Results 171 to 180 of about 650,641 (407)
Advanced Science, EarlyView.Inducing ferroptosis is a promising strategy for combating tumor resistance. Upregulated PIP5K1A competes with NRF2 for KEAP1 binding, which decreases the ubiquitination degradation of NRF2 and promotes its nuclear translocation, thereby suppressing ferroptosis, and ultimately driving hepatocellular carcinoma (HCC) tumorigeneses and sorafenib ...
Mengzhou Guo +9 more
wiley +1 more source
The Cancer SENESCopedia: A delineation of cancer cell senescence
Cell Reports, 2021 Summary: Cellular senescence is characterized as a stable proliferation arrest that can be triggered by multiple stresses. Most knowledge about senescent cells is obtained from studies in primary cells.
Fleur Jochems +13 more
doaj
Insulin Injections Promote the Growth of Aberrant Crypt Foci in the Colon of Rats [PDF]
, 1997 The main objective of the present study was to test the hypothesis that exogenous insulin would enhance colon carcinogenesis. Thirty-six female F344 rats, fed ad libitum a low fat rodent chow, received a single azoxymethane injection (20 mg/kg), and were
Corpet, Denis E. +3 more
core +1 more source
, 2015 Mechanistic multi-stage models are used to analyze lung-cancer mortality after Plutonium exposure in the Mayak-workers cohort, with follow-up until 2008.
Eidemüller, Markus +2 more
core +2 more sources
Double Mass Extinctions and the Volcanogenic Dark Matter Scenario [PDF]
arXiv, 1998 A few of the major mass extinctions of paleontology have recently been found to consist of two distinct extinction peaks at higher resolution. A viable explanation for this remains elusive. In this paper it is shown that the recently proposed volcanogenic dark matter model can explain this puzzling characteristic of these extinctions.
arxiv
EGFR‐TKIs Induced DPP4 Drives Metabolic Reprogramming of Persister Cells in Lung Cancer
Advanced Science, EarlyView.Drug‐tolerant persister (DTP) cells emerge early during EGFR‐TKI treatment, preceding the development of acquired resistance. Elevated DPP4 in DTP cells drives metabolic reprogramming and antioxidant adaptation, promoting cell survival under drug pressure.
Yuanzhou Zhang +7 more
wiley +1 more source
Environment InternationalExposure to environmental carcinogens is a significant contributor to cancer development, with genetic and epigenetic alterations playing pivotal roles in the carcinogenic process.
Yufei Liu +12 more
doaj
Molecular mechanisms of nickel carcinogenesis: nickel binding to histone H4 and Cap43 protein [PDF]
, 2005 The carcinogenicity of nickel compounds has been confirmed and corroborated by numerous epidemiological studies in humans and carcinogenesis bioassays in animals.
Medici, Serenella +2 more
core
AGING MEDICINE, EarlyView.This study employed Mendelian Randomization to assess 1,400 blood metabolites and found a significant inverse association between the glycine‐to‐serine ratio and prostate cancer risk, suggesting a potential causal relationship. ABSTRACT Objectives Metabolic dysregulation is common in cancer, yet evidence linking circulating metabolites to causal ...
Xiaojin Lu +8 more
wiley +1 more source