Results 211 to 220 of about 173,309 (360)

Is Indoor Air Pollution the Missing Link Between Radon and Lung Cancer? Rethinking Epidemiological Support for the LNT Model. [PDF]

Dose Response
Lee DH.
europepmc   +1 more source

Persistent and carcinogenic polycyclic aromatic hydrocarbons in the north-western coastal marine environment of India

, 2021
Pravin U. Singare, J. P. Shirodkar
openalex   +2 more sources

Sustainability in Analytical Chemistry Illustrated by Pharmaceutical Nitrosamine Testing

ELECTROPHORESIS, EarlyView.
ABSTRACT Following the valsartan scandal in 2018, the testing of drug substances and drug products for N‐nitrosamines has become a critical and mandatory quality control measure. The European Pharmacopoeia chapter 2.5.42 currently describes three analytical methods for this purpose: HPLC–MS/MS, GC–MS, and GC–MS/MS.
Felix Bredendiek, Sebastian Schmidtsdorff, Maria Kristina Parr   +2 more
wiley   +1 more source

Carcinogenicity studies

Folia Pharmacologica Japonica, 2007
openaire   +3 more sources

Rivers of Tears - Convergent, Multi-Scale Approaches to Monitor and Optimize the Health of Our World's Inhabitants. [PDF]

Glob Chall
Anderson EJ, Sansalone V, Lee LP, Grainger R, Lee S, Juhasz AL, Knothe Tate ML.   +6 more
europepmc   +1 more source

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal, Guangchao Chen, Kerry L. Dearfield, Min Gi, Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Alexandra S. Long, David P. Lovell, Barbara L. Parsons, Stefan Pfuhler, John Wills, Andreas Zeller, George Johnson, Paul A. White   +14 more
wiley   +1 more source

SIRT3-IDH2 axis is a target of dietary fructose: implication of IDH2 as a key player in dietary carcinogen toxicity in mice colon. [PDF]

Exp Mol Med
Pan JH, Aykin-Burns N, Krager KJ, Shin HR, Lee CH, Lee JH, Kong B, Myoung J, Choi KC, Kim JK.   +9 more
europepmc   +1 more source

Comparison of chronic toxicity and carcinogenicity of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD) in 2‐year bioassays in female Sprague‐Dawley rats

, 2006
Nigel J. Walker, Michael E. Wyde, Lawrence J. Fischer, Abraham Nyska, John R. Bucher   +4 more
openalex   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Cancer Chemo-Preventive Potential of Calligonum polygonoides Stem Extract Against DMBA Induced Skin Carcinogenesis. [PDF]

Asian Pac J Cancer Prev
Meghwal GP, Jeengar MK, Jangeer S, Sharma KK, Patel DD, Meena P.   +5 more
europepmc   +1 more source