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Specificity of the Carcinoembryonic Antigen (CEA)
New England Journal of Medicine, 1971Beginning in 1965, a series of elegant studies by Gold and his colleagues have been carried out involving the detection and characterization of a new, apparently specific, surface antigen associated with adenocarcinoma of the human colon. This particular tumor was chosen for study because of its highly localized nature; thus, both control and tumor ...
Jeffrey J. Collins, Paul H. Black
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Antigenic Determinants of Carcinoembryonic Antigen
Scandinavian Journal of Immunology, 1978Radioimmunoassays for carcinoembryonic antigen (CEA) have been established using a variety of different antisera raised in goat, monkey, rabbit, guinea pig and rat. The extent to which different antigens compete for antibodies in the sera has been estimated.
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CARCINOEMBRYONIC ANTIGEN IN RHEUMATOID ARTHRITIS
The Lancet, 1974Abstract Carcinoembryonic antigen (C.E.A) levels measured by radioimmunoassay were significantly higher in adults with seropositive rheumatoid arthritis (18 cases) than in those without inflammatory disease (17 subjects). 10 patients with seronegative rheumatoid arthritis and 16 with ankylosing spondylitis had levels of plasma-C.E.A which did not ...
Maurice H. Lessof +2 more
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Carcinoembryonic antigen in patients with neuroblastoma
Journal of Surgical Oncology, 1974AbstractCarcinoembryonic antigen (CEA) was studied in the plasma of 17 patients (2 months to 18 years old) with neuroblastoma by means of a radioimmunoassay that detects an antigenic site in the CEA molecule at low ionic strengths. Elevated levels (greater than 2.5 nanograms per ml) of CEA were observed in plasma specimens from 8 or 9 patients with ...
L F Sinks, T M Chu, Jiping Wang
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Immunoadsorbent purification of the carcinoembryonic antigen
Immunochemistry, 1977Abstract Carcinoembryonic antigen (CEA), a carbohydrate-rich glycoprotein, has been purified from human tumour tissue by three methods: (i) the procedure of Krupey et al. (1972) involving extraction with 1 M perchloric acid; (ii) by immuno-affinity chromatography using anti-CEA antibodies coupled to Sepharose 4B; and (iii) by affinity ...
Neville J. De Young, Leonie K. Ashman
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Carcinoembryonic antigen in breast cancer
Cancer, 1978Carcinoembryonic antigen (CEA) levels were determined in 742 postoperative patients with breast cancer. Within this group the percentage of elevated (greater than or equal to 4.0 ng/ml) assays increased with UICC clinical stage and was 14.8% (12/81), 23.7% (27/114), 73.1% (190/260) and 20.0% (49/245) for stages I, II, III, IV and X (unstagable due to ...
Kellen Ja +5 more
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Carcinoembryonic Antigen and Bladder Carcinoma
Journal of Urology, 1976The 24-hour urinary carcinoembryonic antigen determinations were performed on 61 patients with different stages of bladder carcinoma. Elevated titers were found in 81 per cent of the patients with active tumors and falsely positive studies were found in 7 per cent. High stage lesions were found to have high carcinoembryonic antigen levels.
Gheorghe Ionescu +6 more
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Precautions in Testing for Carcinoembryonic Antigen
JAMA: The Journal of the American Medical Association, 1981To the Editor.— Certain precautions must be followed when testing for carcinoembryonic antigen (CEA) in patients with cancer. Tests for CEA are to be used only for treatment of cancer patients and assessing prognosis. They are not intended for screening or diagnosis.
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Carcinoembryonic antigen. Clinical application
Cancer, 1976Carcinoembryionic antigen (CEA) a glycoprotein extracted from colonic cancer tissue (beta-globulin electrophoretic mobility, sedimentation coefficient 7 to 8S, and mol wt approximately 200,000) can be detected and measured by radioimmunoassay. Clinical evaluations of CEA determination have given the following results: In health: (1) Serum CEA level is ...
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