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Chemico-Biological Interactions, 2021
Current regulatory cancer risk assessment principles and practices assume a linear dose-response relationship-the linear no-threshold (LNT) model-that theoretically estimates cancer risks occurring following low doses of carcinogens by linearly extrapolating downward from experimentally determined risks at high doses.
Nicholas D. Priest +2 more
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Current regulatory cancer risk assessment principles and practices assume a linear dose-response relationship-the linear no-threshold (LNT) model-that theoretically estimates cancer risks occurring following low doses of carcinogens by linearly extrapolating downward from experimentally determined risks at high doses.
Nicholas D. Priest +2 more
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Carcinogens and Anticarcinogens
1986There is the potential for major progress in the prevention of cancer in the next 5 or 10 years. In the short term, progress in the prevention of cancer depends on a better understanding of some of the risk factors and antirisk factors for the major human cancers.
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Mutagens, Carcinogens, and Anti-Carcinogens
1982Mutagens and carcinogens in the environment represent a potential hazard, and it is important to screen large numbers of compounds and mixtures of compounds to which humans are exposed. However, it is Impractical for both technical and monetary reasons to do the bulk of mutagen screening by using mammals.
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Reviews on Environmental Health, 1979
The study of bracken carcinogenicity affords an interesting example of the close alliance, with mutual benefit, between the work of veterinarians in the field and experimental research. On the one hand was the condition found in many parts of the world of bovine enzootic haematuria with uncertain aetiology and, on the other, the investigations ...
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The study of bracken carcinogenicity affords an interesting example of the close alliance, with mutual benefit, between the work of veterinarians in the field and experimental research. On the one hand was the condition found in many parts of the world of bovine enzootic haematuria with uncertain aetiology and, on the other, the investigations ...
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Carcinogenicity and Modification of Carcinogenic Response by Antioxidants
1990Synthetic or naturally occurring antioxidants such as butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), propyl gallate sodium L-ascorbate, and α-tocopherol have been widely used as food additives in various processed foods to prevent auto-oxidation of fatty acids.
Masao Hirose +3 more
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Nature, 1962
IT has been shown previously that cobalt metal powder suspended in fowl serum and injected intramuscularly into rats is a potent and rapid carcinogen. This metal produces mainly rhabdomyosarcomata1–3. Zinc and tungsten metal powders injected in the same way produce no tumours.
J. T. Dingle +3 more
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IT has been shown previously that cobalt metal powder suspended in fowl serum and injected intramuscularly into rats is a potent and rapid carcinogen. This metal produces mainly rhabdomyosarcomata1–3. Zinc and tungsten metal powders injected in the same way produce no tumours.
J. T. Dingle +3 more
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Environmental Research, 1979
Abstract Lindane is highly carcinogenic in rats and mice. Lindane induced benign and malignant neoplasms at all sites in male and female rats. Benign and malignant neoplasms of the endocrine organs were also increased. Carcinomas of the adrenal and pituitary were increased markedly in male and female rats.
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Abstract Lindane is highly carcinogenic in rats and mice. Lindane induced benign and malignant neoplasms at all sites in male and female rats. Benign and malignant neoplasms of the endocrine organs were also increased. Carcinomas of the adrenal and pituitary were increased markedly in male and female rats.
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Proceedings of the Royal Society of London. Series B - Biological Sciences, 1957
In confirmation of previous reports from this Institute, cholesterol has been shown to be carcinogenic. Highly purified cholesterol (Schwenk process), dissolved in olive oil by heating on the water-bath, was injected subcutaneously into 224 stock mice. Fourteen sarcomas were induced at the site of injection.
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In confirmation of previous reports from this Institute, cholesterol has been shown to be carcinogenic. Highly purified cholesterol (Schwenk process), dissolved in olive oil by heating on the water-bath, was injected subcutaneously into 224 stock mice. Fourteen sarcomas were induced at the site of injection.
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Nature, 1954 THE effects of various metals on living cells in tissue culture are being investigated in this Laboratory, and a non-lethal disturbance of normal mitosis produced in chick fibroblasts by cobalt (as chloride) has already been reported1. This effect, which is characterized by the persistence of the nucleoli in mitotic cells throughout prophase into meta-,
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Archives of Dermatology, 1968
To the Editor.— In regard to the question of the proven carcinogenicity of arsenic in animal studies, raised in the article on "Syndactilism, Dyschromia, and the Arsenical Dilemma," in theArchives 98 :107 (Aug) 1968 by Cornelius and Shelley, it should be noted that this has been documented by W. Knoth ( Arch Klin Exp Derm 227 :228, 1966).
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To the Editor.— In regard to the question of the proven carcinogenicity of arsenic in animal studies, raised in the article on "Syndactilism, Dyschromia, and the Arsenical Dilemma," in theArchives 98 :107 (Aug) 1968 by Cornelius and Shelley, it should be noted that this has been documented by W. Knoth ( Arch Klin Exp Derm 227 :228, 1966).
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