Results 271 to 280 of about 167,587 (340)

Consensus findings of an International Workshops on Genotoxicity Testing workshop on using transcriptomic biomarkers to predict genotoxicity

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Gene expression biomarkers have the potential to identify genotoxic and non‐genotoxic carcinogens, providing opportunities for integrated testing and reducing animal use. In August 2022, an International Workshops on Genotoxicity Testing (IWGT) workshop was held to critically review current methods to identify genotoxicants using ...
Roland Froetschl, J. Christopher Corton, Henghong Li, Jiri Aubrecht, Scott S. Auerbach, Florian Caiment, Tatyana Y. Doktorova, Yurika Fujita, Danyel Jennen, Naoki Koyama, Matthew J. Meier, Roman Mezencev, Leslie Recio, Takayoshi Suzuki, Carole L. Yauk   +14 more
wiley   +1 more source

Increased mutagenicity in the liver of MutaMouse females following oral treatment with commercial-grade toluene diisocyanate. [PDF]

Genes Environ
Matsumoto M, Natsume M, Iso T, Umano T, Murata Y, Masumura K, Horibata K, Sugiyama KI.   +7 more
europepmc   +1 more source

Carcinogenic action of cigarette smoke condensate on mouse skin.

, 1967
T. D. Day
openalex   +1 more source

Food Quality Protection Act of 1996: Science and Law at a Crossroads [PDF]

, 1997
Miller, Andrew J.
core   +1 more source

Review of Transcriptomic Biomarkers That Predict In Vitro Genotoxicity in Human Cell Lines

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT The current genotoxicity testing paradigm provides little mechanistic information, has poor specificity in predicting carcinogenicity in humans, and is not suited to assessing a large number of chemicals. Genomic technologies enable the characterization of genome‐wide transcriptional changes in response to chemical treatments that can inform ...
Heng‐Hong Li, Jiri Aubrecht, Tatyana Y. Doktorova, Danyel Jennen, J. Christopher Corton, Roland Froetschl, Roman Mezencev, Carole L. Yauk   +7 more
wiley   +1 more source

Cutting-Edge Advancements in the Antibiotics-Gut Microbiota-Urinary Tumour Axis. [PDF]

Cell Prolif
Wang J, Li D, Wu R, Feng D.
europepmc   +1 more source

Antigenicity of carcinogen-induced and spontaneous tumours in inbred mice.

, 1966
Hans‐Jørgen Smith
openalex   +1 more source

The Humble Almond: Why Congress Should Institute the Precautionary Principle to Guide Regulation of Environmental Toxins and Food Additives [PDF]

, 2015
Nauheim, David Alan
core   +1 more source

Transferability, Reproducibility and Sensitivity of Mutation Quantification by Duplex Sequencing

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT Duplex Sequencing (DS) is an ultra‐accurate, error‐corrected next generation sequencing (ecNGS) technology for mutation analysis. A working group (WG) within Health and Environmental Sciences Institute's Genetic Toxicology Technical Committee is investigating the suitability of ecNGS for regulatory mutagenicity testing, using DS as a model ...
Shaofei Zhang, Barbara L. Parsons, Devon Fitzgerald, Anne Ashford, James Todd Auman, Tao Chen, Annette Dodge, Azeddine Elhajouji, Lena Pfaller, Shawn Harris, Jake Higgins, Cheryl A. Hobbs, Francesco Marchetti, Matthew J. Meier, Meagan B. Myers, Jesse Salk, Rebecca Sahroui, David Schuster, Raja Settivari, Stephanie L. Smith‐Roe, Carole L. Yauk, Jian Yan, Andrew Williams, Connie L. Chen   +23 more
wiley   +1 more source

On the Stoichiometric Interactions between 4-Nitroquinoline 1-Oxide and Deoxyribonucleosides, with Special Reference to the Mode of Binding of the Carcinogen to DNA

, 1967
TEISUKE OKANO, Kaneto Uekama
openalex   +2 more sources