Results 161 to 170 of about 281,280 (268)

High‐Sugar Diet and Intestinal Diseases: A Shared Microbiota–Barrier–Immunity–Metabolism Axis in Inflammatory Bowel Disease, Food Allergy, and Colorectal Cancer

iNew Medicine, EarlyView.
ABSTRACT The global incidence of intestinal diseases—including food allergy, inflammatory bowel disease (IBD), and colorectal cancer (CRC)—continues to escalate in parallel with the expansion of the “Western diet,” within which the high‐sugar diet (HSD) has emerged as a pivotal yet under‐recognized dietary driver.
Yuchen Wang, Yajuan Wu, Huayang Sheng, Shouhong Jiang, Jinping Cheng, Ye Kuang, Miao Liu, Lei Feng, Yanan Sun, Jinzhi Duan   +9 more
wiley   +1 more source

Hepatic Sinusoidal Obstruction Syndrome Induced by Pyrrolizidine Alkaloids: Mechanistic Insights, Emerging Biomarkers, and Therapeutic Innovations

iNew Medicine, EarlyView.
ABSTRACT Hepatic sinusoidal obstruction syndrome (HSOS) is a microcirculatory disorder of the liver that poses a serious threat to human health. Pyrrolizidine alkaloids (PAs), a class of toxins widely found in plants, are often ingested accidentally and are one of the major causes of HSOS.
Fumin Zhang, Cheng Zhu, Xingyu Li, Yaoling Zhu, Domingo Antonio Sánchez Martínez, Ying Dai, Lifeng Guo, Derun Kong   +7 more
wiley   +1 more source

The emerging role of CRISPR-Cas systems in helicobacter pylori and the gut microbiota as regulators of gastrointestinal cancer risk. [PDF]

Front Immunol
Bhatti M, Thalib HI, Tayyebah A, Zobairi A, Dahan N, Hassan FE.   +5 more
europepmc   +1 more source

CSRP1 Drives Helicobacter pylori‐Associated Gastric Cancer Progression via IL‐6/JAK2/STAT3‐Mediated Epithelial–Mesenchymal Transition

iNew Medicine, EarlyView.
Helicobacter pylori infection‐associated chronic gastritis induces CSRP1 upregulation in gastric cancer cells. Elevated CSRP1 activates the IL‐6/JAK2/STAT3 signaling pathway by promoting IL‐6 expression, JAK2 phosphorylation, and STAT3 nuclear translocation.
Chao Li, Wanjing Chen, Yawei He, Yida Lu, Gang Yu, Ruqiong Wei, Raquel Alarcón Rodríguez, Zhengguang Wang   +7 more
wiley   +1 more source

The STAT1 lexicon: translating signaling codes in <i>H. pylori</i>-driven gastric carcinogenesis. [PDF]

Front Immunol
Han W, He H, Ye B, Sun Y, Wang X, Liu T, Cui H, Wang J.   +7 more
europepmc   +1 more source

A Comprehensive Study to Compare Different Compound Representations for Predicting Carcinogenicity In Vivo

Journal of Applied Toxicology, EarlyView.
ABSTRACT Carcinogenicity evaluation is a critical component of chemical risk assessment, yet traditional in vivo testing remains time consuming, costly, and ethically challenging. Computational approaches based on machine learning offer promising alternatives, but the relative contributions of different molecular representation strategies for ...
Iuri Barbosa Pereira, Rogerio Salvini, Eloisa Dutra Caldas   +2 more
wiley   +1 more source

Dual Genotoxic and Antigenotoxic Effects of 3‐Benzoylcoumarins in Mammalian Cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Coumarins are phenolic compounds widely recognized for their diverse pharmacological activities and have attracted increasing attention as potential chemopreventive agents. In the present study, four known 3‐benzoylcoumarin derivatives [(1), (2), (3), and (4)] were evaluated for their cytotoxic, mutagenic, and antigenotoxic effects in Chinese ...
Leticia Helena Parreira, Evelyn Pinheiro de Mendonça, Aléxia Polo Siqueira, Cleydson Finotti Cordeiro, Elkin José Torres Sierra, Rudy Bonfilio, Diogo Teixeira Carvalho, Pollyanna Francielli de Oliveira   +7 more
wiley   +1 more source

Cytotoxic and Genotoxic Effects in Buccal Cells of Sandstone Quarry Workers

Journal of Applied Toxicology, EarlyView.
ABSTRACT Mineral extraction poses significant occupational health risks, particularly from respirable crystalline silica exposure. Sandstone quarrying generates substantial dust, yet evidence of its genotoxic effects remains limited. This study investigated cytogenotoxic damage in sandstone quarry workers from southern Brazil using the buccal ...
Ana Carolina de Quadros Duarte, Maria Isabela Toniazzo, Rayne Vallada da Luz, Cleisson Guimarães Bueno, Daniela Müller de Quevedo, Luciano Basso da Silva, Daiane Bolzan Berlese   +6 more
wiley   +1 more source

[Carcinogenesis of IPMN].

Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 2012
TADA, Minoru, KOIKE, Kazuhiko
openaire   +2 more sources

The Oral Microbiome in Oral Cavity Cancer: Mechanisms of Carcinogenesis, Biomarkers, and Therapeutic Implications. [PDF]

Curr Oncol Rep
Pazdro-Zastawny K, Kos M, Leszczyszyn A, Zawadzki T, Pietruszka K, Dorobisz K.   +5 more
europepmc   +1 more source