Results 121 to 130 of about 166,028 (261)

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

open access: yesAdvanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu   +12 more
wiley   +1 more source

Nucleophilic trifluoromethylation of carbonyl compounds and derivatives

open access: yesARKIVOC, 2014
Gloria Rubiales   +3 more
doaj   +1 more source

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

open access: yesAdvanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel   +16 more
wiley   +1 more source

EDA Complex-Driven Desaturation of Heterocyclic Carbonyl Compounds Enabled by HFIP. [PDF]

open access: yesAngew Chem Int Ed Engl
Maiti R   +6 more
europepmc   +1 more source

Disorder‐Induced Extremely Low Thermal Conductivity of Graphite Fluoride

open access: yesAdvanced Science, EarlyView.
This article investigates the effect of fluorination on the thermal conductivity of graphite fluoride, demonstrating the relationship between structural modification and thermal conductivity in an extreme case. The record‐low through‐plane thermal conductivity measured in exfoliated graphite fluoride flakes was found to correlate with the wide ...
Wonsik Lee   +10 more
wiley   +1 more source

Metal‐Enhanced Charge Transport and its Mechanism in Atomically Precise Ruthenium Single‐Molecule Devices

open access: yesAdvanced Science, EarlyView.
An atomically precise platform was developed for investigating single‐molecule charge transport. This innovative platform enables the creation of highly uniform molecular devices using ruthenium‐based molecules. It reveals a significant enhancement in molecular conductance due to the metallic ruthenium center and a unique barrier‐lowering effect during
Jie Guo   +15 more
wiley   +1 more source

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