ...
Spencer G. Lucas and Kate E. Zeigler, eds.
core
Complex examination of the Upper Paleozoic siliciclastic rocks from southern Transdanubia, SW Hungary—Mineralogical, petrographic, and geochemical study [PDF]
, 2007 A vertical section of Upper Paleozoic sandstones from southern Transdanubia (Mecsek-Villány area, Tisza mega-unit, Hungary) has been analyzed for major and trace elements, including rare earth elements (REEs).
Nesbitt +34 more
core +1 more source
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
The asbian to arnsbergian conodonts and sequence stratigraphy of the Northumberland trough [PDF]
, 2001 Yoredale sequences are excellent exemplars of the sequence stratigraphy model; the spacial and temporal variation of these complex shallow marine/fluvio-deltaic/ coastal plain cycles, exhibit all the uiternal facies architecture that would be expected of
Bowden, Alistair
core
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Carboniferous-Permian transition in Canon del Cobre, northern New Mexico
, 2010 Carboniferous; Permian; Canon del Cobre; New ...
Spencer G. Lucas, Joerg W. Schneider and Justin A. Spielmann
core
FEBS Open Bio, EarlyView.NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks +4 more
wiley +1 more source