Results 211 to 220 of about 30,254 (254)
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[45] Carboxylesterases-amidases
1981Publisher Summary This chapter presents the simultaneous purification of five of the most prominent rat liver carboxylesterases-amidases. All of these enzymes are found in microsomal fraction. As a side product of the procedure described in the chapter , a dipeptidyl aminopeptidase is obtained that also belongs to the group of serine hydrolases.
Eberhard Heymann, Rolf Mentlein
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Molecular Cancer Therapeutics, 2004
Abstract Carboxylesterases, expressed at high levels in human liver and intestine, are thought to detoxify xenobiotics. The anticancer prodrug 7-ethyl-10-[4-1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) is also metabolized by carboxylesterases to produce the active drug 7-ethyl-10-hydroxycamptothecin.
Kyoung Jin P, Yoon +5 more
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Abstract Carboxylesterases, expressed at high levels in human liver and intestine, are thought to detoxify xenobiotics. The anticancer prodrug 7-ethyl-10-[4-1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) is also metabolized by carboxylesterases to produce the active drug 7-ethyl-10-hydroxycamptothecin.
Kyoung Jin P, Yoon +5 more
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Carboxylesterase from Sulfolobus solfataricus P1
2001Publisher Summary To date, relatively few investigations regarding the purification and characterization of thermostable (T opt > 60 °) esterases have been conducted. Thus far, esterases from Bacillus acidocaldarius, Pyrococcus furiosus , Bacillus stearothermophilus , Sulfolobus shibatae , Thermoanaerobacterium sp, Pyrococcus abyssi , and ...
A C, Sehgal +4 more
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2020
This chapter focuses on important issues in the design and development of prodrugs such as a different substrate specificities of human carboxylesterase isozymes and other hydrolases. Prodrugs such as acemetacin and indomethacin farnesyl have been developed to reduce the side effects of indomethacin. The prodrug enol-esterified with pivalic acid has an
Masato Takahashi, Masakiyo Hosokawa
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This chapter focuses on important issues in the design and development of prodrugs such as a different substrate specificities of human carboxylesterase isozymes and other hydrolases. Prodrugs such as acemetacin and indomethacin farnesyl have been developed to reduce the side effects of indomethacin. The prodrug enol-esterified with pivalic acid has an
Masato Takahashi, Masakiyo Hosokawa
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Canadian Journal of Biochemistry, 1975
Chicken, sheep, and horse liver carboxylesterases have been purified by procedures involving ammonium sulfate fractionation, ion-exchange chromatography and gel filtration on Sephadex. The actual yields of the procedures described were as follows: chicken, 1 g from 2 kg of liver powder (chloroform–acetone); sheep, 200 mg from 400 g of powder ...
P A, Inkerman +5 more
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Chicken, sheep, and horse liver carboxylesterases have been purified by procedures involving ammonium sulfate fractionation, ion-exchange chromatography and gel filtration on Sephadex. The actual yields of the procedures described were as follows: chicken, 1 g from 2 kg of liver powder (chloroform–acetone); sheep, 200 mg from 400 g of powder ...
P A, Inkerman +5 more
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Journal of Biochemistry, 2010
A novel gene encoding an esterase from Geobacillus thermodenitrificans strain CMB-A2 was cloned, sequenced and functionally expressed in Escherichia coli M15. Sequence analysis revealed an open reading frame of 747 bp corresponding to a polypeptide of 249 amino acid residues (named EstGtA2).
David M, Charbonneau +2 more
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A novel gene encoding an esterase from Geobacillus thermodenitrificans strain CMB-A2 was cloned, sequenced and functionally expressed in Escherichia coli M15. Sequence analysis revealed an open reading frame of 747 bp corresponding to a polypeptide of 249 amino acid residues (named EstGtA2).
David M, Charbonneau +2 more
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Pest Management Science, 2019
BACKGROUND Increased expression or point mutations of carboxyl/cholinesterases (CCEs) have been involved in many cases of insecticide and acaricide resistance.
P. Wei +6 more
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BACKGROUND Increased expression or point mutations of carboxyl/cholinesterases (CCEs) have been involved in many cases of insecticide and acaricide resistance.
P. Wei +6 more
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Biochemistry, 1969
The molecular weight of pig liver carboxylesterase (~88% pure) has been determined as 163,000 (±15,000). The enzyme has two active sites per molecular weight of 163,000 as shown by titration with pnitrophenyl dimethylcarbamate and p-nitrophenyl diethyl phosphate.
Horgan, Douglas J. +4 more
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The molecular weight of pig liver carboxylesterase (~88% pure) has been determined as 163,000 (±15,000). The enzyme has two active sites per molecular weight of 163,000 as shown by titration with pnitrophenyl dimethylcarbamate and p-nitrophenyl diethyl phosphate.
Horgan, Douglas J. +4 more
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Analytical Chemistry, 2018
Human carboxylesterase-2 (CE2) is a carboxylesterase that catalyzes the hydrolysis of endogenous and exogenous substrates. Abnormal CE2 levels are associated with various cancers, and CE2 is a key mediator of anticancer prodrugs, including irinotecan ...
S. Park +5 more
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Human carboxylesterase-2 (CE2) is a carboxylesterase that catalyzes the hydrolysis of endogenous and exogenous substrates. Abnormal CE2 levels are associated with various cancers, and CE2 is a key mediator of anticancer prodrugs, including irinotecan ...
S. Park +5 more
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Catabolism of strigolactones by a carboxylesterase
Nature Plants, 2021E. Xu +6 more
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