Results 271 to 280 of about 542,674 (361)

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

Interdisciplinary Medicine, EarlyView.
SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu, Zichang Chen, Yinting Hu, Gokhan Zengin, Qian Zhang, Meng‐Yao Li, Wenlong Sun   +6 more
wiley   +1 more source

Molecular mechanisms of inhalable iron-containing particles driving lung carcinogenesis through the <i>LCN2</i> signaling axis revealed by transcriptomic analysis. [PDF]

Transl Cancer Res
Wang L, Jiang B, He R, Zhao X, Wang D, Lv Y, Zhao G, Shao X, Li G.   +8 more
europepmc   +1 more source

No Promoting Effect of Ethyl <i>Tertiary</i>-butyl Ether (ETBE)on Rat Urinary Bladder Carcinogenesis Initiated with <i>N</i>-Butyl-<i>N</i>-(4-hydroxybutyl)nitrosamine

, 2013
Akihiro Hagiwara, Norio Imai, Yuko Doi, Mayuko Suguro, Mayumi Kawabe, Fumio Furukawa, Kasuke Nagano, Shoji Fukushima   +7 more
openalex   +2 more sources

Immunomodulation of the Prostate Tumor Microenvironment Following Inorganic Arsenic Exposure

Journal of Applied Toxicology, EarlyView.
ABSTRACT The tumor microenvironment (TME) influences prostate cancer (PCa) progression through stromal and immune interactions. Adipose‐derived mesenchymal stromal cells (ASCs) modulate immune tone, while inorganic arsenic (iAs), a widespread toxicant, is linked to immune suppression and carcinogenesis.
Joseph J. Shearer, Cosette Rivera‐Cruz, Alexandre M. B. Cavalca, Carlos Eduardo Fonseca‐Alves, Marxa L. Figueiredo   +4 more
wiley   +1 more source

Myosteatosis mediates the link between specific dietary components and colorectal carcinogenesis: from PPLSS multi-center study. [PDF]

Asia Pac J Clin Nutr
Li CW, Hsieh Y, Li C, Zhang Y, Jiang LJ, Yu SL, Dong LC, Tan ZQ, Zhang J, Xu J, Kang Y.   +10 more
europepmc   +1 more source

Beyond Tradition: An Integrated Toxicological, Ecological, and Public Health Perspective on Aristolochic Acids

Journal of Applied Toxicology, EarlyView.
ABSTRACT Aristolochia species have long been used in traditional medicine for their presumed anti‐inflammatory, analgesic and antimicrobial properties. However, extensive toxicological and epidemiological evidence now demonstrates that these plants contain aristolochic acids (AAs) I and II, highly potent nephrotoxic, genotoxic, and carcinogenic ...
Victor Ventura de Souza, Lara Rodrigues De Andrade, Tatiana da Silva Souza   +2 more
wiley   +1 more source

Correction: Isolation, culture, and in vitro functional validation of intratumor bacteria from lung cancer patients. [PDF]

BMC Microbiol
Sun Y, Tong J, Tan Y, Liu Y, Li D, Yu H, He Y, Li J, Jia B, Xiong H, Chi Y, Yang R, Wang Z, Bi Y.   +13 more
europepmc   +1 more source

Bisphenol A Induces DNA Damage and Differential Cytotoxicity in Thyroid Cells: High‐Dose Effects Challenge Regulatory Thresholds

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA), a ubiquitous environmental endocrine disruptor, has been implicated in carcinogenesis; however, its effects on thyroid cells remain unclear. This study investigated BPA‐induced cytotoxicity and genotoxicity in thyroid cell lines, including normal follicular (Nthy‐ori 3‐1), papillary carcinoma (TPC‐1 and BCPAP) and anaplastic
Izabela Fernanda Dal' Bó, Natássia Elena Bufalo, Valdemar Máximo, Laura Sterian Ward   +3 more
wiley   +1 more source

Prognostic Value and Therapeutic Potential of Novel Markers and Pathways in Oral Squamous Cell Carcinoma. [PDF]

Biomedicines
Devaraja K, Aggarwal S.
europepmc   +1 more source

Evaluation of DNA/Chromosome Integrity and Cell Death in Human Metabolically Noncompetent and Competent Cells Exposed to N′‐(3,5‐Difluorobenzylidene)Pyridine‐4‐Carbohydrazide

Journal of Applied Toxicology, EarlyView.
ABSTRACT The N‐acylhydrazone scaffold is recognized as a privileged structure for the design of bioactive substances with increasing applications in medicinal chemistry research. Ensuring the safety of newly developed molecules is a critical step for both human health and environmental protection. Accordingly, this study aimed to evaluate the cytotoxic
Larissa Ribeiro Canuto Santos, Jéssica Natalia Barbosa de Almeida, Camila Cavalleiro Frias, Wanda Pereira Almeida, Edson Luis Maistro   +4 more
wiley   +1 more source