Results 251 to 260 of about 1,109,000 (367)

Premenopausal Patients With Clinically Aggressive Metastatic Breast Cancer Successfully Treated With a First‐Line Palbociclib‐Containing Regimen: Two Cases and Literature Review

open access: yesCancer Reports, Volume 8, Issue 12, December 2025.
ABSTRACT Background Palbociclib, which is an oral small‐molecule cyclin‐dependent kinase 4 and 6 (CDK4/6) inhibitor, demonstrated its efficacy in hormone receptor‐positive (HR+) and human epidermal growth factor receptor 2‐negative (HER2−) metastatic breast cancer together with endocrine therapy.
Pei‐An Fu   +4 more
wiley   +1 more source

A Novel Carcinoembryonic Antigen T-Cell Bispecific Antibody (CEA TCB) for the Treatment of Solid Tumors

open access: yesClinical Cancer Research, 2016
M. Bacac   +27 more
semanticscholar   +1 more source

Two Cases of Epidermal Growth Factor Receptor L861R Mutation‐Positive Lung Adenocarcinoma Treated With Osimertinib and Afatinib

open access: yesCancer Reports, Volume 8, Issue 12, December 2025.
ABSTRACT Background Epidermal growth factor receptor (EGFR) mutations are detected in approximately 40%–50% of patients with lung adenocarcinoma in Asian populations and in around 10% of patients in Western populations. Among these, the EGFR L861R mutation is uncommon and undetectable using conventional polymerase chain reaction methods.
Kei Kagawa   +9 more
wiley   +1 more source

The Rare Upper Thoracic and Cervical Esophageal GIST Resected Through Thoracoscopic Esophageal Mobilization and a Cervical Approach: A Case Report

open access: yesCancer Reports, Volume 8, Issue 12, December 2025.
ABSTRACT Background Gastrointestinal stromal tumor (GIST) is the most common mesenchymal neoplasm arising from the digestive tract; however, esophageal GIST is a very rare entity and represents < 1% of all GIST cases. Furthermore, esophageal GIST is most commonly located in the lower esophagus, while esophageal GIST in the upper esophagus is rare among
Kenjiro Ishii   +13 more
wiley   +1 more source

Epigenetic dynamics in gastric cancer precancerous lesions: From molecular mechanisms to precision risk stratification

open access: yesClinical and Translational Discovery, Volume 5, Issue 6, December 2025.
Gastric precancerous lesions undergo dynamic epigenetic alterations—including DNA methylation, 5‐hydroxymethylcytosine, non‐coding RNAs, and RNA editing—throughout the Correa's cascade. The integration of these multi‐omics epigenetic signatures facilitates non‐invasive risk stratification, which guides personalised surveillance strategy and targeted ...
Kewei Ma   +4 more
wiley   +1 more source

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