Results 231 to 240 of about 172,865 (359)

Air Pollutants in Puerto Rico: Key Pollutants and Carcinogenic Properties. [PDF]

Int J Environ Res Public Health
Kaya D, Santiago C, Pernas E, Truong S, Martinez G, Méndez LB, Delgado Y.   +6 more
europepmc   +1 more source

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal, Guangchao Chen, Kerry L. Dearfield, Min Gi, Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Alexandra S. Long, David P. Lovell, Barbara L. Parsons, Stefan Pfuhler, John Wills, Andreas Zeller, George Johnson, Paul A. White   +14 more
wiley   +1 more source

Health impacts and risk assessment of PM_2.5 and PM₁₀ at Suburban Site in Pathum Thani, Thailand. [PDF]

Toxicol Rep
Rattanaphra D, Tawkaew S, Kingkam W, Nuchdang S, Kitpakornsanti K, Suwanmanee U.   +5 more
europepmc   +1 more source

The Alabama DDT Settlement Fund [PDF]

, 1990
McGovern, Francis E.
core   +3 more sources

Cigarette Smoking as a Carcinogenic Risk Factor in Cancer of the Larynx and Pharynx

, 2005
Hiroshi Miyahara
openalex   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Mechanistic interplay between aflatoxin B1 and tissue inhibitor of metalloproteinase-3 in hepatocellular carcinoma. [PDF]

World J Hepatol
Luo Y, Wang LJ, Wang CL.
europepmc   +1 more source

Epigenotoxicity: Decoding the epigenetic imprints of genotoxic agents and their implications for regulatory genetic toxicology

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk, Christopher Faulk, Jessica LaRocca, Jan van Benthem, Francesco Marchetti   +4 more
wiley   +1 more source

A novel carcinogenic mouse model by site-directed insertion of tandem human HRAS large DNA fragment into 15E1 site. [PDF]

Animal Model Exp Med
Liu S, Yang Y, Huo G, Yang Zhao H, Ling C, Wang Y, Zhai S, Sun X, Gu W, Cao Y, Gong W, Wang S, Fan C.   +12 more
europepmc   +1 more source

PharmaceuticalNitrosamines: A Comprehensive Reviewof Health Risks, Detection, Mitigation Strategies Supplemented withCYP450 Interactions as Molecular Simulations for Mechanistic Insightinto Carcinogenicity

Kardile Punam Kashinath (21787467), Md Samim Sardar (21787470), Subhadeep Roy (1274595), Anoop Kumar (44), Santanu Kaity (1755532)   +4 more
openalex   +1 more source