Results 331 to 340 of about 650,641 (407)

Enhancer‐dependent gene regulation in space, time, and malignancies

International Journal of Cancer, EarlyView.
Abstract Control of cell‐type‐specific gene activation requires the coordinated activity of distal regulatory elements, including enhancers, whose inputs must be temporally integrated. Dysregulation of this regulatory capacity, such as aberrant usage of enhancers, can result in malignant transformation of cells.
Belinda Blum, Victoria Dachtler, Angelika Feldmann   +2 more
wiley   +1 more source

Sestrins in Carcinogenesis-The Firefighters That Sometimes Stoke the Fire. [PDF]

Cancers (Basel)
Haidurov A, Budanov AV.
europepmc   +1 more source

Food Quality Protection Act of 1996: Science and Law at a Crossroads [PDF]

, 1997
Miller, Andrew J.
core   +1 more source

Whole‐genome sequencing of 1,083 HPV45 cases and controls identifies genetic variants associated with glandular cervical lesions

International Journal of Cancer, EarlyView.
What's New? Little is known about how genetic variation in human papillomavirus type 45 (HPV45) influences its ability to cause cancer. Here, the authors conducted the largest whole‐genome sequencing study to date of HPV45, looking for associations between viral genetic variation and precancer or cancer risk.
Aimee J. Koestler, Chase W. Nelson, Meredith Yeager, Zigui Chen, Sambit K. Mishra, Laurie Burdett, Michael Dean, Elizabeth Suh‐Burgmann, Thomas Lorey, Gary M. Clifford, Nicolas Wentzensen, Philip E. Castle, Mark Schiffman, Robert D. Burk, Lisa Mirabello   +14 more
wiley   +1 more source

Comprehensive analysis of scRNA-seq and bulk RNA-seq data via machine learning and bioinformatics reveals the role of lysine metabolism-related genes in gastric carcinogenesis. [PDF]

BMC Cancer
Shao Y, Chen C, Yu X, Yan J, Guo J, Ye G.   +5 more
europepmc   +1 more source

Association between prediagnostic serum metabolites and pancreatic ductal adenocarcinoma risk in two prospective cohorts

International Journal of Cancer, EarlyView.
What's New? Exposures and mechanisms that contribute to and promote pancreatic ductal adenocarcinoma (PDAC) remain unclear. In this study, the authors applied metabolomics to better understand PDAC etiology by examining associations between prediagnostic serum metabolites and PDAC risk.
Ting Zhang, Steven C. Moore, Sheng Fu, Xiaoyu Wang, Demetrius Albanes, Stephanie J. Weinstein, Kai Yu, Rachael Z. Stolzenberg‐Solomon   +7 more
wiley   +1 more source

Mitochondrial Complex I Molecular Alterations in Sapajus apella as a Human Gastric Carcinogenesis Model After MNU Exposure. [PDF]

J Med Primatol
Dias BDS, Antunes SR, Pinheiro DDR, Burbano RMR, Borges BDN.   +4 more
europepmc   +1 more source

Associations of sarcopenia, sarcopenia components and sarcopenic obesity with cancer incidence: A prospective cohort study of 414,094 participants in UK Biobank

International Journal of Cancer, EarlyView.
What's New? Sarcopenia is highly prevalent and associated with adverse outcomes in cancer survivors. However, evidence regarding the role of sarcopenia in the general population as a potential risk factor for cancer development is scarce. This prospective cohort study investigated the association of sarcopenia with the incidence of 19 cancers in a ...
Panagiotis Filis, Christos K. Papagiannopoulos, Georgios Markozannes, Christos V. Chalitsios, Ioannis Zerdes, Antonios Valachis, Christopher Papandreou, Sofia Christakoudi, Konstantinos K. Tsilidis   +8 more
wiley   +1 more source

HPV-Negative Oral Squamous Cell Carcinoma Arising from Oral Submucous Fibrosis with p16INK4A Positivity and Cellular Senescence: A Case Report. [PDF]

J Clin Exp Dent
Chaurasia A, Pantelis P, Theocharous G, Veroutis D, Kotsinas A, Gorgouli EV, Georgakopoulou E.   +6 more
europepmc   +1 more source

The potential role of environmentally associated DNA methylation in childhood acute lymphoblastic leukaemia subtypes

International Journal of Cancer, EarlyView.
What's New? The rarity of acute lymphoblastic leukaemia and lack of available environmental data have made the role of environmental factors in genetic subtypes challenging to investigate. Here, the authors performed a CpG‐level analysis to investigate DNA methylation as an intermediate mechanism between environmental risk exposures and acute ...
Jessica R. Saville, Lisa J. Russell, Kay Padget, Akram Ghantous, Jessica Nordlund, Jill A. McKay   +5 more
wiley   +1 more source