Results 361 to 370 of about 650,641 (407)
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Critical Reviews in Oncology/Hematology, 2002
Metal ions play an important role in biological systems, and without their catalytic presence in trace or ultratrace amounts many essential co-factors for many biochemical reactions would not take place. However, they become toxic to cells when their concentrations surpass certain optimal (natural) levels. Copper is an essential metal. Catalytic copper,
J. Anastassopoulou, T. Theophanides
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Metal ions play an important role in biological systems, and without their catalytic presence in trace or ultratrace amounts many essential co-factors for many biochemical reactions would not take place. However, they become toxic to cells when their concentrations surpass certain optimal (natural) levels. Copper is an essential metal. Catalytic copper,
J. Anastassopoulou, T. Theophanides
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Seminars in Oncology Nursing, 1992
The rationale for identifying carcinogens and their mechanisms of action is twofold. First, carcinogens must be identified so they can be eliminated from our environment. And second, mechanisms must be identified that are involved in the conversion of a normal cell to a cancer cell. This knowledge will offer more approaches to cancer prevention.
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The rationale for identifying carcinogens and their mechanisms of action is twofold. First, carcinogens must be identified so they can be eliminated from our environment. And second, mechanisms must be identified that are involved in the conversion of a normal cell to a cancer cell. This knowledge will offer more approaches to cancer prevention.
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Cancer Letters, 2012
SUMOylation is a post-translational modification characterized by covalent and reversible binding of small ubiquitin-like modifier (SUMO) to a target protein. In mammals, four different isoforms, termed SUMO-1, -2, -3 and -4 have been identified so far.
Bettermann +4 more
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SUMOylation is a post-translational modification characterized by covalent and reversible binding of small ubiquitin-like modifier (SUMO) to a target protein. In mammals, four different isoforms, termed SUMO-1, -2, -3 and -4 have been identified so far.
Bettermann +4 more
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Cancer, 1975
The field of chemical carcinogenesis is reviewed, with emphasis on three aspects: 1) environmental chemicals are a major cause of human cancer; 2) most chemical carcinogens require metabolic activation by mixed-function oxidases to electrophilic metabolites that form strong covalent chemical bonds with cellular macromolecules and thereby initiate the ...
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The field of chemical carcinogenesis is reviewed, with emphasis on three aspects: 1) environmental chemicals are a major cause of human cancer; 2) most chemical carcinogens require metabolic activation by mixed-function oxidases to electrophilic metabolites that form strong covalent chemical bonds with cellular macromolecules and thereby initiate the ...
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Langenbeck's Archives of Surgery, 2011 In most patients, gastric cancer is diagnosed in advanced stage. Curative treatment options are limited and the mortality is high. The process of gastric carcinogenesis is triggered by Helicobacter pylori-driven gastritis and is further characterized by its complexity of interaction with other risk factors.
Jan Bornschein, Peter Malfertheiner
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Estrogen carcinogenesis in breast cancer.
New England Journal of Medicine, 2006n this article, we review recent findings related to estrogen exposure and the risk of breast cancer, the mechanisms that may be involved, and the clinical implications of these findings.
J. Yager, N. Davidson
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Journal of Steroid Biochemistry, 1975
Abstract The unopposed continuous administration of biologically active estrogenic materials produces a wide variety of cancers in experimental animals. Most of these cancers occur in the target tissues for estrogenic activity and appear to be characteristic of the animal rather than the estrogens.
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Abstract The unopposed continuous administration of biologically active estrogenic materials produces a wide variety of cancers in experimental animals. Most of these cancers occur in the target tissues for estrogenic activity and appear to be characteristic of the animal rather than the estrogens.
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Folia Pharmacologica Japonica, 2002
Multiple forms of cytochrome P450 play important roles in metabolic activation of a variety of environmental procarcinogens. Large species differences in substrate specificities between experimental animals and humans are critical factors in evaluation of chemical safety.
Hiroshi Yamazaki, Tetsuya Kamataki
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Multiple forms of cytochrome P450 play important roles in metabolic activation of a variety of environmental procarcinogens. Large species differences in substrate specificities between experimental animals and humans are critical factors in evaluation of chemical safety.
Hiroshi Yamazaki, Tetsuya Kamataki
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Mediterranean Journal of Nutrition and Metabolism, 2009
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Testino, G., Borro, P.
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Testino, G., Borro, P.
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Regulatory Toxicology and Pharmacology, 1995
For decades, it has been known that a number of different factors (e.g., species, metabolism, age, animal husbandry, diet) may exhibit a significant modulating effect on the process of carcinogenesis. Often, however, these modulators have been largely uncontrolled and thus have made uncertain the results of many carcinogenicity bioassays.
Earle R. Nestmann +3 more
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For decades, it has been known that a number of different factors (e.g., species, metabolism, age, animal husbandry, diet) may exhibit a significant modulating effect on the process of carcinogenesis. Often, however, these modulators have been largely uncontrolled and thus have made uncertain the results of many carcinogenicity bioassays.
Earle R. Nestmann +3 more
openaire +3 more sources