Results 221 to 230 of about 170,355 (359)

Health impacts and risk assessment of PM_2.5 and PM₁₀ at Suburban Site in Pathum Thani, Thailand. [PDF]

Toxicol Rep
Rattanaphra D, Tawkaew S, Kingkam W, Nuchdang S, Kitpakornsanti K, Suwanmanee U.   +5 more
europepmc   +1 more source

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal, Guangchao Chen, Kerry L. Dearfield, Min Gi, Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Alexandra S. Long, David P. Lovell, Barbara L. Parsons, Stefan Pfuhler, John Wills, Andreas Zeller, George Johnson, Paul A. White   +14 more
wiley   +1 more source

Past Marks: A Case Report of Basal Cell Carcinoma Induced by Arsenic Exposure. [PDF]

Cureus
Carreira P, Coutinho M, Lopez S, Constantino R, Almeida S.   +4 more
europepmc   +1 more source

NICOTINE AND SOME CARCINOGENS IN SPECIAL REFERENCE TO THE HEPATIC DRUG-METABOLIZING ENZYMES

, 1966
Iwao Yamamoto, Kazuo Nagai, Hiroshi Kimura, Katsuya Iwatsubo   +3 more
openalex   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Nrf2 Hyperactivation as a Driver of Radiotherapy Resistance and Suppressed Antitumor Immunity in Head and Neck Squamous Cell Carcinoma. [PDF]

Clin Cancer Res
Patel R, Saab K, Luo L, Ma Y, Osman RA, Williams NT, Everitt J, Zelazowski MJ, Castro P, Decker WK, Hudson WH, Myers JN, Sandulache VC, Frederick MJ, Mowery YM, Kirsch DG.   +15 more
europepmc   +1 more source

Carcinogenic Effect of Prolonged Exposure to Grenz Ray11From the Departments of Dermatology and Pathology, Baylor University College of Medicine, Houston, Texas.Supported in part by Contract No. DA-49-007-MD-953, Medical Research and Development Command, Department of the Army, Office of The Surgeon General.Presented at the Twenty-second Annual Meeting of the Society for Investigative Dermatology, Inc., New York, N.Y., June 29, 1961.

, 1961
Edward M. Shapiro, John M. Knox, Robert G. Freeman   +2 more
openalex   +1 more source

A Carcinogenic Action of Testosterone, provoking Uterine Tumours in Mice [PDF]

, 1961
R. Van Nie, E. L. Benedetti, O. Mühlbock   +2 more
openalex   +1 more source

Epigenotoxicity: Decoding the epigenetic imprints of genotoxic agents and their implications for regulatory genetic toxicology

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk, Christopher Faulk, Jessica LaRocca, Jan van Benthem, Francesco Marchetti   +4 more
wiley   +1 more source

Brassica Extracts Prevent Benzo(a)pyrene-Induced Transformation by Modulating Reactive Oxygen Species and Autophagy. [PDF]

Int J Mol Sci
Montes-Alvarado JB, Garcia-Ibañez P, Moreno DA, Sarmiento-Salinas FL, Susano-Hernández XE, Larrauri-Rodríguez KA, García-Hernández FJ, Milflores-Flores L, Domínguez F, Maycotte P.   +9 more
europepmc   +1 more source