Results 51 to 60 of about 1,046,258 (263)

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Impact of Dispersing on the Production and Extraction of Bio-Based Basic Chemicals from Biogenic Secondary Waste

Environmental and Climate Technologies
Biogenic waste from waste treatment plants, secondary waste, can be used to produce bio-based carboxylic acids, conventionally produced by chemical synthesis from petroleum-based feedstocks or by synthesis from natural oils.
Vogt Kyra Atessa, Steinberg Iris
doaj   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Liquid-Chromatographic Methods for Carboxylic Acids in Biological Samples

Molecules, 2020
Carboxyl-bearing low-molecular-weight compounds such as keto acids, fatty acids, and other organic acids are involved in a myriad of metabolic pathways owing to their high polarity and solubility in biological fluids. Various disease areas such as cancer,
Takuya Fujiwara, Ryoto Inoue, Takuma Ohtawa, Makoto Tsunoda   +3 more
doaj   +1 more source

Photocatalytic direct borylation of carboxylic acids

Nature Communications, 2022
Boronic acids are useful reagents in organic synthesis and thus methods to prepare these compounds under mild conditions are desirable. Here, the authors synthesize boronic acids via photocatalytic decarboxylation of benzoic acids followed by borylation;
Qiang Wei, Yuhsuan Lee, Weiqiu Liang, Xiaolei Chen, Bo-shuai Mu, Xi-Yang Cui, Wangsuo Wu, Shuming Bai, Zhibo Liu   +8 more
doaj   +1 more source

De novo synthesis of short‐chain aldehydes and hydrocarbons secreted by the brown marmorated stink bug Halyomorpha halys

FEBS Open Bio, EarlyView.
The brown marmorated stink bug, Halyomorpha halys, mainly secretes 4‐oxo‐(E)‐2‐hexenal, (E)‐2‐decenal, dodecane and tridecane, a mixture representative of that released by many heteropterans. We demonstrated that H. halys can synthesise these secretory components de novo using dietary glucose.
Haruna Fujimori, Koji Noge
wiley   +1 more source

Influence of chain length and saturation on carboxylic acid pyrolysis mechanisms

Fuel Processing Technology
This study investigates radical-driven deoxygenation mechanisms during the non-catalytic pyrolysis of saturated and unsaturated carboxylic acids. Pyrolysis experiments were conducted at 410 °C, between 0.5 and 2 h, using carboxylic acids of varying ...
Bernardo A. Souto, Justice Asomaning, David C. Bressler   +2 more
doaj   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Direct deoxygenative borylation of carboxylic acids

Nature Communications, 2021
Converting a carboxylic acid into a boronic acid, which makes a useful chemical handle from a feedstock chemical, currently relies on decarboxylation and requires metal catalysts and prior functionalization.
Jianbin Li, Chia-Yu Huang, Mohamad Ataya, Rustam Z. Khaliullin, Chao-Jun Li   +4 more
doaj   +1 more source