Results 251 to 260 of about 534,637 (340)

Outcome of IWGT workshop on transcriptomic biomarkers for genotoxicity: Key considerations for bioinformatics

Environmental and Molecular Mutagenesis, EarlyView.
Abstract As a part of the International Workshop on Genotoxicity Testing (IWGT) in 2022, a workgroup was formed to evaluate the level of validation and regulatory acceptance of transcriptomic biomarkers that identify genotoxic substances. Several such biomarkers have been developed using various molecular techniques and computational approaches. Within
Matthew J. Meier, Florian Caiment, J. Christopher Corton, Roland Frötschl, Yurika Fujita, Danyel Jennen, Roman Mezencev, Carole Yauk   +7 more
wiley   +1 more source

RETRACTION: MYH10 Combines with MYH9 to Recruit USP45 by Deubiquitinating Snail and Promotes Serous Ovarian Cancer Carcinogenesis, Progression, and Cisplatin Resistance. [PDF]

Adv Sci (Weinh)
europepmc   +1 more source

From dysbiosis to precision therapy: decoding the gut-bladder axis in bladder carcinogenesis. [PDF]

Front Oncol
Liu ZQ, Yang XY, Chen JH, Ge SC, Dai SX, Zhu SH, Xian ZY.   +6 more
europepmc   +1 more source

Experimental Carcinogenesis and the Problem of Food Additives

, 1960
Robert E. Eckardt
openalex   +1 more source

Microdosimetry and its implication for the Primary Processes in radiation carcinogenesis [PDF]

, 1976
Kellerer, Albrecht M., Yuhas, John M.
core  

Critical Evaluation of Methods for the Identification of Aneugens

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT The genotoxic potential of chemicals must be evaluated in regulatory safety assessment settings, including but not limited to, the development of new pharmaceuticals, industrial chemicals, food and cosmetic ingredients, and agrochemicals. Initial assessment of the chromosome‐damaging potential of chemicals is often conducted in mammalian cells
Xiaowen Sun, Stephen D. Dertinger, Azeddine Elhajouji, Daniel J. Roberts, Jan van Benthem, Maik Schuler, Shambhu Roy, Alexandra Taraboletti, Connie L. Chen   +8 more
wiley   +1 more source

The two “hit” and multiple “hit” theories of carcinogenesis.

, 1969
David J. B. Ashley
openalex   +2 more sources

Identifying Gene Predictors of Chemicals Linked With Breast Cancer: A Machine Learning Analysis of MCF7 Cellular Transcriptomic Screening Data

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT Breast cancer is the most prevalent cancer in women and has been linked to exposure to environmental chemicals. However, many chemicals have not been evaluated for relationships with this outcome. In this study, we analyzed RNA sequencing data from human breast cancer‐derived MCF7 cells exposed to hundreds of individual chemicals.
Lauren E. Koval, Richard Judson, Julia E. Rager   +2 more
wiley   +1 more source

MECHANISM OF VIRAL CARCINOGENESIS BY DNA MAMMALIAN VIRUSES, II. VIRAL-SPECIFIC RNA IN TUMOR CELLS INDUCED BY “WEAKLY” ONCOGENIC HUMAN ADENOVIRUSES

, 1967
Kei Fujinaga, Maurice Green
openalex   +1 more source

Comparing Transcriptomic Responses to Chemicals Across Six Species Using the EcoToxChip RNASeq Database

Environmental Toxicology and Chemistry, EarlyView.
Abstract The EcoToxChip project includes RNA‐sequencing data from experiments involving model (Japanese quail, fathead minnow, African clawed frog) and ecological (double‐crested cormorant, rainbow trout, northern leopard frog) species at multiple life stages (whole embryo and adult) exposed to eight chemicals of environmental concern known to perturb ...
Krittika Mittal, Jessica Ewald, Doug Crump, Jessica Head, Markus Hecker, Natacha Hogan, Jianguo Xia, Niladri Basu   +7 more
wiley   +1 more source