Results 241 to 250 of about 172,865 (359)

Evaluation of the standard battery of in vitro genotoxicity tests to predict in vivo genotoxicity through mathematical modeling: A report from the 8th International Workshop on Genotoxicity Testing

Environmental and Molecular Mutagenesis, EarlyView.
Abstract In human health risk assessment of chemicals and pharmaceuticals, identification of genotoxicity hazard usually starts with a standard battery of in vitro genotoxicity tests, which is needed to cover all genotoxicity endpoints. The individual tests included in the battery are not designed to pick up all endpoints.
Mirjam Luijten, Jan van Benthem, Takeshi Morita, Raffaella Corvi, Patricia A. Escobar, Yurika Fujita, Jennifer Hemmerich, Naveed Honarvar, David Kirkland, Naoki Koyama, David P. Lovell, Miriam Mathea, Andrew Williams, Stephen Dertinger, Stefan Pfuhler, Jeroen L. A. Pennings   +15 more
wiley   +1 more source

Microbial Therapeutics in Cancer: Translating Probiotics, Prebiotics, Synbiotics, and Postbiotics From Mechanistic Insights to Clinical Applications: A Topical Review. [PDF]

FASEB J
Tegegne BA, Abebaw D, Teffera ZH, Fenta A, Belew H, Belayneh M, Jemal M, Getinet M, Baylie T, Tamene FB, Belay WY, Wondim SA, Zeleke TK.   +12 more
europepmc   +1 more source

Consensus findings of an International Workshops on Genotoxicity Testing workshop on using transcriptomic biomarkers to predict genotoxicity

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Gene expression biomarkers have the potential to identify genotoxic and non‐genotoxic carcinogens, providing opportunities for integrated testing and reducing animal use. In August 2022, an International Workshops on Genotoxicity Testing (IWGT) workshop was held to critically review current methods to identify genotoxicants using ...
Roland Froetschl, J. Christopher Corton, Henghong Li, Jiri Aubrecht, Scott S. Auerbach, Florian Caiment, Tatyana Y. Doktorova, Yurika Fujita, Danyel Jennen, Naoki Koyama, Matthew J. Meier, Roman Mezencev, Leslie Recio, Takayoshi Suzuki, Carole L. Yauk   +14 more
wiley   +1 more source

Development of Korean CARcinogen EXposure: IARC Group 2A Carcinogens. [PDF]

Saf Health Work
Koh DH, Choi S, Park JH, Lee SG, Kim HC, Kim I, Min J, Kim Y, Lee J, Park DU.   +9 more
europepmc   +1 more source

Effects of chemical carcinogens on fish liver histology /

, 1986
William K. Parland
openalex   +1 more source

Review of Transcriptomic Biomarkers That Predict In Vitro Genotoxicity in Human Cell Lines

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT The current genotoxicity testing paradigm provides little mechanistic information, has poor specificity in predicting carcinogenicity in humans, and is not suited to assessing a large number of chemicals. Genomic technologies enable the characterization of genome‐wide transcriptional changes in response to chemical treatments that can inform ...
Heng‐Hong Li, Jiri Aubrecht, Tatyana Y. Doktorova, Danyel Jennen, J. Christopher Corton, Roland Froetschl, Roman Mezencev, Carole L. Yauk   +7 more
wiley   +1 more source

Past Marks: A Case Report of Basal Cell Carcinoma Induced by Arsenic Exposure. [PDF]

Cureus
Carreira P, Coutinho M, Lopez S, Constantino R, Almeida S.   +4 more
europepmc   +1 more source

Sustainable polypropylene chair: A life cycle assessment and cost analysis of industrial production

Environmental Progress &Sustainable Energy, EarlyView.
Abstract Due to their multiple properties, including flexibility, lightness, and strength, thermoplastics are an essential material in the development of processes at both industrial and domestic levels. However, thermoplastics are often derived from polymers synthesized using non‐renewable petroleum resources. This has environmental consequences.
Lucrezia Maggi, Alberto Pietro Damiano Baltrocchi, Marco Carnevale Miino, Elena Cristina Rada, Vincenzo Torretta   +4 more
wiley   +1 more source

Nrf2 Hyperactivation as a Driver of Radiotherapy Resistance and Suppressed Antitumor Immunity in Head and Neck Squamous Cell Carcinoma. [PDF]

Clin Cancer Res
Patel R, Saab K, Luo L, Ma Y, Osman RA, Williams NT, Everitt J, Zelazowski MJ, Castro P, Decker WK, Hudson WH, Myers JN, Sandulache VC, Frederick MJ, Mowery YM, Kirsch DG.   +15 more
europepmc   +1 more source

Detection of Cell Carcinogenic Transformation by a Quadruplex DNA Binding Fluorescent Probe

, 2014
Tsung‐Lin Yang, Lin Lin, Pei‐Jen Lou, Ta‐Chau Chang, Tai‐Horng Young   +4 more
openalex   +2 more sources