Results 111 to 120 of about 172,865 (359)

Supplementary Fig 8 from Ubiquitin Ligases Siah1a/2 Control Alveolar Macrophage Functions to Limit Carcinogen-Induced Lung Adenocarcinoma [PDF]

, 2023
Marzia Scortegagna, Yuanning Du, Linda M. Bradley, Kun Wang, Alfredo Molinolo, Eytan Ruppin, Rabi Murad, Ze’ev A. Ronai   +7 more
openalex   +1 more source

Affinity‐Based Protein Profiling Revealed that HIGD1A is a Direct Target Protein of Aristolochic Acids

Advanced Science, EarlyView.
Using an affinity‐based probe, this study reveals that aristolochic acid directly binds to HIGD1A with high affinity in the kidney. This binding disrupts the HIGD1A‐TFAM interaction, which in turn triggers TFAM degradation, cytosolic mitochondrial DNA release, and the activation of inflammatory pathways. Abstract Exposure to aristolochic acids (AA) via
Yin Gong, Shanshan Zhang, Anying Wei, Xiang Ji, Xiaodan Chong, Jinfeng Cen, Xuan Zhao, Zimeng Luo, Zhipeng Pei, Guanchao Mao, Xinkang Zhang, Mingxue Sun, Zhiguo Sun, Zifei Yin, Zhengrong Zou, Wen‐Qi Meng   +15 more
wiley   +1 more source

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source

Two-faced Janus: on the 150^th anniversary of the discovery of DDT

Успехи молекулярной онкологии
One of the factors associated with increased morbidity of malignant neoplasms is environmental pollution with cancerogenic compounds including pesticides.
O. V. Morozova, A. Yu. Bukina, V. G. Popova, G. I. Khairieva, G. R. Sagitova, G. A. Belitsky, M. G. Yakubovskaya, K. I. Kirsanov, V. P. Maksimova   +8 more
doaj   +1 more source

Molecular biomarkers and toxic consequences of impact by organic pollution in aquatic organisms [PDF]

, 1994
Organic contaminants are readily bioaccumulated by aquatic organisms. Exposure to and toxic effects of contaminants can be measured in terms of the biochemical responses of the organisms (i.e. molecular biomarkers).
Förlin, L., George, S.G., Livingston, D.R.   +2 more
core  

Systematic review of the scientific evidence on ethylene oxide as a human carcinogen

, 2022
Heather N. Lynch, Jordan S. Kozal, Anthony J. Russell, William J. Thompson, Haley R. Divis, Rachel D. Freid, Edward J. Calabrese, Kenneth A. Mundt   +7 more
openalex   +1 more source

Arid1a Deficiency Drives Aristolochic Acid‐Induced Liver Tumorigenesis through Ctnnb1 Mutation and Defective Nucleotide Excision Repair

Advanced Science, EarlyView.
ARID1A is frequently mutated in both non‐malignant tissues and cancers, but its role in tumor development after exposure to genotoxic carcinogen remains unclear. It is found that aristolochic acid I accelerated liver tumorigenesis in ARID1A‐deficient context by impairing nucleotide excision repair and enhancing carcinogen bioactivation, revealing key ...
Lan Wang, Shi‐Hao Bai, Shu‐Jin Song, Xiao‐Li Zhang, Xue‐Ying Shang, Zhao‐Ning Lu, Xiao‐Fang Cui, Xin‐Le Zhu, Ze‐Guang Han   +8 more
wiley   +1 more source

Review on mechanisms and therapeutic advances in inorganic arsenic-induced reproductive system disorders

All Life
Inorganic arsenic (iAs), a toxic metalloid and recognized carcinogen, is widely distributed in the natural environment. Human exposure to iAs occurs via multiple pathways, leading to its accumulation and adverse effects on the human body.
Chengke Lu, Xinyu Li, Xin Zhao, Zhiyuan Zou, JiaXin Zhao, Jia Liu, Ying Zhao, Wei Zou   +7 more
doaj   +1 more source

Anti-IGF-1R monoclonal antibody inhibits the carcinogenicity activity of acquired trastuzumab-resistant SKOV3 [PDF]

, 2014
Wei Wang, Yan Zhang, Ming Lv, Jiannan Feng, Hui Peng, Jing Geng, Lin Zhou, Tingting Zhou, Xinying Li, Bing Shen, Yuanfang Ma, Chunxia Qiao   +11 more
openalex   +1 more source

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source