Results 141 to 150 of about 327,951 (318)

The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome

Biological Reviews, EarlyView.
ABSTRACT The gut tissue is at the frontline of early onset of ageing. It exhibits high cell turnover rates and rapid telomere shortening, which can have systemic effects on the developing or senescing organism. We conducted a literature review of studies on the crosstalk between telomere length dynamics, telomerase activity, oxidative stress, and gut ...
Michael L. Pepke, Søren B. Hansen, Morten T. Limborg   +2 more
wiley   +1 more source

Tumour suppressors in liver carcinogenesis.

, 2007
The circuitous cell signalling pathways of hepatocytes comprise several factors that operate to downgrade or even interrupt the transmission of a given signal. These down-regulating influences are essential to keep cell proliferation and cell survival in
Toftgård, Rune, Dufour, JF, Huber, O, Dufour, Jean-François, Kozma, SC, Lu, Xin, Dufour, J-F, Kozma, Sara C, Toftgård, R, Huber, Otmar, Lu, X   +10 more
core   +1 more source

From Inflammatory Bowel Disease to Cancer: Gut Microbiota–Immune Microenvironment Crosstalk and Natural Product‐Based Therapeutic Opportunities

Cancer Nexus, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD), primarily Crohn's disease and ulcerative colitis, is a chronic relapsing inflammatory disorder of the gastrointestinal tract and an important risk factor for IBD‐associated cancer. Increasing evidence suggests that gut microbiota dysbiosis, epithelial barrier dysfunction, and immune microenvironment remodeling
Xue Zhang, Chongchong Gao, Rui Jiang, Zijian Wu, Jian Bai   +4 more
wiley   +1 more source

Carcinogenesis trajectories

Frontiers in Cell and Developmental Biology
Introduction Cancer origin patterns significantly influence cancer phenotypes and hallmark characteristics. Method In the present review, four distinct carcinogenesis trajectories that contribute to malignant transformation: mutator ...
Wang, Rui, Yan, Zhaopeng
openaire   +2 more sources

Genome Libraries

, 2014
Cancer Origins and Carcinogenesis The asymmetric division of a cancer stem cell produces a replacement stem cell ...
Immunoprecipitation Kit, Carcinogenesis, Imprint Chromatin   +2 more
core  

Sex hormone-induced mammary carcinogenesis in female Noble rats: The role of androgens

, 1999
Breast cancer is the most common cancer and the second most frequent cause of cancer death in women. Despite extensive research, the precise mechanisms of breast carcinogenesis remain unclear.
Wong, YC, Tsao, SW, Xie, B
core   +1 more source

Machine Learning–Enhanced Fluorescence Cryptography with NADH‐Responsive Polymer Dots

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
This study presents a smart anticounterfeiting system using semiconducting polymer dots (Pdots) that exhibit tunable fluorescence responses to NADH. By integrating these dynamic optical signals with machine learning–based decoding, the work establishes a secure and intelligent encryption platform, showing a novel strategy that links chemical sensing ...
Zhengkun Zhan, Mingyue Gong, Zirui Zeng, Hangyu Liu, Xiaoliang Li, Zhuxin Dong, Xiaoju Men, Haobin Chen   +7 more
wiley   +1 more source

ZIP: a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis

, 2009
Despite the importance of epidermal growth factor receptor (EGFR) in animal development and malignant transformation, surprisingly little is known about the regulation of its expression.
Li, Ruifang, Yu, Wenhua, Zhang, Yu, Zhang, Hua, Chen, Yupeng, Gui, Bin, Wang, Yan, Yang, Xiaohan, Li, Yanyan, Shang, Yongfeng, Liang, Jing, Sun, Luyang, Shi, Lei   +12 more
core   +1 more source

Comparing Transcriptomic Responses to Chemicals Across Six Species Using the EcoToxChip RNASeq Database

Environmental Toxicology and Chemistry, EarlyView.
Abstract The EcoToxChip project includes RNA‐sequencing data from experiments involving model (Japanese quail, fathead minnow, African clawed frog) and ecological (double‐crested cormorant, rainbow trout, northern leopard frog) species at multiple life stages (whole embryo and adult) exposed to eight chemicals of environmental concern known to perturb ...
Krittika Mittal, Jessica Ewald, Doug Crump, Jessica Head, Markus Hecker, Natacha Hogan, Jianguo Xia, Niladri Basu   +7 more
wiley   +1 more source

Role of growth hormone in the regulation of the c-myc gene during progression of sex-differentiated rat liver carcinogenesis in the resistant hepatocyte model

, 1991
In this study, we extended the previous observations of a growth hormone-regulated sex difference in hepatic c-myc expression in the resistant hepatocyte model during the selection/promotion phase, when sex differences in growth rate of enzyme-altered ...
Gustafsson, JA, Hällström, IP, Blanck, A   +2 more
core   +1 more source