Results 311 to 320 of about 84,483 (336)
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Carcinoembryonic Antigen Revisited
Annals of Internal Medicine, 1973Excerpt A recent editorial in this journal (1) reviewed the relatively brief history of carcinoembryonic (CE) antigen and indicated the increasing interest in this glycoprotein and its potential im...
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Immunoadsorbent purification of the carcinoembryonic antigen
Immunochemistry, 1977Abstract Carcinoembryonic antigen (CEA), a carbohydrate-rich glycoprotein, has been purified from human tumour tissue by three methods: (i) the procedure of Krupey et al. (1972) involving extraction with 1 M perchloric acid; (ii) by immuno-affinity chromatography using anti-CEA antibodies coupled to Sepharose 4B; and (iii) by affinity ...
Neville J. De Young, Leonie K. Ashman
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Carcinoembryonic Antigens of Erythrocyte Membranes
Nature New Biology, 1973The carcinoembryonic antigen (CEA) of Gold and Freed-man1 was first described as being specific for tumours and foetal tissue of endodermal origin. This glycoprotein, or some antigenically related counterpart, has been shown by radioimmunoassay and other procedures to occur in the urine, plasma and faeces of healthy subjects and in patients bearing a ...
A. L. Barsoum +3 more
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Antigenic Determinants of Carcinoembryonic Antigen
Scandinavian Journal of Immunology, 1978Radioimmunoassays for carcinoembryonic antigen (CEA) have been established using a variety of different antisera raised in goat, monkey, rabbit, guinea pig and rat. The extent to which different antigens compete for antibodies in the sera has been estimated.
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Specificity of the Carcinoembryonic Antigen (CEA)
New England Journal of Medicine, 1971Beginning in 1965, a series of elegant studies by Gold and his colleagues have been carried out involving the detection and characterization of a new, apparently specific, surface antigen associated with adenocarcinoma of the human colon. This particular tumor was chosen for study because of its highly localized nature; thus, both control and tumor ...
Jeffrey J. Collins, Paul H. Black
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Carcinoembryonic antigen in breast cancer
Cancer, 1978Carcinoembryonic antigen (CEA) levels were determined in 742 postoperative patients with breast cancer. Within this group the percentage of elevated (greater than or equal to 4.0 ng/ml) assays increased with UICC clinical stage and was 14.8% (12/81), 23.7% (27/114), 73.1% (190/260) and 20.0% (49/245) for stages I, II, III, IV and X (unstagable due to ...
Kellen Ja +5 more
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CARCINOEMBRYONIC ANTIGEN IN RHEUMATOID ARTHRITIS
The Lancet, 1974Abstract Carcinoembryonic antigen (C.E.A) levels measured by radioimmunoassay were significantly higher in adults with seropositive rheumatoid arthritis (18 cases) than in those without inflammatory disease (17 subjects). 10 patients with seronegative rheumatoid arthritis and 16 with ankylosing spondylitis had levels of plasma-C.E.A which did not ...
Maurice H. Lessof +2 more
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Carcinoembryonic antigen in patients with neuroblastoma
Journal of Surgical Oncology, 1974AbstractCarcinoembryonic antigen (CEA) was studied in the plasma of 17 patients (2 months to 18 years old) with neuroblastoma by means of a radioimmunoassay that detects an antigenic site in the CEA molecule at low ionic strengths. Elevated levels (greater than 2.5 nanograms per ml) of CEA were observed in plasma specimens from 8 or 9 patients with ...
L F Sinks, T M Chu, Jiping Wang
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Carcinoembryonic Antigen and Bladder Carcinoma
Journal of Urology, 1976The 24-hour urinary carcinoembryonic antigen determinations were performed on 61 patients with different stages of bladder carcinoma. Elevated titers were found in 81 per cent of the patients with active tumors and falsely positive studies were found in 7 per cent. High stage lesions were found to have high carcinoembryonic antigen levels.
Gheorghe Ionescu +6 more
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Carcinoembryonic antigen-based vaccines
Seminars in Oncology, 2003Carcinoembryonic antigen (CEA) is a glycoprotein that is normally expressed in certain parts of the body and commonly overexpressed in most carcinomas of the colon, rectum, breast, lung, pancreas, and gastrointestinal tract. Increased expression of CEA promotes increased intercellular adhesions, which may lead to metastasis. Carcinoembryonic antigen is
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